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Start Over Author "Ferrucci, Veronica" Journal international journal of molecular sciences
5 results on '"Ferrucci, Veronica"'

1. Targeting Group 3 Medulloblastoma by the Anti-PRUNE-1 and Anti-LSD1/KDM1A Epigenetic Molecules

Author

Bibbò, Francesca, primary, Asadzadeh, Fatemeh, additional, Boccia, Angelo, additional, Sorice, Carmen, additional, Bianco, Orazio, additional, Saccà, Carmen Daniela, additional, Majello, Barbara, additional, Donofrio, Vittoria, additional, Bifano, Delfina, additional, De Martino, Lucia, additional, Quaglietta, Lucia, additional, Cristofano, Adriana, additional, Covelli, Eugenio Maria, additional, Cinalli, Giuseppe, additional, Ferrucci, Veronica, additional, De Antonellis, Pasqualino, additional, and Zollo, Massimo, additional

Published
2024
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2. A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab

Author

Passariello, Margherita, primary, Ferrucci, Veronica, additional, Sasso, Emanuele, additional, Manna, Lorenzo, additional, Lembo, Rosa Rapuano, additional, Pascarella, Stefano, additional, Fusco, Giovanna, additional, Zambrano, Nicola, additional, Zollo, Massimo, additional, and De Lorenzo, Claudia, additional

Published
2022
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4. Loss of Detection of sgN Precedes Viral Abridged Replication in COVID-19-Affected Patients—A Target for SARS-CoV-2 Propagation

Author

Ferrucci, Veronica, primary, de Antonellis, Pasqualino, additional, Quarantelli, Fabrizio, additional, Asadzadeh, Fatemeh, additional, Bibbò, Francesca, additional, Siciliano, Roberto, additional, Sorice, Carmen, additional, Pisano, Ida, additional, Izzo, Barbara, additional, Di Domenico, Carmela, additional, Boccia, Angelo, additional, Vargas, Maria, additional, Pierri, Biancamaria, additional, Viscardi, Maurizio, additional, Brandi, Sergio, additional, Fusco, Giovanna, additional, Cerino, Pellegrino, additional, De Pietro, Livia, additional, Furfaro, Ciro, additional, Napolitano, Leonardo Antonio, additional, Paolella, Giovanni, additional, Festa, Lidia, additional, Marzinotto, Stefania, additional, Conte, Maria Concetta, additional, Gentile, Ivan, additional, Servillo, Giuseppe, additional, Curcio, Francesco, additional, de Cristofaro, Tiziana, additional, Broccolo, Francesco, additional, Capoluongo, Ettore, additional, and Zollo, Massimo, additional

Published
2022
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5. A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab

Author

Margherita Passariello, Veronica Ferrucci, Emanuele Sasso, Lorenzo Manna, Rosa Rapuano Lembo, Stefano Pascarella, Giovanna Fusco, Nicola Zambrano, Massimo Zollo, Claudia De Lorenzo, Passariello, Margherita, Ferrucci, Veronica, Sasso, Emanuele, Manna, Lorenzo, Lembo, Rosa Rapuano, Pascarella, Stefano, Fusco, Giovanna, Zambrano, Nicola, Zollo, Massimo, and De Lorenzo, Claudia

Subjects
combinatorial treatment, Antibodies, Monoclonal, Humanized, Antibodies, Viral, Catalysis, neutralizing mAb, combinatorial treatments, Inorganic Chemistry, Epitopes, Viral Envelope Proteins, Humans, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, SARS-CoV-2, Organic Chemistry, COVID-19, Antibodies, Monoclonal, Viral Envelope Protein, General Medicine, Omicron variant, neutralizing mAbs, Spike-RBD/ACE-2, Antibodies, Neutralizing, Computer Science Applications, COVID-19 Drug Treatment, Spike Glycoprotein, Coronavirus, Epitope, Spike Glycoprotein, Coronaviru, Human
Abstract

The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein have represented good drugs to interfere in the Spike/ Angiotensin Converting Enzyme-2 (ACE-2) interaction, preventing virus cell entry and subsequent infection, especially in patients with a defective immune system. We obtained, by an innovative phage display selection strategy, specific binders recognizing different epitopes of Spike. The novel human antibodies specifically bind to Spike-Receptor Binding Domain (RBD) in a nanomolar range and interfere in the interaction of Spike with the ACE-2 receptor. We report here that one of these mAbs, named D3, shows neutralizing activity for virus infection in cell cultures by different SARS-CoV-2 variants and retains the ability to recognize the Omicron-derived recombinant RBD differently from the antibodies Casirivimab or Imdevimab. Since anti-Spike mAbs, used individually, might be unable to block the virus cell entry especially in the case of resistant variants, we investigated the possibility to combine D3 with the antibody in clinical use Sotrovimab, and we found that they recognize distinct epitopes and show additive inhibitory effects on the interaction of Omicron-RBD with ACE-2 receptor. Thus, we propose to exploit these mAbs in combinatorial treatments to enhance their potential for both diagnostic and therapeutic applications in the current and future pandemic waves of coronavirus.

Published
2022

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