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This paper presents an anisotropic damage model to deal with the fragmentation induced by impact loadings on glass samples. As small-scale (i.e. sub-element) damage is described as well as cracks extending above the element scale, an approach referred to as “meso-damage” is developed. The latter, which is based on the knowledge of random distributions of initiation sites, predicts different regimes such as single or multiple fragmentation. The experimental opening crack pattern obtained in edge-on-impact test is reproduced numerically. [ABSTRACT FROM AUTHOR]