Search

Bacillus Calmette-Guerin (BCG) is a vaccine derived from attenuated strains of Mycobacterium bovis. Mycobacterium bovis BCG-based therapy is considered an effective alternative for bladder carcinoma in situ when exclusive transurethral resection is inadequate. Among the complications associated with therapy, there are few reports in the literature on reactive arthritis. We report the case of a 56-year-old woman who develops predominantly peripheral spondyloarthritis, following instillation of BCG, as preventive treatment of relapse onset high-grade urothelial carcinoma after surgical resection.

Behcet's disease, is an inflammatory disease of unknown etiology with multisystem involvement and chronic course. In addition to the triad (recurrent oral and genital ulcers, and uveitis), it may exhibit involvement of other organs, but it is a rare hematologic commitment. Behcet's disease association with myelodysplastic processes, although uncommon, has been previously described. We report the case of a patient with Behcet's disease who developed thrombocytopenia and monocytosis. Trisomy 8 was found in karyotypic ana­lysis and findings of myelodysplastic/myeloproliferative disease in the bone marrow. We discuss the relationship between trisomy 8, myelodysplastic syndrome and Behcet's disease.