18 results on '"Archana, Singal"'
Search Results
2. Mucocutaneous leishmaniasis caused byLeishmania donovaniinfection in an Indian man
- Author
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Archana Singal, Amit Kumar Dhawan, Sonal Sharma, Deepika Pandhi, and Deepashree Daulatabad
- Subjects
Leishmaniasis, Mucocutaneous ,Male ,biology ,business.industry ,Sodium stibogluconate ,Leishmania donovani ,India ,Leishmaniasis ,Dermatology ,Middle Aged ,biology.organism_classification ,medicine.disease ,Leishmania ,Cutaneous leishmaniasis ,Immunology ,Humans ,Medicine ,Leishmania major ,Leprosy ,business ,Mycobacterium leprae ,medicine.drug - Abstract
Background Leishmaniasis is a protozoal disease caused by species of Leishmania. Mucocutaneous leishmaniasis (MCL) involves the skin and mucosa. India is endemic for species such as Leishmania donovani and Leishmania major, which are responsible for visceral and cutaneous leishmaniasis, respectively. Although MCL has been reported from India previously, the implicated pathogen was identified as L. donovani in only one case. Case report A 55-year-old man presented with a nasal ulcer of four years' duration. He had been treated for borderline lepromatous (BL) leprosy 25 years earlier. Differential diagnoses of MCL, lupus vulgaris, and subcutaneous mycosis were considered. Leishman–Donovan bodies were seen on tissue imprints, and histopathology showed epidermal thinning with loss of appendages and dense pandermal infiltrate. Polymerase chain reaction was positive for L. donovani-specific DNA amplification. A diagnosis of MCL with treated BL leprosy was made. The patient was treated with sodium stibogluconate and achieved complete healing of the ulcer. Conclusions The coexistence of manifestations of disease from opposite ends of the spectrum (a hyperergic form of leishmaniasis with an anergic form of leprosy) is difficult to explain. However, the development of MCL after the cure of BL leprosy may reflect the loss of the inhibitory effect of Mycobacterium leprae antigen on interferon-γ production, and delayed persistence and the gradual clearance of the antigen from the body may account for the 20-year time lag. Further research centered on the immunological interactions between leishmaniasis and leprosy is warranted, particularly with respect to different Leishmania species.
- Published
- 2014
3. Subungual fibro-osseous pseudotumour of the digit: a rare occurrence
- Author
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Archana Singal, Priyanka Gogoi, Shuchi Bhatt, and Deepika Pandhi
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Dermatology ,Fibro-osseous pseudotumour ,Numerical digit ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Dermis ,030220 oncology & carcinogenesis ,Medicine ,business - Published
- 2016
4. Comparative efficacy of tacrolimus 0.1% ointment and clobetasol propionate 0.05% ointment in oral lichen planus: a randomized double-blind trial
- Author
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Archana Singal and Sidharth Sonthalia
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Dermatology ,medicine.disease ,Tacrolimus ,law.invention ,stomatognathic diseases ,medicine.anatomical_structure ,Randomized controlled trial ,law ,Etiology ,Medicine ,Oral lichen planus ,Oral mucosa ,Clobetasol propionate ,business ,Adverse effect ,Topical steroid ,medicine.drug - Abstract
Oral lichen planus (OLP) is a common disease of the oral mucosa with worldwide distribution and overall prevalence of 0.5-2.2%. Its etiology remains unclear, although the role of autoimmunity is supported by its association with other autoimmune diseases and the presence of auto-cytotoxic T cell clones in the lesions. Although many options for treating symptomatic OLP are available, no therapy is curative. This trial compared treatments with topical tacrolimus 0.1% ointment and topical clobetasol propionate 0.05% ointment. Forty patients with histologically proven symptomatic OLP were divided into two groups of 20 to receive clobetasol propionate (0.05%) ointment or tacrolimus (0.1%) ointment for eight weeks. Follow-up for all patients included three visits during the treatment course and one post-treatment visit. At each visit, objective improvement in the lesions was assessed by two independent investigators. The primary outcome measure was defined as the percentage of patients attaining complete response at eight weeks. Secondary outcome measures were the percentages of patients attaining complete or partial response at 8 and 12 weeks. Patient-observed improvement was evaluated at each visit. Demographic parameters and pretreatment disease characteristics were comparable between the groups. The mean net clinical score (NCS) declined progressively from baseline at each follow-up visit in both groups. In the clobetasol group, the mean NCS declined from 8.00 ± 2.65 at baseline to 2.00 ± 1.49 at 12 weeks. In the tacrolimus group, the mean NCS declined from 7.78 ± 3.25 at baseline to 1.31 ± 1.06 at 12 weeks. At each visit, the decline in mean NCS from baseline was statistically significant (P 0.05). No severe adverse events were reported. Tacrolimus 0.1% ointment is an effective alternative to topical steroid and may be considered as a first-line therapy in OLP.
