1. miRNAs and Biomarkers in Testicular Germ Cell Tumors: An Update
- Author
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Paolo Chieffi, Francesco Esposito, Marco De Martino, De Martino, M., Chieffi, P., and Esposito, F.
- Subjects
0301 basic medicine ,Surgical resection ,Adult ,Male ,endocrine system ,Solid cancer ,medicine.medical_treatment ,Review ,Catalysis ,Inorganic Chemistry ,lcsh:Chemistry ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Testicular Neoplasms ,microRNA ,Testis ,Biological fluids ,medicine ,Biomarkers, Tumor ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Testicular cancer ,Chemotherapy ,business.industry ,Organic Chemistry ,Liquid Biopsy ,General Medicine ,Neoplasms, Germ Cell and Embryonal ,medicine.disease ,Prognosis ,Testicular germ cell ,Computer Science Applications ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,030220 oncology & carcinogenesis ,Cancer research ,testicular germ cell tumors ,Biomarker (medicine) ,biomarker ,business - Abstract
Testicular germ cell tumors (TGCTs) are the leading form of solid cancer and death affecting males between the ages of 20 and 40. Today, their surgical resection and chemotherapy are the treatments of first choice, even if sometimes this is not enough to save the lives of patients with TGCT. As seen for several tumors, the deregulation of microRNAs (miRNAs) is also a key feature in TGCTs. miRNAs are small molecules of RNA with biological activity that are released into biological fluids by testicular cancer cells. Their presence, therefore, can be detected and monitored by considering miRNAs as diagnostic and prognostic markers for TGCTs. The purpose of this review is to collect all the studies executed on miRNAs that have a potential role as biomarkers for testicular tumors.
- Published
- 2021