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Your search keyword '"Sandrini, Leonardo"' showing total 9 results
Start Over Author "Sandrini, Leonardo" Journal international journal of molecular sciences
9 results on '"Sandrini, Leonardo"'

2. Plasma Exosome Profile in ST-Elevation Myocardial Infarction Patients with and without Out-of-Hospital Cardiac Arrest

Author

Zarà, Marta, primary, Campodonico, Jeness, additional, Cosentino, Nicola, additional, Biondi, Maria Luisa, additional, Amadio, Patrizia, additional, Milanesi, Gloria, additional, Assanelli, Emilio, additional, Cerri, Silvia, additional, Biggiogera, Marco, additional, Sandrini, Leonardo, additional, Tedesco, Calogero Claudio, additional, Veglia, Fabrizio, additional, Trabattoni, Daniela, additional, Blandini, Fabio, additional, Tremoli, Elena, additional, Marenzi, Giancarlo, additional, and Barbieri, Silvia S., additional

Published
2021
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8. Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis

Author

Silvia S. Barbieri, Elena Tremoli, Leonardo Sandrini, Patrizia Amadio, Alessandro Di Minno, Alessandro Ieraci, Sandrini, Leonardo, Di Minno, Alessandro, Amadio, Patrizia, Ieraci, Alessandro, Tremoli, Elena, and Barbieri, Silvia S.

Subjects
0301 basic medicine, Oncology, Male, medicine.medical_specialty, obesity, Databases, Factual, Review, Catalysis, Catalysi, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Neurotrophic factors, Internal medicine, Medicine, Animals, Humans, Meta-analysi, Physical and Theoretical Chemistry, Receptor, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Brain-derived neurotrophic factor, business.industry, Animal, Brain-Derived Neurotrophic Factor, Organic Chemistry, Brain, Computer Science Applications1707 Computer Vision and Pattern Recognition, General Medicine, medicine.disease, Obesity, Computer Science Applications, Bdnf gene, meta-analysis, 030104 developmental biology, BDNF, lcsh:Biology (General), lcsh:QD1-999, Meta-analysis, Female, business, 030217 neurology & neurosurgery, Systematic search, Human
Abstract

Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: −0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: −0.93 ng/mL, 95% CI: −3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: −0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions.

Published
2018

9. Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNF Val/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis.

Author

Sandrini L, Ieraci A, Amadio P, Veglia F, Popoli M, Lee FS, Tremoli E, and Barbieri SS

Subjects
Animals, Aorta metabolism, Aorta pathology, Bone Marrow Cells cytology, Coronary Thrombosis etiology, Coronary Thrombosis pathology, Male, Mice, Mutation, Missense, Platelet Aggregation, Brain-Derived Neurotrophic Factor genetics, Coronary Thrombosis genetics, Gene-Environment Interaction, Stress, Psychological complications
Abstract

Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD). Interestingly, stressful conditions unveil the anxious/depressive-like behavioral phenotype in heterozygous BDNFVal66Met (BDNF Val/Met ) mice, suggesting an important relationship in terms of gene-environment interaction (GxE). However, the interplay between stress and BDNF Val/Met in relation to CVD is completely unknown. Here, we showed that BDNF Val/Met mice display a greater propensity to arterial thrombosis than wild type BDNF Val/Val mice after 7 days of restraint stress (RS). RS markedly increased the number of leukocytes and platelets, and induced hyper-responsive platelets as showed by increased circulating platelet/leukocyte aggregates and enhanced expression of P-selectin and GPIIbIIIa in heterozygous mutant mice. In addition, stressed BDNF Val/Met mice had a greater number of large and reticulated platelets but comparable number and maturation profile of bone marrow megakaryocytes compared to BDNF Val/Val mice. Interestingly, RS led to a significant reduction of BDNF expression accompanied by an increased activity of tissue factor in the aorta of both BDNF Val/Val and BDNF Val/Met mice. In conclusion, we provide evidence that sub-chronic stress unveils prothrombotic phenotype in heterozygous BDNF Val66Met mice affecting both the number and functionality of blood circulating cells, and the expression of key thrombotic molecules in aorta. Human studies will be crucial to understand whether this GxE interaction need to be taken into account in risk stratification of coronary artery disease (CAD) patients.

Published
2018
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