1. Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure
- Author
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Mateusz Garus, Marta Rosiek-Biegus, Mateusz Guzik, Dominik Marciniak, Robert Zymliński, Sylwia Nawrocka-Millward, Jan Biegus, Piotr Ponikowski, Barbara Ponikowska, Marat Fudim, and Jeffrey M. Testani
- Subjects
medicine.medical_specialty ,Population ,Renal function ,Kidney ,Natriuresis ,chemistry.chemical_compound ,Internal medicine ,Renin–angiotensin system ,Renin ,medicine ,Humans ,education ,Aldosterone ,Heart Failure ,education.field_of_study ,business.industry ,Furosemide ,medicine.disease ,Prognosis ,Blood pressure ,chemistry ,Heart failure ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
BACKGROUND Although renin-angiotensin-aldosterone system (RAAS) activation is believed to be the major driver of acute heart failure (AHF) episodes our understanding of its prevalence and clinical relevance in contemporary settings is incomplete. METHODS Serum renin and aldosterone were measured at day-1 and at discharge in patients (n = 211) that were hospitalized between 2016 and 2017 for AHF in a single cardiology center. The population was profiled based on upper limits of normal (ULN) of both biomarkers assessed at day-1 and linked with the clinical course and outcomes. RESULTS The study population constituted of three profiles: RAAS-/- (n = 121 [57%]); RAAS+/- (n = 60 [28%]); and RAAS+/+ (n = 30 [14%]). The RAAS+/+ profile had the lowest blood pressure and serum sodium at admission, day-2 and discharge compared to the other profiles (p
- Published
- 2021