1. Therapeutic Potential of Human Fetal Mesenchymal Stem Cells in Musculoskeletal Disorders: A Narrative Review
- Author
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Insun Song, Jongseop Rim, Jaemin Lee, Inseok Jang, Bosung Jung, Kisoo Kim, and Soonchul Lee
- Subjects
mesenchymal stem cells ,QH301-705.5 ,Human Embryonic Stem Cells ,Organic Chemistry ,General Medicine ,fetal ,Catalysis ,Computer Science Applications ,Immunomodulation ,Inorganic Chemistry ,Chemistry ,Treatment Outcome ,regeneration ,Animals ,Humans ,Musculoskeletal Diseases ,musculoskeletal disorders ,Biology (General) ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Spectroscopy - Abstract
Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for diverse diseases and injuries. The biological and clinical advantages of human fetal MSCs (hfMSCs) have recently been reported. In terms of promising therapeutic approaches for diverse diseases and injuries, hfMSCs have gained prominence as healing tools for clinical therapies. Therefore, this review assesses not the only biological advantages of hfMSCs for healing human diseases and regeneration, but also the research evidence for the engraftment and immunomodulation of hfMSCs based on their sources and biological components. Of particular clinical relevance, the present review also suggests the potential therapeutic feasibilities of hfMSCs for musculoskeletal disorders, including osteoporosis, osteoarthritis, and osteogenesis imperfecta.
- Published
- 2022
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