1. Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients
- Author
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C. B. Filho, F. F. Rodrigues, A. M. Fonseca, J. Araujo, C. Arahata, L. Pontes, L. Vilar, J. L. de, SEGAT, LUDOVICA, CROVELLA, SERGIO, C. B., Filho, F. F., Rodrigue, Segat, Ludovica, A. M., Fonseca, J., Araujo, C., Arahata, L., Ponte, L., Vilar, J. L., De, and Crovella, Sergio
- Subjects
Hashimoto thyroiditis ,Adult ,Male ,MBL2 ,functional polymorphisms ,Brazilian patients ,disease susceptibility ,Adolescent ,Hashimoto Disease ,functional polymorphism ,Mannose-Binding Lectin ,Polymorphism, Single Nucleotide ,Young Adult ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Child ,Genetic Association Studies ,Infant ,Exons ,Middle Aged ,Graves Disease ,Brazilian patient ,Case-Control Studies ,Child, Preschool ,Hashimoto thyroiditi ,Female ,Brazil - Abstract
We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95\% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95\% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.
- Published
- 2012