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Your search keyword '"Shoko Sato"' showing total 2 results
Start Over Author "Shoko Sato" Journal international journal of molecular sciences
2 results on '"Shoko Sato"'

1. Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells

Author

Puspo E. Giriwono, Hitoshi Shirakawa, Yusuke Ohsaki, Shoko Sato, Yukihide Aoyama, Hsin-Jung Ho, Tomoko Goto, and Michio Komai

Subjects
anti-inflammation, geranylgeraniol, IRAK1, isoprenoid, TRAF6, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NFκB signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NFκB activation that can lead to numerous diseases.

Published
2019
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2. Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells

Author

Shoko Sato, Tomoko Goto, Michio Komai, Yusuke Ohsaki, Yukihide Aoyama, Hsin Jung Ho, Hitoshi Shirakawa, and Puspo Edi Giriwono

Subjects
Lipopolysaccharides, Cell signaling, Lipopolysaccharide, THP-1 Cells, IRAK1, Models, Biological, Catalysis, Article, Cell Line, lcsh:Chemistry, Inorganic Chemistry, chemistry.chemical_compound, Mice, Geranylgeraniol, Macrophage, Animals, Humans, RNA, Messenger, Physical and Theoretical Chemistry, Phosphorylation, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Inflammation, TNF Receptor-Associated Factor 6, Innate immune system, isoprenoid, Chemistry, Kinase, organic chemicals, Macrophages, Organic Chemistry, NF-kappa B, General Medicine, geranylgeraniol, anti-inflammation, Computer Science Applications, Cell biology, Interleukin-1 Receptor-Associated Kinases, RAW 264.7 Cells, lcsh:Biology (General), lcsh:QD1-999, lipids (amino acids, peptides, and proteins), Tumor necrosis factor alpha, Diterpenes, TRAF6, Signal Transduction
Abstract

Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NF&kappa, B). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NF&kappa, B signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NF&kappa, B activation that can lead to numerous diseases.

Published
2019

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