- Published
- 2012
5. Comparison of the radiometric BACTEC 460 TB culture system and Löwenstein–Jensen medium for the isolation of mycobacteria in cutaneous tuberculosis and their drug susceptibility pattern
- Author
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Puneet Aggarwal, Archana Singal, Sambit Nath Bhattacharya, and Kiran Mishra
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Adult ,Male ,Tuberculosis ,Adolescent ,Antitubercular Agents ,Microbial Sensitivity Tests ,Dermatology ,Drug resistance ,Sensitivity and Specificity ,Microbiology ,Cohort Studies ,Mycobacterium tuberculosis ,Humans ,Medicine ,Child ,Tuberculosis, Cutaneous ,Ethambutol ,Aged ,Probability ,Bacteriological Techniques ,Chi-Square Distribution ,biology ,business.industry ,Biopsy, Needle ,Isoniazid ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Culture Media ,Löwenstein–Jensen medium ,Streptomycin ,Child, Preschool ,Female ,business ,Rifampicin ,medicine.drug - Abstract
Background Mycobacterial isolation from cutaneous tuberculosis on Lowenstein–Jensen (L–J) medium has been reported to be low. The radiometric BACTEC 460 TB culture system (BACTEC system) has shown better isolation rates in pulmonary tuberculosis. There has been a progressive increase in the prevalence of multidrug resistance in pulmonary tuberculosis, but similar studies are lacking for cutaneous tuberculosis. Therefore, this study was undertaken to compare mycobacterial isolation on conventional L–J medium vs. the BACTEC system, and to determine the prevalence of multidrug resistance in cutaneous tuberculosis. Methods Thirty-five untreated, clinically diagnosed, and histopathologically documented patients with cutaneous tuberculosis constituted the study material. Lesional skin biopsy specimens were cultured on both L–J medium and the BACTEC system. The isolates obtained were identified and subjected to sensitivity to rifampicin, isoniazid, ethambutol, and streptomycin using the BACTEC system. Results Twenty-six mycobacterial isolates were recovered from 35 patients. Nine isolates (25.7%) grew on L–J medium after a mean period of 31.5 days, and 22 (62.8%) on the BACTEC system in 17.3 days. All of the isolates were identified as Mycobacterium tuberculosis. Drug susceptibility testing demonstrated 12 isolates to be resistant, seven multidrug resistant. Discussion The BACTEC system demonstrated an improved mycobacterial isolation rate and substantially reduced detection time when compared with L–J medium. The combined isolation rate on both media was 74.3% (26/35), greater than that of either used separately. Drug resistance was observed in 46.2% of isolates. Conclusion Radiometric liquid culture medium together with conventional L–J medium may be recommended in practice to enable the institution of appropriate antituberculous therapy modifications in drug-resistant cases of cutaneous tuberculosis.
- Published
- 2008
6. Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence
- Author
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Deepika Pandhi, Archana Singal, Sarla Aggarwal, Sambit Nath Bhattacharya, Shukla Das, and Kiran Mishra
- Subjects
Antifungal ,medicine.medical_specialty ,Medical treatment ,biology ,Itraconazole ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,Cryotherapy ,Dermatology ,biology.organism_classification ,Exophiala ,medicine ,Terbinafine ,business ,Fluconazole ,Exophiala spinifera ,medicine.drug - Abstract
A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for Exophiala spinifera, in vitro sensitivity testing is recommended before medical treatment. This article reviews, in brief, all cases documented so far in the English literature.
