Search

Your search keyword '"Luize G. Lima"' showing total 2 results
Start Over Author "Luize G. Lima" Journal international journal of molecular sciences
2 results on '"Luize G. Lima"'

1. Twist1 Influences the Expression of Leading Members of the IL-17 Signaling Pathway in HER2-Positive Breast Cancer Cells

Author

Bruno R. B. Pires, Renata Binato, Gerson M. Ferreira, Stephany Corrêa, Bárbara Du Rocher, Daniel Bulzico, Susanne Crocamo, Everton Cruz dos Santos, Luize G. Lima, and Eliana Abdelhay

Subjects
breast cancer, HER2, Twist1, IL17, gene expression, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Breast cancer (BC) is a heterogeneous disease composed of multiple subtypes with different molecular characteristics and clinical outcomes. The metastatic process in BC depends on the transcription factors (TFs) related to epithelial-mesenchymal transition (EMT), including the master regulator Twist1. However, its role beyond EMT in BC subtypes remains unclear. Our study aimed to investigate the role of Twist1, beyond EMT, in the molecular subtypes of BC. In patients, we observed the overexpression of TWIST1 in the HER2+ group. The silencing of TWIST1 in HER2+ BC cells resulted in the upregulation of 138 genes and the downregulation of 174 genes compared to control cells in a microarray assay. In silico analysis revealed correlations between Twist1 and important biological processes such as the Th17-mediated immune response, suggesting that Twist1 could be relevant for IL-17 signaling in HER2+ BC. IL-17 signaling was then examined, and it was shown that TWIST1 knockdown caused the downregulation of leading members of IL-17 signaling pathway. Taken together, our findings suggest that Twist1 plays a role on IL-17 signaling in HER2+ BC.

Published
2021
Full Text
View/download PDF

2. Twist1 Influences the Expression of Leading Members of the IL-17 Signaling Pathway in HER2-Positive Breast Cancer Cells

Author

Bárbara Du Rocher, Eliana Abdelhay, Daniel Bulzico, Stephany Corrêa, Everton Cruz dos Santos, Luize G. Lima, Susanne Crocamo, Bruno R. B. Pires, Gerson M. Ferreira, and Renata Binato

Subjects
animal structures, Microarray, QH301-705.5, Receptor, ErbB-2, Breast Neoplasms, Biology, Catalysis, Article, Inorganic Chemistry, Immune system, breast cancer, Downregulation and upregulation, Cell Line, Tumor, HER2, Gene expression, Gene silencing, Humans, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, Transcription factor, QD1-999, Spectroscopy, Gene knockdown, Organic Chemistry, Interleukin-17, Twist-Related Protein 1, IL17, Nuclear Proteins, General Medicine, Computer Science Applications, Gene Expression Regulation, Neoplastic, Chemistry, Cancer research, gene expression, Female, Signal transduction, Signal Transduction, Twist1
Abstract

Breast cancer (BC) is a heterogeneous disease composed of multiple subtypes with different molecular characteristics and clinical outcomes. The metastatic process in BC depends on the transcription factors (TFs) related to epithelial-mesenchymal transition (EMT), including the master regulator Twist1. However, its role beyond EMT in BC subtypes remains unclear. Our study aimed to investigate the role of Twist1, beyond EMT, in the molecular subtypes of BC. In patients, we observed the overexpression of TWIST1 in the HER2+ group. The silencing of TWIST1 in HER2+ BC cells resulted in the upregulation of 138 genes and the downregulation of 174 genes compared to control cells in a microarray assay. In silico analysis revealed correlations between Twist1 and important biological processes such as the Th17-mediated immune response, suggesting that Twist1 could be relevant for IL-17 signaling in HER2+ BC. IL-17 signaling was then examined, and it was shown that TWIST1 knockdown caused the downregulation of leading members of IL-17 signaling pathway. Taken together, our findings suggest that Twist1 plays a role on IL-17 signaling in HER2+ BC.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results