43 results on '"Maffei"'
Search Results
2. Validity of epicardial fat volume as biomarker of coronary artery disease in symptomatic individuals: Results from the ALTER-BIO registry
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Milanese, Gianluca, Silva, Mario, Ledda, Roberta Eufrasia, Goldoni, Matteo, Nayak, Sundeep, Bruno, Livia, Rossi, Enrica, Maffei, Erica, Cademartiri, Filippo, and Sverzellati, Nicola
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- 2020
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3. Procalcitonin, white blood cell count and C-reactive protein as predictors of S. aureus infection and mortality in infective endocarditis
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Tascini, Carlo, Aimo, Alberto, Arzilli, Chiara, Sbrana, Francesco, Ripoli, Andrea, Ghiadoni, Lorenzo, Bertone, Chiara, Passino, Claudio, Attanasio, Vittorio, Sozio, Emanuela, Taddei, Eleonora, Murri, Rita, Fantoni, Massimo, Paciosi, Francesco, Francisci, Daniela, Pasticci, Maria Bruna, Pallotto, Carlo, Di Caprio, Giovanni, Carozza, Antonio, Maffei, Stefano, and Emdin, Michele
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- 2020
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4. Women-specific predictors of cardiovascular disease risk - new paradigms
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Maffei, Silvia, Guiducci, Letizia, Cugusi, Lucia, Cadeddu, Christian, Deidda, Martino, Gallina, Sabina, Sciomer, Susanna, Gastaldelli, Amalia, and Kaski, Juan-Carlos
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- 2019
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5. Sex-related differences in chronic heart failure
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Aimo, Alberto, Vergaro, Giuseppe, Barison, Andrea, Maffei, Silvia, Borrelli, Chiara, Morrone, Doralisa, Cameli, Matteo, Palazzuoli, Alberto, Ambrosio, Giuseppe, Coiro, Stefano, Savino, Ketty, Cerbai, Elisabetta, Marcucci, Rossella, Pedrinelli, Roberto, Padeletti, Luigi, Passino, Claudio, and Emdin, Michele
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- 2018
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6. Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study
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Andreini, Daniele, Pontone, Gianluca, Mushtaq, Saima, Gransar, Heidi, Conte, Edoardo, Bartorelli, Antonio L., Pepi, Mauro, Opolski, Maksymilian P., ó Hartaigh, Bríain, Berman, Daniel S., Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Marques, Hugo, Rubinshtein, Ronen, Hindoyan, Niree, Gomez, Millie, and Min, James K
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- 2017
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7. Atrial chamber remodelling in healthy pre-adolescent athletes engaged in endurance sports: A study with a longitudinal design. The CHILD study
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D'Ascenzi, Flavio, Solari, Marco, Anselmi, Francesca, Maffei, Silvia, Focardi, Marta, Bonifazi, Marco, Mondillo, Sergio, and Henein, Michael
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- 2016
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8. Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy
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Landolfi, Alessandro, Selvetella, Giulio, Cugino, Daniela, Grillea, Giovanni, Maffei, Angelo, Notte, Antonella, Lembo, Giuseppe, and Carnevale, Daniela
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- 2016
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9. The presence of remodeled and mixed atherosclerotic plaques at coronary ct angiography predicts major cardiac adverse events — The CAFÉ-PIE Study
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Guaricci, Andrea Igoren, Pontone, Gianluca, Brunetti, Natale Daniele, De Rosa, Fiorella, Montrone, Deodata, Guglielmo, Marco, Mushtaq, Saima, Fusini, Laura, Maffei, Erica, Cademartiri, Filippo, Macarini, Luca, Andreini, Daniele, Di Biase, Matteo, Bartorelli, Antonio L., and Pepi, Mauro
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- 2016
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10. The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study
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Nicoll, R., Wiklund, U., Zhao, Y., Diederichsen, A., Mickley, H., Ovrehus, K., Zamorano, P., Gueret, P., Schmermund, A., Maffei, E., Cademartiri, F., Budoff, M., and Henein, M.
