1. Multimodality imaging for real-time image-guided left ventricular lead placement during cardiac resynchronization therapy implantations
- Author
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Wouter M. van Everdingen, Odette A.E. Salden, Birgitta K. Velthuis, Maarten J. Cramer, Hans T. van den Broek, Mathias Meine, Frebus J. van Slochteren, Pieter A. Doevendans, Anton E. Tuinenburg, Paul Leufkens, and Firdaus A. A. Mohamed Hoesein
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Left ,Myocardial Ischemia ,Myocardial Ischemia/complications ,030204 cardiovascular system & hematology ,Heart Ventricles/diagnostic imaging ,Magnetic Resonance Imaging, Interventional ,Radiography, Interventional ,Multimodal Imaging ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,Cardiac Resynchronization Therapy ,0302 clinical medicine ,Computer-Assisted ,Interventional/methods ,Fluoroscopy ,Ventricular Function ,Prospective Studies ,Cardiac imaging ,Ejection fraction ,medicine.diagnostic_test ,Ventricular Remodeling ,Radiographic Image Interpretation ,Equipment Design ,Middle Aged ,Magnetic Resonance Imaging ,Treatment Outcome ,Cine ,Radiology Nuclear Medicine and imaging ,Cardiology ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Cardiomyopathies ,Lead Placement ,Cardiology and Cardiovascular Medicine ,Multimodal Imaging/methods ,medicine.medical_specialty ,Heart Ventricles ,Cardiac resynchronization therapy ,Magnetic Resonance Imaging, Cine ,Magnetic Resonance Imaging, Interventional/methods ,Targeted lead placement ,Multimodality imaging ,03 medical and health sciences ,Cardiomyopathies/diagnostic imaging ,Radiography, Interventional/methods ,Predictive Value of Tests ,Internal medicine ,Multidetector Computed Tomography ,medicine ,Journal Article ,Image fusion ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac Resynchronization Therapy Devices ,Ventricular remodeling ,Aged ,Original Paper ,Ischemic cardiomyopathy ,business.industry ,Image-guided interventions ,Recovery of Function ,medicine.disease ,Radiography ,Feasibility Studies ,business - Abstract
This study was performed to evaluate the feasibility of intra-procedural visualization of optimal pacing sites and image-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT). In fifteen patients (10 males, 68 ± 11 years, 7 with ischemic cardiomyopathy and ejection fraction of 26 ± 5%), optimal pacing sites were identified pre-procedurally using cardiac imaging. Cardiac magnetic resonance (CMR) derived scar and dyssynchrony maps were created for all patients. In six patients the anatomy of the left phrenic nerve (LPN) and coronary sinus ostium was assessed via a computed tomography (CT) scan. By overlaying the CMR and CT dataset onto live fluoroscopy, aforementioned structures were visualized during LV lead implantation. In the first nine patients, the platform was tested, yet, no real-time image-guidance was implemented. In the last six patients real-time image-guided LV lead placement was successfully executed. CRT implant and fluoroscopy times were similar to previous procedures and all leads were placed close to the target area but away from scarred myocardium and the LPN. Patients that received real-time image-guided LV lead implantation were paced closer to the target area compared to patients that did not receive real-time image-guidance (8 mm [IQR 0-22] vs 26 mm [IQR 17-46], p = 0.04), and displayed marked LV reverse remodeling at 6 months follow up with a mean LVESV change of -30 ± 10% and a mean LVEF improvement of 15 ± 5%. Real-time image-guided LV lead implantation is feasible and may prove useful for achieving the optimal LV lead position.
- Published
- 2019