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Your search keyword '"Lyttleton, Oliver"' showing total 3 results
Start Over Author "Lyttleton, Oliver" Journal international journal of epidemiology
3 results on '"Lyttleton, Oliver"'

1. Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

Author

Sharp, Gemma C, Lawlor, Debbie A, Richmond, Rebecca C, Fraser, Abigail, Simpkin, Andrew, Suderman, Matthew, Shihab, Hashem A, Lyttleton, Oliver, McArdle, Wendy, Ring, Susan M, Gaunt, Tom R, Davey Smith, George, and Relton, Caroline L

Subjects
Male, causality, longitudinal, Adolescent, Epigenetic, Maternal Nutritional Physiological Phenomena, ALSPAC, DNA Methylation, epigenome-wide association study, Weight Gain, United Kingdom, Body Mass Index, undernutrition, Overnutrition, Thinness, Pregnancy, ARIES, overweight, Humans, Female, Longitudinal Studies, Obesity, Child, Genome-Wide Association Study, Adiposity
Abstract

Background: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. Methods: We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA methylation in relation to maternal and offspring adiposity in 1018 participants. Results: Compared with neonatal offspring of normal weight mothers, 28 and 1621 CpG sites were differentially methylated in offspring of obese and underweight mothers, respectively [false discovert rate (FDR)-corrected P-value

Published
2015

3. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)

Author

Relton, Caroline L, primary, Gaunt, Tom, additional, McArdle, Wendy, additional, Ho, Karen, additional, Duggirala, Aparna, additional, Shihab, Hashem, additional, Woodward, Geoff, additional, Lyttleton, Oliver, additional, Evans, David M, additional, Reik, Wolf, additional, Paul, Yu-Lee, additional, Ficz, Gabriella, additional, Ozanne, Susan E, additional, Wipat, Anil, additional, Flanagan, Keith, additional, Lister, Allyson, additional, Heijmans, Bastiaan T, additional, Ring, Susan M, additional, and Davey Smith, George, additional

Published
2015
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