1. Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
- Author
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David I. Leavesley, Tony J. Parker, Dominic Guanzon, and Uyen Thi Trang Than
- Subjects
0301 basic medicine ,Keratinocytes ,Cell type ,Angiogenesis ,proliferation ,wound healing ,Review ,exosomes ,Cell Communication ,Biology ,migration ,extracellular membrane vesicles ,Catalysis ,Inorganic Chemistry ,Extracellular matrix ,lcsh:Chemistry ,03 medical and health sciences ,angiogenesis ,Cicatrix ,Extracellular Vesicles ,Extracellular ,Animals ,Humans ,Physical and Theoretical Chemistry ,apoptotic bodies ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Cell Proliferation ,Tube formation ,Organic Chemistry ,Cell migration ,General Medicine ,Microvesicles ,endothelial cells ,Computer Science Applications ,Cell biology ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Wound healing ,microvesicles - Abstract
Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derived from the parental cells. Recently, several studies have demonstrated that EVs can regulate many biological processes, such as cancer progression, the immune response, cell proliferation, cell migration and blood vessel tube formation. This regulation is achieved through the release and transport of EVs and the transfer of their parental cell-derived molecular cargo to recipient cells. This thereby influences various physiological and sometimes pathological functions within the target cells. While intensive investigation of EVs has focused on pathological processes, the involvement of EVs in normal wound healing is less clear; however, recent preliminarily investigations have produced some initial insights. This review will provide an overview of EVs and discuss the current literature regarding the role of EVs in wound healing, especially, their influence on coagulation, cell proliferation, migration, angiogenesis, collagen production and extracellular matrix remodelling.
- Published
- 2017