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Background: The aim of the present study was to study the effect of percutaneous balloon mitral valvuloplasty (PBMV) on P wave dispersion and to test the correlation between P-maximum and P-dispersion to right ventricular function and pulmonary artery pressure before and after PMBV. Also to study the impact of P-maximum and P-wave dispersion on the short term clinical outcome after successful PBMV in patients with mitral stenosis (MS) and sinus rhythm. Methods: 75 patients undergoing PMBV were enrolled in this study. We evaluated P-maximum, P-minimum and P-wave dispersion before and one month and one year after PBMV . We studied the changes in pulmonary arterial pressure (PAP), left atrial (LA) dimension, mitral diastolic gradient, and mitral valve area, in addition to the changes in right ventricular function utilizing tissue Doppler assessment both before and after PMBV, in addition the role of the P-wave dispersion in prediction of late cardiac events. Results: There were significant decrease in mean diastolic gradient, PAP, and LA size and significant improvement in right ventricular tissue Doppler indices after PMBV. Accompany these hemodynamic changes after PMBV. P-maximum and P-wave dispersion were found to be decreased (P < 0.001). Conclusion: Successful PBMV was associated with a decrease in Pmax and PWD. These simple electrocardiographic indices may predict the success of the procedure immediately after PBMV. The P-maximum and P-wave dispersion changes were correlated with significant impairment of right dysfunction and the degree of pulmonary artery pressure. Keywords: PBMV.PAP,LA

Background: Patients of coronary artery disease require medical treatment to optimize their lipid profile. The present analysis evaluates the lipid profile among CAD patients receiving statin therapy. To study THE STATUS OF LIPID PROFILE CONTROL IN CORONARY ARTERY DISEASE PATIENTS AT A TERTIARY CARE HOSPITAL Methods: Our study included 1016 patients with documented CAD by coronary angiography in Department of cardiology SMS medical college and associated group of hospitals. Patients treated with statin therapy for at least 3 months were included. We compared data relating to demographic parameters and other cardiovascular risk factors. Results: In a total of 1016 patients (730 males and 286 females), (mean age 57.2 ± 8.8 years). Complete lipid profiles of 1016 patients were recorded. Regarding the CAD patients with complete lipid profiles, 72% had lag in lipid profile control as against the current guidelines in at least one of the three main lipid parameters: low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and/or triglycerides. LDLc was not within target levels in 64.2% of these high risk patients; HDLc was abnormal in 35%, and triglycerides were elevated in 25% despite monthly follow up at the opd. Conclusion: Most of the patients treated with statins, especially those with a high cardiovascular risk, do not meet recommended lipid targets and/or have a high frequency of abnormal HDLc and TG levels. The results of this study show that significant differences exist between the recommendations in the guidelines and clinical practice, as well as highlighting the need for a more intensive and integrated management of dyslipidemia in high-risk patients. Keywords: Lipid profile, CAD, Lipoprotein