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Modern graphics processing units (GPUs) have been at the leading edge of increasing parallelism over the last 10 years. This fact has encouraged the use of GPUs in a broader range of applications, where developers are required to lever age this technology with new programming models which ease the task of writing programs to run efficiently on GPUs. In this paper, we discuss the main guidelines to assist the developer when porting sequential scientific code on modern GPUs. These guidelines were carried out by porting theL-BFGS, the (Limited memory-) BFGS algorithm for large scale optimization, available as Harwell routine VA15. The specific interest in theL-BFGSalgorithm arises from the fact that this is the computational module with the longest running time of a Oceanographic Data Assimilation application software, on which some of the authors are working. [ABSTRACT FROM AUTHOR]