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Your search keyword '"De Pinto, Vito"' showing total 7 results
Start Over Author "De Pinto, Vito" Journal international journal of molecular sciences
7 results on '"De Pinto, Vito"'

2. VDAC1 Knockout Affects Mitochondrial Oxygen Consumption Triggering a Rearrangement of ETC by Impacting on Complex I Activity

Author

Magrì, Andrea, primary, Cubisino, Salvatore Antonio Maria, additional, Battiato, Giuseppe, additional, Lipari, Cristiana Lucia Rita, additional, Conti Nibali, Stefano, additional, Saab, Miriam Wissam, additional, Pittalà, Alessandra, additional, Amorini, Angela Maria, additional, De Pinto, Vito, additional, and Messina, Angela, additional

Published
2023
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3. Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry

Author

Pittalà, Maria Gaetana Giovanna, primary, Reina, Simona, additional, Nibali, Stefano Conti, additional, Cucina, Annamaria, additional, Cubisino, Salvatore Antonio Maria, additional, Cunsolo, Vincenzo, additional, Amodeo, Giuseppe Federico, additional, Foti, Salvatore, additional, De Pinto, Vito, additional, Saletti, Rosaria, additional, and Messina, Angela, additional

Published
2022
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7. VDAC—A Primal Perspective.

Author

Mannella, Carmen A. and De Pinto, Vito

Subjects
*PROTEIN precursors, *CELLULAR evolution, *EUKARYOTIC cells, *ADENOSINE triphosphate, *BIOLOGICAL transport
Abstract

The evolution of the eukaryotic cell from the primal endosymbiotic event involved a complex series of adaptations driven primarily by energy optimization. Transfer of genes from endosymbiont to host and concomitant expansion (by infolding) of the endosymbiont's chemiosmotic membrane greatly increased output of adenosine triphosphate (ATP) and placed selective pressure on the membrane at the host–endosymbiont interface to sustain the energy advantage. It is hypothesized that critical functions at this interface (metabolite exchange, polypeptide import, barrier integrity to proteins and DNA) were managed by a precursor β-barrel protein ("pβB") from which the voltage-dependent anion-selective channel (VDAC) descended. VDAC's role as hub for disparate and increasingly complex processes suggests an adaptability that likely springs from a feature inherited from pβB, retained because of important advantages conferred. It is proposed that this property is the remarkable structural flexibility evidenced in VDAC's gating mechanism, a possible origin of which is discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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