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Patients with long‐term disease experience low resilience, emphasising the importance of psychological interventions to improve resilience. However, there is no comprehensive evidence on the efficacy of resilience‐related psychological interventions (RRPIs) in this population. Therefore, we performed a meta‐analysis to evaluate and extend knowledge from previous meta‐analyses on the efficacy of RRPIs on resilience, stress, anxiety, depression and quality of life among patients with long‐term disease. Cochrane Library, Embase, Ovid‐MEDLINE, PubMed, Scopus, Web of Science and CINAHL electronic databases were searched until 3 February 2023. The pooled effect size of the efficacy of RRPIs was calculated using the Hedges' g (g) with random‐effects model, while Cochrane Q‐statistics and I2 tests assessed heterogeneity in Comprehensive Meta‐Analysis 3.0 software. The Cochrane Risk of Bias 2.0 tool evaluated the quality of studies. Moderator analysis was used to explore sources of heterogeneity. Twenty randomised controlled trial studies were identified, representing a total of 1388 individuals with long‐term disease. RRPIs significantly enhance resilience (g = 0.79), alleviate stress (g = −0.78), decrease anxiety (g = −1.14), mitigate depression (g = −0.96) and improve quality of life (g = 0.48). Positive psychology, mindfulness, cognitive behavioural therapy, acceptance and commitment‐based intervention exhibited medium effects in strengthening resilience. Short‐term effects of RRPIs on enhancing resilience were observed at 3‐month follow‐up period (g = 0.50). The incorporation of RRPIs into the management of patients with long‐term disease shows a positive impact on their resilience, stress, anxiety, depression and quality of life. The results offer an evidence‐based foundation for nurses in promoting resilience among patients with long‐term disease. [ABSTRACT FROM AUTHOR]