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Start Over Author "Alessia Nottegar" Journal international journal of molecular sciences
2 results on '"Alessia Nottegar"'

1. The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Author

Ilaria Girolami, Nicola Veronese, Lee Smith, Maria G. Caruso, Rosa Reddavide, Gioacchino Leandro, Jacopo Demurtas, and Alessia Nottegar

Subjects
Smad2, TGF-β, pSmad2, phosphorylation, signaling, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which was meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05−2.37, p = 0.029, I2 = 84%), also after having adjusted for potential confounders (RR, 1.65; 95% CI, 1.24−2.18; p < 0.001; I2 = 4%). This finding highlights the importance of the TGF-β signaling in this type of cancer. In this line, further studies are needed to explore more in depth this important molecular pathway, focusing also on potential therapeutic strategies based on its effectors or molecular targets.

Published
2019
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2. The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Author

Alessia Nottegar, Gioacchino Leandro, Nicola Veronese, Rosa Reddavide, Ilaria Girolami, Lee Smith, Jacopo Demurtas, Maria Gabriella Caruso, Girolami, I., Veronese, N., Smith, L., Caruso, M.G., Reddavide, R., Leandro, G., Demurtas, J., and Nottegar, A.

Subjects
TGF-β, 0301 basic medicine, Oncology, medicine.medical_specialty, Smad2 Protein, Review, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta, Internal medicine, Odds Ratio, medicine, Humans, In patient, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Gastrointestinal Neoplasms, biology, phosphorylation, business.industry, Organic Chemistry, Confounding, Cancer, General Medicine, Transforming growth factor beta, Prognosis, medicine.disease, Computer Science Applications, 030104 developmental biology, Increased risk, lcsh:Biology (General), lcsh:QD1-999, pSmad2, 030220 oncology & carcinogenesis, Meta-analysis, biology.protein, Phosphorylation, signaling, business, Publication Bias, Biomarkers, Smad2, Signal Transduction, Transforming growth factor
Abstract

Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which was meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05–2.37, p = 0.029, I2 = 84%), also after having adjusted for potential confounders (RR, 1.65; 95% CI, 1.24–2.18; p < 0.001; I2 = 4%). This finding highlights the importance of the TGF-β signaling in this type of cancer. In this line, further studies are needed to explore more in depth this important molecular pathway, focusing also on potential therapeutic strategies based on its effectors or molecular targets. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2019

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