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Your search keyword '"Mulè, M"' showing total 3 results
Start Over Author "Mulè, M" Journal international journal of cardiology
3 results on '"Mulè, M"'

1. Prognostic relevance of pulmonary arterial compliance after therapy initiation or escalation in patients with pulmonary arterial hypertension.

Author

Ghio S, D'Alto M, Badagliacca R, Vitulo P, Argiento P, Mulè M, Tuzzolino F, Scelsi L, Romeo E, Raineri C, Martino L, Tamburino C, Poscia R, and Vizza CD

Subjects
Aged, Cardiac Catheterization, Cohort Studies, Female, Humans, Hypertension, Pulmonary diagnosis, Male, Middle Aged, Prognosis, ROC Curve, Vascular Resistance physiology, Hypertension, Pulmonary physiopathology, Hypertension, Pulmonary therapy, Pulmonary Artery physiopathology
Abstract

Background: Conventional hemodynamic parameters are considered to be the gold standard indices of outcome in pulmonary arterial hypertension (PAH); on the contrary, few data support the hypothesis that the pulsatile component of right ventricular afterload provides important prognostic information. The aim of the study was to investigate the prognostic significance of pulmonary arterial compliance (PCa) after therapy initiation or escalation in PAH patients., Methods: A cohort of 419 consecutive PAH patients (308 naive and 111 prevalent) underwent right heart catheterisation (RHC) prior to initiating or escalating PAH-targeted therapy. RHC was repeated in 255 patients (61%) after 4 to 12months of therapy as 62 patients (15%) died and 102 (24%) did not undergo a follow-up RHC within the first year., Results: After the follow-up RHC, 63 patients died over a median follow-up period of 39months. At multivariate analysis, age>50years old, male gender, etiology associated with systemic sclerosis, persistence of WHO class III/IV, and reduced PCa at follow-up RHC were the independent parameters significantly associated with poor prognosis. At ROC analysis, the optimal cut-off point of PCa to predict survival was 1.4mL/mmHg (AUC 0.73, sensitivity 81.8%, specificity 58.8%)., Conclusions: In PAH patients hospitalized to initiate or to escalate PAH-specific therapy, failure to improve PCa after therapy is a strong hemodynamic predictor of poor prognosis., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2017
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2. Quality of life following percutaneous mitral valve repair with the MitraClip System.

Author

Ussia GP, Cammalleri V, Sarkar K, Scandura S, Immè S, Pistritto AM, Caggegi A, Chiarandà M, Mangiafico S, Barbanti M, Scarabelli M, Mulè M, Aruta P, and Tamburino C

Subjects
Aged, Aged, 80 and over, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Mental Health, Middle Aged, Mitral Valve Insufficiency physiopathology, Motor Activity, Surveys and Questionnaires, Health Surveys, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Mitral Valve Insufficiency psychology, Mitral Valve Insufficiency surgery, Quality of Life
Abstract

Background: Percutaneous valve repair with MitraClip System is an emerging alternative for high surgical risk patients with severe mitral regurgitation (MR). QoL is a critical measure of effectiveness of this procedure. We sought to evaluate quality of life (QoL) and NYHA class following this novel procedure., Methods: The study included 39 consecutive patients who underwent mitral valve repair with the MitraClip System, both for functional (64%) and degenerative (36%) MR. All patients received the SF-12v2 questionnaire pre-procedure and at 6 months follow-up to assess the physical and mental health., Results: Acute procedural success was obtained in 100%. Three patients experienced minor procedural complications. At follow-up 86% of patients had MR ≤ 1+ and 14% experienced a moderate MR. Mean pre-procedural SF-12v2 scores of our patients showed a severe impairment of perceived QoL, both for physical and mental scores; after six months a striking improvement in physical (PCS 35.44 vs 44.67, p<0.0001) and mental (MCS 38.07 vs 46.94, p<0.0001) aspect of QoL was observed. Furthermore, physical and mental status upgrading was higher in patients with functional MR. NYHA functional class improved in all patients., Conclusion: Our results show an early marked improvement in functional status and physical and mental health in patients underwent percutaneous mitral valve repair with the MitraClip System., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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3. Combined endothelin receptor antagonist and transcatheter interventional therapy of patent ductus arteriosus with severe pulmonary artery hypertension.

Author

Ussia GP, Mulè M, Caruso E, Aiello R, and Tamburino C

Subjects
Bosentan, Ductus Arteriosus, Patent complications, Ductus Arteriosus, Patent drug therapy, Endothelin Receptor Antagonists, Humans, Hypertension, Pulmonary drug therapy, Hypertension, Pulmonary etiology, Male, Middle Aged, Antihypertensive Agents therapeutic use, Cardiac Catheterization, Ductus Arteriosus, Patent therapy, Hypertension, Pulmonary therapy, Sulfonamides therapeutic use
Abstract

The natural history of congenital heart disease (CHD) with left to right shunt and high pulmonary blood flow, is characterized by development of severe Pulmonary Artery Hypertension (PAH); this condition usually contraindicates any type of surgical or interventional cardiac correction because of bad results. We here report the case of an adult patient with a patent ductus arteriosus and severe PAH, treated uneventfully with a staged combined therapy: Bosentan for 3 months and then percutaneous closure with amplatzer duct occluder (AGA Med. Co. Golden Valley, MN). The patient showed a dramatic improvement both of pulmonary hemodynamics and functional capacity at 8 months follow up confirming the efficacy of pulmonary vasodilator therapy in PAH associated to congenital heart disease.

Published
2007
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