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Based on the isothermal fatigue and creep damage, a life prediction approach under multiaxial thermo-mechanical loading was proposed in this investigation. In the proposed method, the multiaxial thermo-mechanical fatigue damage during one cycle period was divided into the isothermal fatigue damage and the creep damage. In order to evaluate conservatively, the isothermal fatigue damage during one cycle period was calculated by using multiaxial fatigue damage model at the maximum temperature during the whole period, and the creep damage during one cycle period was calculated by accumulating the creep damage of all portions originated from the divided time history for the axial load component and temperature history. The life prediction results by the proposed model showed a good agreement with experimental data for nickel-base alloy GH4169 and cobalt-base Haynes188 under axial-torsional thermo-mechanical loading. [ABSTRACT FROM AUTHOR]