1. Cytotoxicity evaluation of a new set of 2-aminobenzo[de]iso-quinoline-1,3-diones.
- Author
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Al-Salahi R, Alswaidan I, and Marzouk M
- Subjects
- Cell Death drug effects, Hep G2 Cells, Humans, MCF-7 Cells, Quinolines chemical synthesis, Quinolines chemistry, Quinolines toxicity, Toxicity Tests
- Abstract
A new series of 2-amino-benzo[de]isoquinoline-1,3-diones was synthesized and fully characterized in our previous paper. Here, their cytotoxic effects have been evaluated in vitro in relation to colon HCT-116, hepatocellular Hep-G2 and breast MCF-7 cancer cell lines, using a crystal violet viability assay. The IC50-values of the target compounds are reported in µg/mL, using doxorubicin as a reference drug. The findings revealed that compounds 14, 15, 16, 21 and 22 had significant cytotoxic effects against HCT-116, MCF-7 and Hep-G2 cell lines. Their IC50 values ranged between 1.3 and 8.3 μg/mL in relation to doxorubicin (IC50 ≈ 0.45-0.89 μg/mL). Therefore, these compounds could be used as templates for furthering the development and design of more potent antitumor agents through structural modification.
- Published
- 2014
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