1. A Review on the Role of miR-149-5p in the Carcinogenesis
- Author
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Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Kadkhoda, Sepideh, Taheri, Mohammad, and Tafrishinejad, Arash
- Subjects
Carcinogenesis ,QH301-705.5 ,ncRNAs ,Review ,miR-149-5p ,Disease Models, Animal ,MicroRNAs ,Chemistry ,Gene Ontology ,Cell Line, Tumor ,expression ,Animals ,Humans ,cancer ,biomarker ,Gene Regulatory Networks ,Genes, Tumor Suppressor ,Biology (General) ,QD1-999 - Abstract
miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.
- Published
- 2022