1. Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons
- Author
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Cheng-Fu Kao, Chu Yuan Chang, Jui-Hung Hung, Ka Shing Fung, Joye Li, Linyi Chen, and Liang Wei Huang
- Subjects
enhancer regulation ,Chromatin Immunoprecipitation ,epigenome ,Methylation ,Catalysis ,Article ,Epigenesis, Genetic ,lcsh:Chemistry ,Inorganic Chemistry ,Histones ,Rats, Sprague-Dawley ,Histone H3 ,Wnt3A Protein ,Brain Injuries, Traumatic ,Transcriptional regulation ,Animals ,Regeneration ,histone modification ,transcriptional regulation ,Epigenetics ,Physical and Theoretical Chemistry ,Enhancer ,Promoter Regions, Genetic ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Neurons ,neuronal regeneration ,biology ,Organic Chemistry ,Acetylation ,General Medicine ,Epigenome ,Computer Science Applications ,Chromatin ,Cell biology ,Rats ,Disease Models, Animal ,Histone ,Enhancer Elements, Genetic ,lcsh:Biology (General) ,lcsh:QD1-999 ,biology.protein ,H3K4me3 ,WNT3A - Abstract
Traumatic brain injury is known to reprogram the epigenome. Chromatin immunoprecipitation-sequencing of histone H3 lysine 27 acetylation (H3K27ac) and tri-methylation of histone H3 at lysine 4 (H3K4me3) marks was performed to address the transcriptional regulation of candidate regeneration-associated genes. In this study, we identify a novel enhancer region for induced WNT3A transcription during regeneration of injured cortical neurons. We further demonstrated an increased mono-methylation of histone H3 at lysine 4 (H3K4me1) modification at this enhancer concomitant with a topological interaction between sub-regions of this enhancer and with promoter of WNT3A gene. Together, this study reports a novel mechanism for WNT3A gene transcription and reveals a potential therapeutic intervention for neuronal regeneration.
- Published
- 2020