1. Notch Signaling in Pancreatic Development
- Author
-
Xuyan Li, Chun-Bo Teng, and Wenjun Zhai
- Subjects
medicine.medical_specialty ,Cell signaling ,Notch signaling pathway ,Review ,Biology ,Fibroblast growth factor ,Catalysis ,maintenance ,Inorganic Chemistry ,lcsh:Chemistry ,Internal medicine ,medicine ,Animals ,Humans ,Physical and Theoretical Chemistry ,Pancreas ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Tissue homeostasis ,Notch signaling ,Receptors, Notch ,Organic Chemistry ,Wnt signaling pathway ,General Medicine ,differentiation ,Computer Science Applications ,Cell biology ,Fibroblast Growth Factors ,Endocrinology ,Notch proteins ,lcsh:Biology (General) ,lcsh:QD1-999 ,Hes3 signaling axis ,pancreatic progenitor ,Cyclin-dependent kinase 8 ,Signal Transduction - Abstract
The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.
- Published
- 2015