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Your search keyword '"Mascolo M"' showing total 6 results
Start Over Author "Mascolo M" Journal international journal of immunopathology and pharmacology
6 results on '"Mascolo M"'

1. Helicobacter PyloriHP(2–20) Induces Eosinophil Activation and Accumulation in Superficial Gastric Mucosa and Stimulates VEGF-α and TGF-β Release by Interacting with Formyl-Peptide Receptors

Author

Prevete, N., primary, Rossi, F.W., additional, Rivellese, F., additional, Lamacchia, D., additional, Pelosi, C., additional, Lobasso, A., additional, Necchi, V., additional, Solcia, E., additional, Fiocca, R., additional, Ceppa, P., additional, Staibano, S., additional, Mascolo, M., additional, D'Argenio, G., additional, Romano, M., additional, Ricci, V., additional, Marone, G., additional, and De Paulis, A., additional

Published
2013
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3. Squamous Cell Carcinoma of the Lower LIP: Fas/Fasl Expression, Lymphocyte Subtypes and Outcome

Author

Somma, P., primary, Lo Muzio, L., additional, Mansueto, G., additional, Delfino, M., additional, Fabbrocini, G., additional, Mascolo, M., additional, Mignogna, C., additional, Di Benedetto, M., additional, Carinci, F., additional, De Lillo, A., additional, Pastore, L., additional, Serpico, R., additional, De Rosa, G., additional, and Staibano, S., additional

Published
2005
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4. Helicobacter PyloriHP(2–20) Induces Eosinophil Activation and Accumulation in Superficial Gastric Mucosa and Stimulates VEGF-a and TGF-ß Release by Interacting with Formyl-Peptide Receptors

Author

Prevete, N., Rossi, F.W., Rivellese, F., Lamacchia, D., Pelosi, C., Lobasso, A., Necchi, V., Solcia, E., Fiocca, R., Ceppa, P., Staibano, S., Mascolo, M., D'Argenio, G., Romano, M., Ricci, V., Marone, G., and De Paulis, A.

Abstract

Eosinophils participate in the immune response against Helicobacter pylori, but little is known about their role in the gastritis associated to the infection. We recently demonstrated that the Hp(2–20) peptide derived from H. pyloriaccelerates wound healing of gastric mucosa by interacting with N-formylpeptide receptors (FPRs) expressed on gastric epithelial cells. The aim of the present study was to investigate whether eosinophils play a role in the repair of gastric mucosa tissue during H. pyloriinfection. Immunohistochemistry and transmission electron microscopy were used to detect eosinophils in gastric mucosal biopsies. Eosinophil re-distribution occurred in the gastric mucosa of H. pylori-infected patients: their density did not change in the deep mucosal layer, whereas it increased in the superficial lamina propria just below the foveolar epithelium; eosinophils entered the epithelium itself as well as the lumen of foveolae located close to the area harboring bacteria, which in turn were also engulfed by eosinophils. The H. pylori-derived peptide Hp(2–20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-ß, two key mediators of tissue remodeling. We also demonstrate that Hp(2–20) in vivoinduced eosinophil infiltration in rat gastric mucosa after injury brought about by indomethacin. This study suggests that eosinophil infiltrate could modulate the capacity of gastric mucosa to maintain or recover its integrity thereby shedding light on the role of eosinophils in H. pyloriinfection.

Published
2013
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5. Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors

Author

Gianni Marone, Francesca Wanda Rossi, Vittorio Necchi, Vittorio Ricci, Massimo Mascolo, Roberto Fiocca, Stefania Staibano, D. Lamacchia, Paola Ceppa, A. De Paulis, Enrico Solcia, A. Lobasso, Felice Rivellese, N. Prevete, Maurizio Romano, Giuseppe D'Argenio, C. Pelosi, N., Prevete, F. W., Rossi, F., Rivellese, D., Lamacchia, C., Pelosi, A., Lobasso, V., Necchi, E., Solcia, R., Fiocca, P., Ceppa, S., Staibano, M., Mascolo, G., D’Argenio, Romano, Marco, V., Ricci, G., Marone, A., de Paulis, Prevete, Nella, Rossi, FRANCESCA WANDA, Rivellese, Felice, Lamacchia, Donatella, Pelosi, Chiara, Lobasso, Antonio, Necchi, V, Solcia, E, Fiocca, R, Ceppa, P, Staibano, Stefania, Mascolo, Massimo, D., Argenio G, Romano, M, Ricci, V, Marone, Gianni, DE PAULIS, Amato, Prevete, N., Rossi, F. W., Rivellese, F., Lamacchia, D., Pelosi, C., Lobasso, A., Necchi, V., Solcia, E., Fiocca, R., Ceppa, P., Staibano, S., Mascolo, M., D'Argenio, G., Romano, M., Ricci, V., Marone, G., and De Paulis, A.