- Published
- 2007
7. Lichen scrofulosorum and endometrial tuberculosis: a novel association
- Author
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Deepika Pandhi and Archana Singal
- Subjects
Infertility ,Adult ,medicine.medical_specialty ,Pathology ,Tuberculosis ,Lichenoid Eruptions ,Antitubercular Agents ,Dermatology ,Asymptomatic ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Humans ,Tuberculosis, Cutaneous ,Lichen scrofulosorum ,Uterine Diseases ,medicine.diagnostic_test ,business.industry ,Female infertility ,Mycobacterium tuberculosis ,medicine.disease ,030220 oncology & carcinogenesis ,Lichenoid eruption ,Skin biopsy ,Female ,medicine.symptom ,business ,Infertility, Female ,Endometrial biopsy - Abstract
Background Lichen scrofulosorum (LS) is a rare tuberculid with an underlying systemic focus of tuberculosis (Tb) detected in majority of cases. The associated Tb foci reported in literature include pulmonary, lymph node, intracranial, abdominal, and cutaneous Tb. We report two women who presented with LS and infertility due to endometrial Tb; an association hitherto undescribed. Case report Case 1: A 24-year-old woman presented with asymptomatic grouped papules of LS over the trunk associated with secondary infertility. Endometrial biopsy was suggestive of endometrial Tb, and PCR was positive for M. tuberculosis. The skin lesions resolved after 3 months of anti-tubercular therapy (ATT). Case 2: A 27-year-old woman presented with erythematous, grouped, perifollicular papules over the trunk 5 weeks after starting ATT for endometrial Tb that was diagnosed during work up for primary infertility. A skin biopsy confirmed the diagnosis of LS, and lesions resolved with continuation of ATT for 10 weeks. Conclusion LS can mimic several dermatologic diseases, and a high index of suspicion is required for the diagnosis and initiation of investigations to detect the underlying Tb focus. A good obstetric history in females will aid in early diagnosis and initiation of appropriate therapy.
- Published
- 2015
8. Clinical and serological efficacy of topical calcineurin inhibitors in oral lichen planus: a prospective randomized controlled trial
- Author
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Suman Bala Sharma, Archana Singal, and Suruchi Vohra
- Subjects
Adult ,Male ,medicine.medical_specialty ,Administration, Topical ,Calcineurin Inhibitors ,Dermatology ,Gastroenterology ,Risk Assessment ,Severity of Illness Index ,Drug Administration Schedule ,Tacrolimus ,Serology ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Pimecrolimus ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Medicine ,Humans ,Single-Blind Method ,Prospective Studies ,Analysis of Variance ,Chi-Square Distribution ,Dose-Response Relationship, Drug ,business.industry ,Interleukin-6 ,Interleukin-8 ,Interleukin ,030206 dentistry ,Middle Aged ,medicine.disease ,Calcineurin ,Treatment Outcome ,Tolerability ,Oral lichen planus ,Female ,business ,medicine.drug ,Follow-Up Studies ,Lichen Planus, Oral - Abstract
Oral lichen planus (OLP) is a T-cell-mediated disease characterized by immune-mediated basal cell degeneration releasing interleukins (ILs) such as IL-6 and IL-8 into the circulation. Their serum levels reportedly reflect disease activity. Although many therapeutic options are available, none are curative. We compared the efficacy of tacrolimus 0.1% ointment and pimecrolimus 1% cream in OLP and correlated with serum IL-6 and IL-8 levels before and after treatment. Forty patients with symptomatic OLP were randomized into two groups, to receive either topical tacrolimus 0.1% ointment or pimecrolimus 1% cream (twice daily for 8 weeks). Patients were assessed at 2, 4, 8, and 12 weeks. At each visit, objective improvement in the net clinical score (NCS), drug tolerability, and side effects were evaluated. Serum IL-6 and IL-8 levels were measured at baseline and at eight weeks. Baseline characteristics were comparable between the groups. The mean NCS declined from 10.9 ± 4.5 and 9.9 ± 4.6 at baseline to 5.4 ± 3.5 and 5.3 ± 4.2 at 12 weeks for tacrolimus and pimecrolimus group, respectively. At each visit, in both groups, the decline in mean NCS from baseline was statistically significant (P
