1. Is psoriasis a pre-atherosclerotic disease? Increased insulin resistance and impaired endothelial function in patients with psoriasis
- Author
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Bunyamin Yavuz, Kursad Dal, Metin Kucukazman, Ayse Serap Karadag, Naim Ata, Ahmet Arif Yalcin, Onur Sinan Deveci, Derun Taner Ertugrul, and Kadir Okhan Akin
- Subjects
medicine.medical_specialty ,Endothelium ,business.industry ,Insulin ,medicine.medical_treatment ,Arthritis ,Dermatology ,medicine.disease ,Gastroenterology ,Endocrinology ,medicine.anatomical_structure ,Insulin resistance ,Psoriasis ,medicine.artery ,Internal medicine ,medicine ,In patient ,Brachial artery ,business ,Homeostasis - Abstract
Background Several studies have shown an association between psoriasis and atherosclerotic risk factors. In this study, we aimed to evaluate endothelial function by flow-mediated dilation (FMD) and insulin resistance by Homeostasis model assessment-insulin resistance (HOMA-IR). Methods We examined 75 consecutive psoriasis patients and 50 healthy controls. All subjects underwent transthoracic echocardiography and brachial artery imaging for detecting FMD. Fasting blood samples were drawn from all subjects for measuring insulin, C-peptide, fasting blood glucose. HOMA-IR was calculated. Results Baseline characteristics of both groups were similar. Twenty-four psoriatic patients had arthritis. Insulin [9.3 (4.0–208.1) vs. 8.2 (2.3–16.5) mcIU/ml, P = 0.016] and C-peptide [2.5 (0.9–20.0) vs. 2.0 (0.9–3.7) ng/ml, P = 0.009] levels were significantly higher in patients with psoriasis than in controls. HOMA-IR [2.1 (0.8–68.9) vs. 1.8 (0.6–8.6), P = 0.036] was significantly higher in patients with psoriasis than in controls. FMD was reduced in patients with psoriasis compared with healthy controls (5.6 ± 1.9% vs. 10.9 ± 1.9%, P
- Published
- 2010
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