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- 2016
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11. Do SGLT2 inhibitors protect elderly patients from HF rehospitalization and CKD progression? More opportunities than concerns
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Galassi, Andrea, primary, Cara, Anila, additional, Magagnoli, Lorenza, additional, Faccioli, Federico Maffei, additional, and Cozzolino, Mario, additional
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- 2023
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12. Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography
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Guaricci, Andrea Igoren, Arcadi, Teresa, Brunetti, Natale Daniele, Maffei, Erica, Montrone, Deodata, Martini, Chiara, De Luca, Maria, De Rosa, Fiorella, Cocco, Domenico, Midiri, Massimo, Cademartiri, Filippo, Macarini, Luca, Di Biase, Matteo, and Pontone, Gianluca
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- 2014
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13. Heart rate control with oral ivabradine in computed tomography coronary angiography: A randomized comparison of 7.5 mg vs 5 mg regimen
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Guaricci, Andrea Igoren, Maffei, Erica, Brunetti, Natale D., Montrone, Deodata, Di Biase, Luigi, Tedeschi, Carlo, Gentile, Giovanni, Macarini, Luca, Midiri, Massimo, Cademartiri, Filippo, and Di Biase, Matteo
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- 2013
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14. Alström Syndrome: Cardiac Magnetic Resonance findings
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Corbetti, Francesco, Razzolini, Renato, Bettini, Vera, Marshall, Jan D., Naggert, Jürgen, Tona, Francesco, Milan, Gabriella, and Maffei, Pietro
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- 2013
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15. Do SGLT2 inhibitors protect elderly patients from HF rehospitalization and CKD progression? More opportunities than concerns
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Andrea Galassi, Anila Cara, Lorenza Magagnoli, Federico Maffei Faccioli, and Mario Cozzolino
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Settore MED/14 - Nefrologia ,Cardiology and Cardiovascular Medicine - Published
- 2023
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16. Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography
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Guaricci, Andrea I., Schuijf, Joanne D., Cademartiri, Filippo, Brunetti, Natale Daniele, Montrone, Deodata, Maffei, Erica, Tedeschi, Carlo, Ieva, Riccardo, Di Biase, Luigi, Midiri, Massimo, Macarini, Luca, and Di Biase, Matteo
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- 2012
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17. Validity of epicardial fat volume as biomarker of coronary artery disease in symptomatic individuals: Results from the ALTER-BIO registry
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Gianluca Milanese, Matteo Goldoni, Livia Bruno, Roberta Eufrasia Ledda, Nicola Sverzellati, Enrica Rossi, Filippo Cademartiri, Sundeep Nayak, Erica Maffei, and Mario Silva
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medicine.medical_specialty ,Coronary Artery Disease ,Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Logistic regression ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Hounsfield scale ,Internal medicine ,Humans ,Medicine ,Registries ,cardiovascular diseases ,030212 general & internal medicine ,business.industry ,medicine.disease ,Predictive value ,Epicardial fat ,medicine.anatomical_structure ,Adipose Tissue ,Cardiology ,Biomarker (medicine) ,Cardiology and Cardiovascular Medicine ,business ,Pericardium ,Biomarkers ,Artery - Abstract
Background To determine if an increased epicardial fat volume (EFV) is associated with coronary artery disease (CAD) in individuals with symptoms of cardiovascular (CV) disease. Methods Coronary Computed Tomographic Angiography (CCTA), demographic and clinical variables of 1344 individuals were retrieved: semi-automated measurements for EFV and coronary artery calcifications (CAC) were obtained. Individuals were grouped into three categories according to the presence of CAD, resulting in absent (CAD0), non-obstructive (CAD1) or obstructive (CAD2) disease-groups. Relation of EFV with CAD was assessed with two approaches: 1) presence of any CAD; 2) each individual CAD category. Results Median EFV was 90.52 ml (range 11.27–442.21 ml); median CAC was 56.5 (range 0–10,144); 848 individuals (63.1%) were categorized as CAD0, 326 (24.3%) as CAD1, 170 (12.6%) as CAD2. EFV was lower in subjects without CAC (EFVmedian = 66.5 ml), as compared to those with CAC 0.1–100 (EFVmedian = 91.47), CAC 100.1–400 (EFVmedian = 97.46) and CAC >400 (EFVmedian = 109.48) (p EFV was lower in CAD0 (EFVmedian = 87.21 ml), as compared to CAD1 (EFVmedian = 93.89 ml) and CAD2 (EFVmedian = 102.98 ml) individuals (p A logistic regression model built by including demographic and clinical variables showed inconsistent predictive value of EFV for either CAD1 or CAD2 (p > 0.05). Conclusions In the setting of symptomatic individuals, an increased amount of epicardial fat was associated with larger amount of coronary artery calcifications and was observed in individuals with obstructive CAD, however without predictive value to confidently determine CAD presence and severity.
