1. Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis
- Author
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Turpin, Chloé, Catan, Aurélie, Meilhac, Olivier, Bourdon, Emmanuel, Canonne-Hergaux, François, Rondeau, Philippe, Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ministère de l’Enseignement Supérieur et de la Recherche, Université de La Réunion, European Regional Development Funds : RE0001897, the Structure fédérative de recherche biosécurité en milieu tropical (BIOST), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and SEGUIN, Nathalie
- Subjects
Erythrocytes ,Meilhac ,QH301-705.5 ,Rondeau ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Review ,Heme ,O ,Hemolysis ,C ,Hemoglobins ,iron ,A ,eryptosis ,E ,Animals ,Humans ,Turpin ,Biology (General) ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology ,QD1-999 ,[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Erythrocyte Membrane ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,Atherosclerosis ,Bourdon ,erythrophagocytosis ,haemoglobin ,Canonne-Hergaux ,Chemistry ,Oxidative Stress ,F ,Cytophagocytosis ,Catan ,glycation ,Disease Progression ,Disease Susceptibility ,P atherosclerosis ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Biomarkers - Abstract
International audience; The development and progression of atherosclerosis (ATH) involves lipid accumulation, oxidative stress and both vascular and blood cell dysfunction. Erythrocytes, the main circulating cells in the body, exert determinant roles in the gas transport between tissues. Erythrocytes have long been considered as simple bystanders in cardiovascular diseases, including ATH. This review highlights recent knowledge concerning the role of erythrocytes being more than just passive gas carriers, as potent contributors to atherosclerotic plaque progression. Erythrocyte physiology and ATH pathology is first described. Then, a specific chapter delineates the numerous links between erythrocytes and atherogenesis. In particular, we discuss the impact of extravasated erythrocytes in plaque iron homeostasis with potential pathological consequences. Hyperglycaemia is recognised as a significant aggravating contributor to the development of ATH. Then, a special focus is made on glycoxidative modifications of erythrocytes and their role in ATH. This chapter includes recent data proposing glycoxidised erythrocytes as putative contributors to enhanced atherothrombosis in diabetic patients.
- Published
- 2021