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Your search keyword '"Rochira, Alessio"' showing total 5 results
Start Over Author "Rochira, Alessio" Journal international journal of molecular sciences
5 results on '"Rochira, Alessio"'

1. Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

Author

Palermo, Andrea, primary, Giannotti, Laura, additional, Di Chiara Stanca, Benedetta, additional, Ferrante, Franco, additional, Gnoni, Antonio, additional, Nitti, Paola, additional, Calabriso, Nadia, additional, Demitri, Christian, additional, Damiano, Fabrizio, additional, Batani, Tiziano, additional, Lungherini, Massimo, additional, Carluccio, Maria Annunziata, additional, Rapone, Biagio, additional, Qorri, Erda, additional, Scarano, Antonio, additional, Siculella, Luisa, additional, Stanca, Eleonora, additional, and Rochira, Alessio, additional

Published
2022
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2. Analysis of CGF Biomolecules, Structure and Cell Population: Characterization of the Stemness Features of CGF Cells and Osteogenic Potential

Author

Stanca, Eleonora, primary, Calabriso, Nadia, additional, Giannotti, Laura, additional, Nitti, Paola, additional, Damiano, Fabrizio, additional, Stanca, Benedetta Di Chiara, additional, Carluccio, Maria Annunziata, additional, De Benedetto, Giuseppe Egidio, additional, Demitri, Christian, additional, Palermo, Andrea, additional, Ferrante, Franco, additional, Siculella, Luisa, additional, and Rochira, Alessio, additional

Published
2021
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5. Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms

Author

Alessio Rochira, Antonio Gnoni, Luisa Siculella, Fabrizio Damiano, Damiano, Fabrizio, Rochira, Alessio, Gnoni, Antonio, and Siculella, Luisa

Subjects
0301 basic medicine, Diiodothyronines, Catabolite repression, Review, 3,5,3′-triiodo-l-thyronine, lcsh:Chemistry, chemistry.chemical_compound, Gene expression, lcsh:QH301-705.5, Spectroscopy, fatty acid synthase, Fatty Acids, General Medicine, Computer Science Applications, Mitochondria, acetyl-CoA carboxylase, Biochemistry, Liver, Lipogenesis, Triiodothyronine, medicine.medical_specialty, Cell signaling, citrate carrier, Biology, Models, Biological, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Fatty acid synthesis, de novo lipogenesi, Fatty acid metabolism, Organic Chemistry, Lipid Metabolism, Metabolic pathway, Thyroxine, 030104 developmental biology, Endocrinology, de novo lipogenesis, chemistry, lcsh:Biology (General), lcsh:QD1-999, Basal metabolic rate, lipid lowering action, 3,5-diiodo-l-thyronine
Abstract

The thyroid hormones (THs) 3,3′,5,5′-tetraiodo-l-thyronine (T4) and 3,5,3′-triiodo-l-thyronine (T3) influence many metabolic pathways. The major physiological function of THs is to sustain basal energy expenditure, by acting primarily on carbohydrate and lipid catabolism. Beyond the mobilization and degradation of lipids, at the hepatic level THs stimulate the de novo fatty acid synthesis (de novo lipogenesis, DNL), through both the modulation of gene expression and the rapid activation of cell signalling pathways. 3,5-Diiodo-l-thyronine (T2), previously considered only a T3 catabolite, has been shown to mimic some of T3 effects on lipid catabolism. However, T2 action is more rapid than that of T3, and seems to be independent of protein synthesis. An inhibitory effect on DNL has been documented for T2. Here, we give an overview of the mechanisms of THs action on liver fatty acid metabolism, focusing on the different effects exerted by T2 and T3 on the regulation of the DNL. The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer.

Published
2017

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