Subjects
Formyl peptide, Male, Vascular Endothelial Growth Factor A, Indomethacin, FPRs, Eosinophil, Hp(2-20), Peptide Fragment, Eosinophils, Helicobacter pylori, Transforming Growth Factor beta, Immunology and Allergy, Receptors, Lipoxin, Receptor, Cells, Cultured, biology, Chemistry, Immunohistochemistry, Chemotaxis, Leukocyte, medicine.anatomical_structure, Gastritis, FPR, medicine.symptom, Case-Control Studie, Human, Signal Transduction, Immunology, Bacterial Protein, Helicobacter Infections, Immune system, Bacterial Proteins, Microscopy, Electron, Transmission, TGF beta signaling pathway, Eosinophil activation, Gastric mucosa, medicine, Animals, Humans, RNA, Messenger, Stomach Ulcer, Rats, Wistar, Pharmacology, Animal, Gastriti, biology.organism_classification, Molecular biology, Receptors, Formyl Peptide, Peptide Fragments, Rats, Disease Models, Animal, Gastric Mucosa, Case-Control Studies, Chronic Disease, Rat, Helicobacter Infection
Abstract

Eosinophils participate in the immune response against Helicobacter pylori, but little is known about their role in the gastritis associated to the infection. We recently demonstrated that the Hp(2-20) peptide derived from H. pylori accelerates wound healing of gastric mucosa by interacting with N-formyl peptide receptors (FPRs) expressed on gastric epithelial cells. The aim of the present study was to investigate whether eosinophils play a role in the repair of gastric mucosa tissue during H. pylori infection. Immunohistochemistry and transmission electron microscopy were used to detect eosinophils in gastric mucosal biopsies. Eosinophil re-distribution occurred in the gastric mucosa of H. pylori-infected patients: their density did not change in the deep mucosal layer, whereas it increased in the superficial lamina propria just below the foveolar epithelium; eosinophils entered the epithelium itself as well as the lumen of foveolae located close to the area harboring bacteria, which in turn were also engulfed by eosinophils. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-β, two key mediators of tissue remodeling. We also demonstrate that Hp(2-20) in vivo induced eosinophil infiltration in rat gastric mucosa after injury brought about by indomethacin. This study suggests that eosinophil infiltrate could modulate the capacity of gastric mucosa to maintain or recover its integrity thereby shedding light on the role of eosinophils in H. pylori infection. Copyright © by BIOLIFE, s.a.s.

Published
2013

6. Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.

Author

Prevete N, Rossi FW, Rivellese F, Lamacchia D, Pelosi C, Lobasso A, Necchi V, Solcia E, Fiocca R, Ceppa P, Staibano S, Mascolo M, D'Argenio G, Romano M, Ricci V, Marone G, and De Paulis A

Subjects
Animals, Case-Control Studies, Cells, Cultured, Chemotaxis, Leukocyte, Chronic Disease, Disease Models, Animal, Eosinophils immunology, Eosinophils microbiology, Eosinophils ultrastructure, Gastric Mucosa immunology, Gastric Mucosa microbiology, Gastric Mucosa ultrastructure, Gastritis immunology, Gastritis microbiology, Gastritis pathology, Helicobacter Infections complications, Helicobacter Infections immunology, Helicobacter Infections microbiology, Helicobacter Infections pathology, Helicobacter pylori immunology, Humans, Immunohistochemistry, Indomethacin, Male, Microscopy, Electron, Transmission, RNA, Messenger metabolism, Rats, Rats, Wistar, Receptors, Lipoxin metabolism, Signal Transduction, Stomach Ulcer chemically induced, Stomach Ulcer immunology, Stomach Ulcer metabolism, Stomach Ulcer microbiology, Transforming Growth Factor beta genetics, Vascular Endothelial Growth Factor A genetics, Bacterial Proteins metabolism, Eosinophils metabolism, Gastric Mucosa metabolism, Gastritis metabolism, Helicobacter Infections metabolism, Helicobacter pylori metabolism, Peptide Fragments metabolism, Receptors, Formyl Peptide metabolism, Transforming Growth Factor beta metabolism, Vascular Endothelial Growth Factor A metabolism
Abstract

Eosinophils participate in the immune response against Helicobacter pylori, but little is known about their role in the gastritis associated to the infection. We recently demonstrated that the Hp(2-20) peptide derived from H. pylori accelerates wound healing of gastric mucosa by interacting with N-formyl peptide receptors (FPRs) expressed on gastric epithelial cells. The aim of the present study was to investigate whether eosinophils play a role in the repair of gastric mucosa tissue during H. pylori infection. Immuno-histochemistry and transmission electron microscopy were used to detect eosinophils in gastric mucosal biopsies. Eosinophil re-distribution occurred in the gastric mucosa of H. pylori-infected patients: their density did not change in the deep mucosal layer, whereas it increased in the superficial lamina propria just below the foveolar epithelium; eosinophils entered the epithelium itself as well as the lumen of foveolae located close to the area harboring bacteria, which in turn were also engulfed by eosinophils. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling. We also demonstrate that Hp(2-20) in vivo induced eosinophil infiltration in rat gastric mucosa after injury brought about by indomethacin. This study suggests that eosinophil infiltrate could modulate the capacity of gastric mucosa to maintain or recover its integrity thereby shedding light on the role of eosinophils in H. pylori infection.

Published
2013
Full Text
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