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Start Over Author "R, Tomonari" Journal international journal of molecular medicine
2 results on '"R, Tomonari"'

1. The possible intraspousal transmission of HCV in terms of lichen planus

Author

Y, Nagao, R, Tomonari, M, Kage, K, Komai, K, Tsubone, T, Kamura, and M, Sata

Subjects
Adult, Aged, 80 and over, Male, Lichen Planus, Middle Aged, Hepatitis C, Sexual Partners, Japan, Risk Factors, Humans, Female, Spouses, Genital Diseases, Female, Aged, Lichen Planus, Oral
Abstract

Lichen planus (LP), common mucocutaneous disorder, involves not only oral mucosa and skin but genitalia membrane. LP is frequently seen in patients with HCV infection. This study evaluated patients with HCV-associated oral lichen planus (OLP) for vulvar and vaginal LP involvement, and the possible intraspousal transmission of HCV. We examined a total of 24 female Japanese patients with OLP for genitalia LP: 14 OLP-HCV positive and 10 OLP-HCV negative. All subjects were evaluated for genital LP by a gynecologist. All 24 subjects and 10 of the husbands were tested for anti-HCV and serum HCV RNA. Vulvar LP was observed in 10 (41.7%) of 24 patients with OLP. Vulvar LP in 14 (OLP-HCV positive) and 10 patients (OLP-HCV negative) were observed in 42.9 and 40%, respectively. There were no significant differences (age, sites of OLP, blood transfusion, HCV infection, and degree of liver diseases) between the vulvar LP and non-vulvar LP patients. Two spouses of 10 married couples were shown to be infected with HCV. In one couple with HCV infection, the wife and husband had also erosive OLP, the wife had erosive vulvar LP. In conclusion, the majority of OLP patients suffered from genitalia LP in Japan. Clinicians should follow the OLP patients with sufficient attention to the presence of extraoral manifestations. These data may suggest the occurrence of intraspousal transmission of HCV through erosive vulvar LP.

Published
2002

2. The possible intraspousal transmission of HCV in terms of lichen planus.

Author

Nagao Y, Tomonari R, Kage M, Komai K, Tsubone K, Kamura T, and Sata M

Subjects
Adult, Aged, Aged, 80 and over, Female, Genital Diseases, Female complications, Genital Diseases, Female virology, Hepatitis C virology, Humans, Japan, Lichen Planus complications, Lichen Planus virology, Male, Middle Aged, Risk Factors, Sexual Partners, Spouses, Hepatitis C complications, Hepatitis C transmission, Lichen Planus, Oral complications, Lichen Planus, Oral virology
Abstract

Lichen planus (LP), common mucocutaneous disorder, involves not only oral mucosa and skin but genitalia membrane. LP is frequently seen in patients with HCV infection. This study evaluated patients with HCV-associated oral lichen planus (OLP) for vulvar and vaginal LP involvement, and the possible intraspousal transmission of HCV. We examined a total of 24 female Japanese patients with OLP for genitalia LP: 14 OLP-HCV positive and 10 OLP-HCV negative. All subjects were evaluated for genital LP by a gynecologist. All 24 subjects and 10 of the husbands were tested for anti-HCV and serum HCV RNA. Vulvar LP was observed in 10 (41.7%) of 24 patients with OLP. Vulvar LP in 14 (OLP-HCV positive) and 10 patients (OLP-HCV negative) were observed in 42.9 and 40%, respectively. There were no significant differences (age, sites of OLP, blood transfusion, HCV infection, and degree of liver diseases) between the vulvar LP and non-vulvar LP patients. Two spouses of 10 married couples were shown to be infected with HCV. In one couple with HCV infection, the wife and husband had also erosive OLP, the wife had erosive vulvar LP. In conclusion, the majority of OLP patients suffered from genitalia LP in Japan. Clinicians should follow the OLP patients with sufficient attention to the presence of extraoral manifestations. These data may suggest the occurrence of intraspousal transmission of HCV through erosive vulvar LP.

Published
2002

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