1. Low-Level Expression of p-S6 Is Associated with Nodal Metastasis in Patients with Head and Neck Cutaneous Squamous Cell Carcinoma.
- Author
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Gómez-de Castro, Celia, Santos-Juanes, Raquel, Nuñez-Gómez, Borja, Fernández-Vega, Iván, Vivanco, Blanca, Fernández-Velasco, Adela, Reyes-García, Sebastián, Carrero-Martín, Jimena, García-Pedrero, Juana M., Rodrigo, Juan P., González-Vela, María del Carmen, Santos-Juanes, Jorge, and Galache, Cristina
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NECK ,SQUAMOUS cell carcinoma ,PROPORTIONAL hazards models ,METASTASIS ,KAPLAN-Meier estimator ,RIBOSOMAL proteins - Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. The incidence of metastasis for cSCC is estimated to be around 1.2–5%. Ribosomal protein S6 (p-S6) and the p21 protein (p21) are two proteins that play central roles in other cancers. These proteins may be equally important in cSCC, and together, these could constitute a good candidate for metastasis risk assessment of these patients. We investigate the relationship of p-S6 and p21 expression with the impact on the prognosis of head and neck cSCC (cSCCHN). p-S6 and p21 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 116 patients with cSCCHN and associations sought with clinical characteristics. Kaplan–Meier estimators and Cox proportional hazard regression models were also used. The expression of p-S6 was significantly inversely associated with tumor thickness, tumor size, desmoplastic growth, pathological stage, perineural invasion and tumor buds. p21 expression was significantly inversely correlated with >6 mm tumor thickness, desmoplastic growth, and perineural invasion. p-S6-negative expression significantly predicted an increased risk of nodal metastasis (HR = 2.63, 95% CI 1.51–4.54; p < 0.001). p21 expression was not found to be a significant risk factor for nodal metastasis. These findings demonstrate that p-S6-negative expression is an independent predictor of nodal metastasis. The immunohistochemical expression of p-S6 might aid in better risk stratification and management of patients with cSCCHN. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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