1. Prenatal phthalate exposure and birth size: a systematic review and meta-analysis.
- Author
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Yu, Yuanyuan, Jia, Yaning, Liu, Qisijing, Zhao, Lei, Lin, Huishu, Liu, Ziquan, Fang, Tao, Jiang, Wenbing, Cui, Huanhuan, Hou, Shike, and Guo, Liqiong
- Subjects
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MEDICAL information storage & retrieval systems , *STATISTICAL correlation , *EFFECT sizes (Statistics) , *PRENATAL exposure delayed effects , *MATERNAL exposure , *SMALL for gestational age , *RESEARCH funding , *META-analysis , *CEPHALOMETRY , *DECISION making in clinical medicine , *DESCRIPTIVE statistics , *SYSTEMATIC reviews , *MEDLINE , *WAIST circumference , *PLASTICIZERS , *BIRTH weight , *PREGNANCY complications , *ONLINE information services , *CONFIDENCE intervals , *DATA analysis software , *REGRESSION analysis , *PREGNANCY - Abstract
Phthalates are common endocrine disruptors. The placental barrier can be crossed by phthalates and may have a negative impact on the health of the fetus. However, the association between prenatal exposure to phthalates and birth size is still debatable. Here, we performed this meta-analysis to assess the relationship between prenatal phthalates exposure and birth size. Eighteen studies were finally included by searching PubMed, Embase, Scopus, Ovid, and Web of Science databases and standardized regression coefficients and standard errors were used to pool effect size. Our results showed that prenatal exposure to MMP (=-0.04, 95%CI: −0.08, −0.01) and MEP (=-0.01, 95%CI: −0.01, −0.002) was significantly associated with birth weight. However, no significant associations were identified for phthalate exposure with birth length, head circumference and chest circumference. Because the limiting of studies, more high-quality case–control studies or cohort studies are urgently needed to draw the best conclusions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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