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Start Over Author "Yinlu Ding" Journal international journal of medical sciences
2 results on '"Yinlu Ding"'

1. Laparoscopic Management of Perforated Meckel's Diverticulum in Adults

Author

Yinlu Ding, Yong Zhou, Zhipeng Ji, Jianliang Zhang, Qisan Wang

Subjects
Medicine
Abstract

Objective: To determine the role of laparoscopy in diagnosis and surgical treatment of perforated Meckel's diverticulum (MD) in adults.Methods: Between July 2003 and July 2011, fifteen patients were seen with perforated MD. Eleven were male and four were female. The median age was 38 years (range, 21-68). All patients presented with a sudden onset of pain. Among them 9 had a past medical history of bloody stools and /or chronic recurrent abdominal pain. 2 were preoperatively diagnosed with perforated MD confirmly and 4 suspiciously, 9 with perforated acute appendicitis. All 15 patients underwent exploratory laparoscopy.Results: 4 patients with broad-base(≧ 2 cm) and 2 patients with narrow-base(Conclusion: To patients with sudden abdomen pain mimic acute appendicitis accompanied by a past medical history of bloody stools and/or chronic recurrent abdominal pain, proferated MD should be kept in mind as a differential diagnosis. Laparoscopy is a safe and effective surgical modality for diagnosis of proferated MD and has a therapeutic role that results in an excellent cosmetic result.

Published
2012

2. Expression of Glioma-associated Oncogene Homolog 1 is Associated with Invasion and Postoperative Liver Metastasis in Colon Cancer

Author

Lei Xiang, Yinlu Ding, Zhou-hong Luo, Zhi-peng Ji, and Yong Zhou

Subjects
Male, Pathology, medicine.medical_specialty, Colorectal cancer, In Vitro Techniques, Zinc Finger Protein GLI1, Metastasis, Downregulation and upregulation, Glioma, Humans, Medicine, Glioma-associated oncogene 1, Lymph node, Proportional Hazards Models, Oncogene, business.industry, Liver Neoplasms, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Liver metastasis, medicine.anatomical_structure, Colon neoplasm, Tissue Array Analysis, Lymphatic Metastasis, Colonic Neoplasms, Cancer research, Female, business, Transcription Factors, Research Paper
Abstract

Objective: To investigate the expression of glioma-associated oncogene homolog 1(Gli-1) in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis. Methods: Expression of Gli-1 was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between Gli-1 expression and clinicopathological parameters, postoperative liver metastasis were analyzed. Results: Gli-1 protein expression was significantly increased in colon cancer tissues compared to normal colon tissues (P = 0.037). Gli-1 expression in colon tissues was increased in patients with lymph node metastases (P = 0.022) and higher T stages (P = 0.030). Postoperative live metastasis-free survival period was significantly longer in low Gli-1 expression group than that of high Gli-1 expression group (48.22±10.03 months vs 20.46±6.32 months, P=0.001). Multivariate analysis showed that Gli-1 expression level is an independent prognostic factor for postoperative live metastasis-free survival. Conclusion: Colon cancer is associated with an upregulation of Gli-1 protein expression in colon tissues. In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.

Published
2012

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