Search

Background. Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. Methods. The China H-type Hypertension Registration (an observational, noninterventional, and real-world study) was conducted from March 01, 2018, to August 31, 2018, in 16 communities in Wuyuan of China. The TyG index was calculated from fasting triglycerides (mg/dL) and fasting glucose (mg/dL)/2. Hyperuricemia was categorized by uric acid concentration ≥420 μmol/L (7 mg/dL). Results. Overall average TyG index of 13,060 adults with hypertension was 8.87; age was 63.81 years. The TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β = 38.03; 95% CI: 34.55 to 41.51). Coincidentally, logistic analyses also demonstrated the TyG index had a positive correlation with hyperuricemia (OR = 2.04; 95% CI: 1.87 to 2.24). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Compared with subjects in the lowest quartile (7.13 to 8.44) of the TyG index, subjects in the 2nd–4th quartiles had 1.25 (95% CI: 1.10 to 1.41), 1.63 (95% CI: 1.43 to 1.86), and 2.79 (95% CI: 2.41 to 3.24) times greater incident risk of developing hyperuricemia. The TyG index had significant correlations between male patients and hyperuricemia (OR = 2.01) by subgroup analysis. Conclusion. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. This trial was registered at clinicaltrials.gov as ChiCTR1800017274.

Background. The association between triglyceride-rich lipoprotein cholesterol (TRL-C) and diabetes mellitus (DM) remains unclear because of limited research and data. The aim of this study was to explore the independent association between TRL-C and DM in hypertensive patients and to examine whether a healthy lifestyle would have an impact on this relationship. Methods. In this study, data from 13,721 hypertensive patients who were not treated with lipid-lowering drugs were analyzed. TRL-C was calculated from total cholesterol (TC) minus [LDL cholesterol + HDL cholesterol]. DM was defined as fasting plasma glucose of ≥7.0 mmol/L and/or self-reported history of hypoglycemic drug use. Results. After adjusting for potential confounding factors, the TRL-C was significantly positively associated with elevated DM (odds ratio (OR): 1.73 and 95% confidence interval (CI): 1.54–1.94). In subgroup analysis, a healthy lifestyle (HL) failed to modify the positive association between TRL-C and DM (HL: OR 1.93, 95%CI 1.58–2.36; non-HL: OR 1.72, 95%CI 1.50–1.98; P for interaction = 0.38). Conclusion. The results showed a positive association between TRL-C and DM in hypertensive patients. A healthy lifestyle failed to diminish the relationship between TRL-C and DM. The novel findings indicate that TRL-C might be a reliable marker of DM and may provide a new strategy for the prevention and treatment of DM.

Background. Evidence regarding the nonlinear relationship between serum uric acid (SUA) and blood lipids in Chinese population with hypertension is limited. Therefore, the present study aimed to investigate whether there is a nonlinear association between SUA and lipids in Chinese hypertensive population with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2. Methods. A total of 13,355 hypertensive participants with eGFR ≥30 ml/min/1.73 m2 were selected from the Chinese Hypertension Registry Study. Multivariate linear regression was used to examine the linear relationship between SUA and lipids. Smooth curve fitting (penalized spline method) and threshold saturation effects were used to analyze the nonlinear association between SUA and lipids. Results. In the fully adjusted model, the results showed a positive correlation between SUA and TG (β = 0.15; 95% CI: 0.14, 0.16) and LDL-C (β = 0.06; 95% CI: 0.05, 0.07), respectively. However, the relationship between SUA and HDL-C was nonlinear. The inflection point of SUA was 7.24 mg/dL. On the left side of the inflection point (