1. Apoptosis Disorder, a Key Pathogenesis of HCMV-Related Diseases.
- Author
-
Yu, Zhongjie, Wang, Yashuo, Liu, Lili, Zhang, Xianjuan, Jiang, Shasha, and Wang, Bin
- Subjects
- *
HUMAN cytomegalovirus - Abstract
Human cytomegalovirus (HCMV) belongs to the β-herpesvirus family, which is transmitted in almost every part of the world and is carried by more than 90% of the general population. Increasing evidence indicates that HCMV infection triggers numerous diseases by disrupting the normal physiological activity of host cells, particularly apoptosis. Apoptosis disorder plays a key role in the initiation and development of multiple diseases. However, the relationship and molecular mechanism of HCMV-related diseases and apoptosis have not yet been systematically summarized. This review aims to summarize the role of apoptosis in HCMV-related diseases and provide an insight into the molecular mechanism of apoptosis induced by HCMV infection. We summarize the literature on HCMV-related diseases and suggest novel strategies for HCMV treatment by regulating apoptosis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF