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The article presents a study which compared three different Normal Pooled Plasmas (NPPs) such as homemade, commercial frozen, and lyophilized, with all platform-reagent combinations used for lupus anticoagulant (LA) detection in the Piedmont region. Topics discussed include one of the major issues in LA detection of laboratories, LA classification, and comparison of dilute Russel Viper Venom Time (DRVVT) screening ratios.

The article presents a case study of an 8-year-old patient with symptoms of malaria and it discusses the infected red blood cells flag (InR) of the Mindray BC 6800 plus. It reports on the identification of malaria-infected red blood cells, which aids in diagnosis, and it mentions the use of rapid malaria testing to detect malaria antigens. It highlights the importance of monitoring parasitemia during treatment to confirm the patient's response to therapy.

Introduction: Despite the important diagnostic role of peripheral blood morphology, cell classification is subjective. Automated image-processing systems (AIS) provide more accurate and objective morphological evaluation. The aims of this multicenter study were the evaluation of the intra and inter-laboratory variation between different AIS in cell pre-classification and after reclassification, compared with manual optical microscopy, the reference method. Methods: Six peripheral blood samples were included in this study, for each sample, 70 May-Grunwald and Giemsa stained PB smears were prepared from each specimen and 10 slides were delivered to the seven laboratories involved. Smears were processed by both optical microscopy (OM) and AIS. In addition, the assessment times of both methods were recorded. Results: Within-laboratory Reproducibility ranged between 4.76% and 153.78%; between-laboratory Precision ranged between 2.10% and 82.2%, while Total Imprecision ranged between 5.21% and 20.60%. The relative Bland Altman bias ranged between -0.01% and 20.60%. The mean of assessment times were 326 ± 110 s and 191 ± 68 s for AIS post reclassification and OM, respectively. Conclusions: AIS can be helpful when the number of cell counted are low and can give advantages in terms of efficiency, objectivity and time saving in the morphological analysis of blood cells. They can also help in the interpretation of some morphological features and can serve as learning and investigation tools. [ABSTRACT FROM AUTHOR]

The article discusses research which investigated the link between B lymphocyte activity and mortality of patients with coronavirus disease 2019 (COVID-19). Topics explored include the use of the Sysmex XN-2000™ Haematology System to analyze the haematological parameters of COVID-19 patients, the demographic and laboratory data of patients involved in the study, and other predictors of in-hospital COVID-19-related mortality such as age, creatinine, and C-reactive protein.

This article, published in the International Journal of Laboratory Hematology, presents a case report of a 50-year-old Caucasian woman with a suspected lymphoproliferative disorder. The patient had symptoms of abdominal distension, early satiety, and weight loss. Laboratory analysis revealed abnormalities in white blood cell count, hemoglobin level, platelet count, and cell damage indices. The detection of immature cells in the blood smear and flow cytometric analysis confirmed a diagnosis of CD5+ splenic marginal zone lymphoma. The article highlights the diagnostic challenges and the need for further research in the field. [Extracted from the article]