This paper presents an experimental analysis on the heat transfer and pressure drop enhancement of oil nanofluid flow. In this analysis, the first method has used the helically coiled tube and shell, the oil nanofluids were employed instead of the base fluid (oil) in the second process. the two techniques were used to improve the heat transfer and pressure drop. Nanofluid oil concentrations utilized within range from 1 to 5 percent vol. This paper applied two forms of nanoparticles: copper (Cu (20 nm)) and zirconium oxide (ZrO2 (40 nm)) and base fluid (oil). The influence on the heat transfer coefficient for different factors such as the flow number of Reynolds, the temperature of the nanofluid oil, the concentration and shape of the nanoparticle, and the pressure gradient of the flow have examined. The results indicated that the value of a 40.35 percent in the heat transfer coefficient for Cu + oil and 28.42 percent for ZrO2 + oil increased compared with the base fluid (oil) at 5 percent vol concentration. Using oil nanofluids (Cu, ZrO2 - oil) instead of the base fluid (oil) led to increasing in the heat transfer coefficient and decreasing the pressure. In addition, the result showed that the heat transfer efficiency has enhanced using the helically coiled tube and shell, as well as increasing in the pressure drop was due to the curvature of the tube. Baes on the relationship between viscosity and shear intensity, the oil nanofluid behaviors were similar to the standard Newtonian fluids. Moreover, the related flow and heat transfer methods are used to present the output index. The exergy inflow, exergy destruction and exergy efficiency of oil nanofluid (Cu +oil) were greater than the oil nanofluid (ZrO2 +oil) and oil. The exergy inflow, exergy destruction, and exergy efficiency for the two type of oil nanofluid increased with increasing of nanoparticles concentration. [ABSTRACT FROM AUTHOR]