- Published
- 2014
9. Lichen scrofulosorum: yet another disease manifesting the Koebner phenomenon?
- Author
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Neelam Wadhwa, Archana Singal, and Deepika Pandhi
- Subjects
medicine.medical_specialty ,business.industry ,030231 tropical medicine ,Koebner phenomenon ,Dermatology ,Disease ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,business ,Yet another ,Lichen scrofulosorum - Published
- 2015
10. Utility of Mantoux test in the diagnosis of doubtful cases of cutaneous tuberculosis
- Author
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Prashant Verma and Archana Singal
- Subjects
Male ,medicine.medical_specialty ,Cutaneous tuberculosis ,medicine.diagnostic_test ,business.industry ,Tuberculin Test ,Dermatology ,Mantoux test ,medicine ,Humans ,Female ,Tuberculin test ,business ,Tuberculosis, Cutaneous - Published
- 2013
11. Comparative efficacy of tacrolimus 0.1% ointment and clobetasol propionate 0.05% ointment in oral lichen planus: a randomized double-blind trial
- Author
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Sidharth, Sonthalia and Archana, Singal
- Subjects
Adult ,Male ,Ointments ,Clobetasol ,Double-Blind Method ,Humans ,Female ,Glucocorticoids ,Immunosuppressive Agents ,Tacrolimus ,Lichen Planus, Oral - Abstract
Oral lichen planus (OLP) is a common disease of the oral mucosa with worldwide distribution and overall prevalence of 0.5-2.2%. Its etiology remains unclear, although the role of autoimmunity is supported by its association with other autoimmune diseases and the presence of auto-cytotoxic T cell clones in the lesions. Although many options for treating symptomatic OLP are available, no therapy is curative. This trial compared treatments with topical tacrolimus 0.1% ointment and topical clobetasol propionate 0.05% ointment. Forty patients with histologically proven symptomatic OLP were divided into two groups of 20 to receive clobetasol propionate (0.05%) ointment or tacrolimus (0.1%) ointment for eight weeks. Follow-up for all patients included three visits during the treatment course and one post-treatment visit. At each visit, objective improvement in the lesions was assessed by two independent investigators. The primary outcome measure was defined as the percentage of patients attaining complete response at eight weeks. Secondary outcome measures were the percentages of patients attaining complete or partial response at 8 and 12 weeks. Patient-observed improvement was evaluated at each visit. Demographic parameters and pretreatment disease characteristics were comparable between the groups. The mean net clinical score (NCS) declined progressively from baseline at each follow-up visit in both groups. In the clobetasol group, the mean NCS declined from 8.00 ± 2.65 at baseline to 2.00 ± 1.49 at 12 weeks. In the tacrolimus group, the mean NCS declined from 7.78 ± 3.25 at baseline to 1.31 ± 1.06 at 12 weeks. At each visit, the decline in mean NCS from baseline was statistically significant (P0.05) in both groups. Complete response rates of 40% and 70%, respectively, were achieved in the clobetasol and tacrolimus groups (P = 0.057). The percentages of patients reporting "good" or "very good" treatment responses at week 8 were 74% in the clobetasol group and 100% in the tacrolimus group (P0.05). No severe adverse events were reported. Tacrolimus 0.1% ointment is an effective alternative to topical steroid and may be considered as a first-line therapy in OLP.
- Published
- 2012
12. Erythema gyratum repens-like eruption occuring in resolving psoriasis during methotrexate therapy
- Author
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Archana Singal, Sidharth Sonthalia, and Deepika Pandhi
- Subjects
medicine.medical_specialty ,Erythema gyratum repens ,business.industry ,Histamine Antagonists ,Dermatology ,Middle Aged ,medicine.disease ,Methotrexate ,Erythema ,Psoriasis ,Medicine ,Humans ,Female ,Dermatologic Agents ,Drug Eruptions ,medicine.symptom ,business ,medicine.drug - Published
- 2010
13. Comparison of culture systems for the isolation of mycobacteria in cutaneous tuberculosis
- Author
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Archana Singal and Puneet Aggarwal
- Subjects
Bacteriological Techniques ,Cutaneous tuberculosis ,Isolation (health care) ,business.industry ,Immunology ,Medicine ,Humans ,Dermatology ,Mycobacterium tuberculosis ,business ,Tuberculosis, Cutaneous ,Microbiology - Published
- 2009
14. Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence
- Author
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Archana, Singal, Deepika, Pandhi, Sambit N, Bhattacharya, Shukla, Das, Sarla, Aggarwal, and Kiran, Mishra
- Subjects
Male ,Antifungal Agents ,Exophiala ,Dermatomycoses ,Humans ,Microbial Sensitivity Tests ,Treatment Failure ,Child ,Immunocompetence ,Skin - Abstract
A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for Exophiala spinifera, in vitro sensitivity testing is recommended before medical treatment. This article reviews, in brief, all cases documented so far in the English literature.
