1. The anti-inflammatory effect of cherry blossom extract (Prunus yedoensis) used in soothing skincare product
- Author
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Z. Y. Zhong, D. K. Zhang, Wei Lai, Yong Zhang, Hua-Bin Li, M. Chang, and L. Guan
- Subjects
Adult ,Male ,Aging ,medicine.medical_specialty ,Prunus × yedoensis ,Erythema ,Adolescent ,medicine.drug_class ,Anti-Inflammatory Agents ,Pharmaceutical Science ,Dermatology ,Flowers ,Placebo ,Anti-inflammatory ,Cell Line ,Ingredient ,Mice ,Young Adult ,Colloid and Surface Chemistry ,In vivo ,Drug Discovery ,medicine ,Animals ,Humans ,Nitrites ,Aged ,Inflammation ,Traditional medicine ,biology ,business.industry ,Plant Extracts ,Macrophages ,Sodium lauryl sulphate ,Patch test ,Middle Aged ,Patch Tests ,biology.organism_classification ,Skin Care ,Surgery ,Chemistry (miscellaneous) ,Female ,Prunus ,medicine.symptom ,business - Abstract
SynopsisObjective Previous investigations suggested that cherry blossoms could provide valuable bioactive materials. However, few observations regarding the anti-inflammatory effect of cherry blossoms were reported. This study was to explore the anti-inflammatory effect of cherry blossom extract (CBE), which was used as a soothing ingredient in skincare product. Methods In vitro study, the anti-inflammatory effect of CBE on the nitric oxide (NO) inhibition assay in lipopolysaccharide (LPS)-treated RAW 264.7 cells was investigated. In vivo study, 40 volunteers were included in a randomized, single-blinded, placebo-controlled trial. 24-hour-occlusive test chambers were applied on the flexor side of the forearm with 3% sodium lauryl sulphate (SLS). Subsequently, the test areas were treated on 9 subsequent days with a cream containing 3% CBE or a placebo. Evaluation included a visual score and determination of erythema value (E value). Results In vitro study, 2% CBE reduced NO production by 31.83% compared to the placebo. In the SLS irritant patch test, the visual score and erythema value of CBE were lower than that of the placebo on D5 and D9. Conclusion Cherry blossom extract shows good anti-inflammatory effect in vitro and in vivo and represents a promising functional ingredient in soothing skincare product by reducing skin inflammation. more...
- Published
- 2014