1. Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort
- Author
-
Hongxi Xiao, Zhijun Zhou, Yang Cao, Chao Feng, Guoquan Wang, Jianqiu Guo, Xiuli Chang, Dasheng Lu, Chunhua Wu, Hao Xu, Jiming Zhang, Xiaojuan Qi, Shenliang Lv, Yubin Zhang, and Weijiu Liang
- Subjects
Male ,China ,Urinary system ,Physiology ,Urine ,010501 environmental sciences ,Endocrine Disruptors ,01 natural sciences ,Gesell Developmental Schedules ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Child Development ,Tandem Mass Spectrometry ,Bayesian multivariate linear regression ,Biomonitoring ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Child ,0105 earth and related environmental sciences ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,Confidence interval ,Triclosan ,chemistry ,Child, Preschool ,Environmental Pollutants ,Female ,business ,Birth cohort - Abstract
Background Early life exposure to triclosan, an emerging endocrine disrupting chemical, may adversely impact childhood neurodevelopment, but limited epidemiologic studies have examined the associations. Objective We evaluated the associations between prenatal and postnatal triclosan exposure and child neurodevelopment at 3 years. Methods The study included 377 mother-child pairs who participated in Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. Triclosan concentrations in maternal and 3-year-old child urine samples were quantified using gas chromatography-tandem mass spectrometry (GC-MS/MS). Gesell Developmental Schedules (GDS) were used to assess child neurodevelopment at 3 years of age. Multivariate linear regression models were applied to estimate associations of prenatal and postnatal urinary triclosan concentrations with children's developmental quotients (DQs). Results Detection frequencies of triclosan in maternal and childhood urine samples were 100% and 99.5%, respectively. The median values of prenatal and postnatal urinary triclosan levels were 0.65 and 0.44 μg/L, respectively. One ln-unit increase of maternal urinary triclosan concentration was associated with increase of DQ scores in motor area of children (regression coefficient, β = 0.28, 95% confidence interval, CI: 0.03, 0.54; p = 0.03). In sex-stratified analyses, maternal urinary triclosan levels were significantly related to increases in DQ scores in motor area among boys (β = 0.25, 95%CI: 0.01, 0.50; p = 0.04), while postnatal urinary triclosan concentrations were inversely associated with DQ scores in social area in boys (β = -0.37, 95%CI: -0.72, -0.03; p = 0.03). Conclusions The findings suggested that prenatal triclosan exposure predicted increases in motor scores, while postnatal triclosan exposure was related to reductions in social scores of 3-year-old children. These associations were only observed in boys. The biological mechanisms linking triclosan exposure to neurodevelopment await further studies.
- Published
- 2019