- Published
- 2008
15. Lichen scrofulosorum: a prospective study of 39 patients
- Author
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Archana Singal and Sambit Nath Bhattacharya
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Tuberculosis ,Adolescent ,Antitubercular Agents ,Dermatology ,Tuberculosis, Lymph Node ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Child ,Tuberculosis, Cutaneous ,Tuberculosis, Pulmonary ,Lichen scrofulosorum ,Brain Diseases ,medicine.diagnostic_test ,business.industry ,Vaccination ,Mantoux test ,medicine.disease ,Occult ,Erythrocyte sedimentation rate ,Child, Preschool ,Etiology ,BCG Vaccine ,Female ,business ,BCG vaccine ,Follow-Up Studies - Abstract
Background Lichen scrofulosorum is considered a rare form of cutaneous tuberculosis. Current information is based on case reports and case series with a small number of patients. Methods Thirty-nine patients with Lichen scrofulosorum were followed during the period January 1996 to December 2002. Clinical details (age, sex, duration of disease, associated tubercular lesions, extent and distribution of skin lesions), laboratory parameters (hemoglobin, total leucocytic counts, erythrocyte sedimentation rate, Mantoux test, presence of BCG scar), and response to antitubercular treatment were recorded and analyzed. Results 7.6% patients of all (511) patients with cutaneous tuberculosis had LS. 22 (56.4%) were males and 32 (84%) were below 15 years of age. Twenty-eight (72%) had an associated focus of tuberculosis elsewhere in the body; 13 (33%) had tubercular lymphadenopathy, while 11 (28%), three (8%) and six (15%) had pulmonary tuberculosis, intracranial tuberculosis and other forms of cutaneous tuberculosis, respectively. Six (15%) had tubercular focus at multiple sites. Eleven (28%) had no other identifiable focus of tuberculosis. Twenty-eight (72%) had evidence of receiving BCG vaccination. Trunk was the commonest (100%) affected site. The two groups with and without associated tubercular focus were not different with respect to age, sex, duration of disease, hemoglobin, total leukocyte count, erythrocyte sedimentation rate, Mantoux test positivity, and presence of BCG scar. Mycobacteria tuberculosis could not be detected either on acid fast bacilli (AFB) staining or on culture from biopsies of LS lesions. All patients (including those without evidence of tubercular focus) responded to antitubercular treatment, signifying an underlying occult tubercular focus as etiology. Conclusions Lichen scrofulosorum is an uncommon but not rare cutaneous manifestation of tuberculosis. A high index of suspicion and awareness is required for diagnosis. Systemic tuberculosis is often associated with LS and a prior BCG inoculation does not protect against development of LS. Response to antitubercular treatment is good irrespective of the presence or absence of associated tubercular focus.
- Published
- 2005
16. Pityriasis rosea unilateralis with atypical morphology
- Author
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Deepika Pandhi, Archana Singal, and Namrata Chhabra
- Subjects
medicine.medical_specialty ,business.industry ,Pityriasis rosea ,Medicine ,Morphology (biology) ,Dermatology ,business ,medicine.disease - Published
- 2012
17. Mondor's phlebitis of penis following recurrent candidal balanoposthitis
- Author
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Subhav Kumar Agrawal, Archana Singal, and Deepika Pandhi
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Balanoposthitis ,medicine ,MEDLINE ,Dermatology ,business ,medicine.disease ,Penis - Published
- 2005
18. Familial mucosal lichen planus in three successive generations
- Author
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Archana Singal
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Medicine ,Dermatology ,Lichen ,business - Published
- 2005
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