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Your search keyword '"Carraro, S"' showing total 3 results
Start Over Author "Carraro, S" Journal international journal of immunopathology and pharmacology
3 results on '"Carraro, S"'

1. Clinical Application of Nasal Nitric Oxide Measurement

Author

Carraro, S., Cutrone, C., Cardarelli, C., Zanconato, S., and EUGENIO BARALDI

Subjects
Pharmacology, Nasal Mucosa, Rhinitis, Allergic, Perennial, Cystic Fibrosis, Immunology, Humans, Rhinitis, Allergic, Seasonal, Immunology and Allergy, Child, Nitric Oxide, Ciliary Motility Disorders
Abstract

Nitric oxide is present in high concentration in the upper respiratory tract. The main source of this gaseous molecule is the paranasal sinus epithelium. The physiological role of this mediator is to contribute to local host defense, modulate ciliary motility and serve as an aerocrine mediator in helping to maintain adequate ventilation-perfusion matching in the lung. Abnormal values of nasal NO (nNO) have been reported in different pathological conditions of the respiratory tract. Reduced nNO values have been recorded in subjects with acute and chronic sinusitis, cystic fibrosis and nasal polyps. Particularly low concentrations have been described in children with primary ciliary dyskinesia, so nNO measurement has been proposed as a reliable screening test for this chronic lung disease.

Published
2010

3. Impact of oral immunotherapy on quality of life in children with cow milk allergy: a pilot study.

Author

Carraro S, Frigo AC, Perin M, Stefani S, Cardarelli C, Bozzetto S, Baraldi E, and Zanconato S

Subjects
Administration, Oral, Age Factors, Anxiety etiology, Anxiety prevention & control, Child, Child Behavior, Child, Preschool, Emotions, Female, Humans, Italy, Male, Milk Hypersensitivity diagnosis, Milk Hypersensitivity immunology, Milk Hypersensitivity psychology, Milk Proteins immunology, Pilot Projects, Social Behavior, Surveys and Questionnaires, Time Factors, Treatment Outcome, Desensitization, Immunologic methods, Milk Hypersensitivity therapy, Milk Proteins administration & dosage, Quality of Life
Abstract

Quality of life is negatively affected in children with food allergy. Oral immunotherapy is an approach to food allergy that leads to patient desensitization by administering gradually increasing amounts of a given food allergen. The aim of this pilot study is to evaluate how oral immunotherapy affects quality of life in children allergic to cow milk proteins. Thirty children (aged 3-12 years) with cow milk allergy were recruited. Their parents were provided with a validated disease specific quality of life questionnaire (the food allergy quality of life questionnaire -- parent form, FAQLQ-PF) before and again 2 months after completing an oral immunotherapy protocol with cow milk. A significant improvement in all the investigated domains -- emotional impact, food anxiety and social and dietary limitations -- was found. The separate analysis of the different age groups demonstrated that the emotional impact and the food-related anxiety improved in children older than 4, while the social domains improved in each age group. In this pilot experience, oral immunotherapy significantly improves quality of life in children with cow milk allergy. The improvement seems particularly evident in children over 4 years old, who are most likely to benefit from the oral immunotherapy approach. Further placebo-controlled studies are needed to confirm these preliminary results.

Published
2012
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