1. Infertility in a patient with abnormal spermatogenesis and in utero DES exposure.
- Author
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Hembree WC, Nagler HM, Fang JS, Myles EL, and Jagiello GM
- Subjects
- Adult, Chromosome Mapping, Female, Humans, Infertility, Male physiopathology, Male, Oligospermia pathology, Pregnancy, Testis pathology, Diethylstilbestrol adverse effects, Infertility, Male pathology, Meiosis drug effects, Prenatal Exposure Delayed Effects, Spermatocytes pathology, Spermatogenesis drug effects
- Abstract
A young azoospermic patient is described whose spermatogenesis reflected an abnormality of meiosis. A diagnosis of asynapsis of chromosomes during early spermatogenesis was made by cytogenetic examination of a testicular biopsy. Standard histologic examination gave no indication of this abnormality. An incidental history of intrauterine diethylstilbesterol (DES) exposure of the patient was elicited. Attention is called to the dearth of cytogenetic studies of spermatogenesis in DES-treated male progeny and the usefulness in general of meiotic cytogenetic studies for obtaining accurate diagnoses in human infertility.
- Published
- 1988