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- 2020
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18. Procalcitonin, white blood cell count and C-reactive protein as predictors of S. aureus infection and mortality in infective endocarditis
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Maria Bruna Pasticci, Lorenzo Ghiadoni, Carlo Pallotto, Alberto Aimo, Giovanni Di Caprio, Claudio Passino, Massimo Fantoni, Carlo Tascini, Andrea Ripoli, Rita Murri, Stefano Maffei, Emanuela Sozio, Antonio Carozza, Francesco Sbrana, Chiara Arzilli, Eleonora Taddei, Vittorio Attanasio, Chiara Bertone, Francesco Paciosi, Daniela Francisci, and Michele Emdin
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Male ,Staphylococcus aureus ,medicine.medical_specialty ,White blood cell count ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Risk Assessment ,Gastroenterology ,Procalcitonin ,C-reactive protein ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,Diagnostic Tests ,Predictive Value of Tests ,Internal medicine ,White blood cell ,medicine ,Humans ,Endocarditis ,Routine ,Hospital Mortality ,030212 general & internal medicine ,Aged ,S. aureus ,Biomarkers ,C-Reactive Protein ,Diagnostic Tests, Routine ,Female ,Italy ,Prognosis ,Endocarditis, Bacterial ,Staphylococcal Infections ,biology ,business.industry ,Bacterial ,Area under the curve ,medicine.disease ,medicine.anatomical_structure ,Infective endocarditis ,biology.protein ,Etiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Infective endocarditis (IE) is characterized by high rates of in-hospital death, and Staphylococcus aureus infection predicts a worse prognosis. We aimed to assess if admission inflammatory biomarkers (white blood cell – WBC – count, C-reactive protein — CRP, and procalcitonin) are informative on microbiological etiology and short-term outcomes. Methods Data from 236 patients admitted for IE from January 2013 to June 2018 were retrieved from a multicenter registry. Results Fifty-two patients (22%) were infected by S. aureus. WBC, CRP and procalcitonin had area under the curve (AUC) values for S. aureus infection of 0.595, 0.675, and 0.727, respectively. Adding procalcitonin to WBC improved discrimination over WBC alone (p = 0.045), and procalcitonin predicted S. aureus infection independently from the other inflammatory biomarkers and patient characteristics. Patients with WBC ≥ 12,800/mm3, CRP ≥ 130 mg/L, and procalcitonin ≥ 1.7 ng/mL had an almost 20-fold higher risk of S. aureus infection than patients with all biomarkers Conclusions Among patients with IE, high levels of inflammatory biomarkers on admission, particularly procalcitonin, are associated with a higher likelihood of S. aureus infection, and a higher risk of in-hospital mortality.
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- 2020
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19. Assessment of left ventricular diastolic events interrelations: An integrated approach
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Mondillo, Sergio, Ballo, Piercarlo, Galderisi, Maurizio, Focardi, Marta, Giacomin, Elisa, Maffei, Silvia, and Henein, Michael
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- 2010
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20. Arrhythmic profile and 24-hour QT interval variability in COVID-19 patients treated with hydroxychloroquine and azithromycin
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Cipriani, Alberto, Zorzi, Alessandro, Ceccato, Davide, Capone, Federico, Parolin, Matteo, Donato, Filippo, Fioretto, Paola, Pesavento, Raffaele, Previato, Lorenzo, Maffei, Pietro, Saller, Alois, Avogaro, Angelo, Sarais, Cristiano, Gregori, Dario, Iliceto, Sabino, and Vettor, Roberto
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- 2020
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21. Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women
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Maffei, Silvia, Mercuri, Antonella, Zucchelli, Gian Carlo, and Vassalle, Cristina
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- 2006
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22. Late potentials and ventricular arrhythmias in acromegaly
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Maffei, Pietro, Martini, Chiara, Milanesi, Anna, Corfini, Alberto, Mioni, Roberto, de Carlo, Eugenio, Menegazzo, Carla, Scanarini, Massimo, Vettor, Roberto, Federspil, Giovanni, and Sicolo, Nicola
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- 2005
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23. Vitamin K antagonist control in patients with atrial fibrillation in Asia compared with other regions of the world: Real-world data from the GARFIELD-AF registry
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Sakai, H., Saito, Y., Otaki, E., Ota, A., Oriso, S., Pearce, Y. Onuki, Furukawa, N., Fukui, T., Fukuda, T., Fujisawa, Y., Fujisawa, A., Fujiki, R., Fujii, Y., Endo, M., Emura, Y., Doiuchi, J., Date, H., Chibana, H., Betsuyaku, T., Baba, T., Azuma, J., Asano, T., Asano, H., Arino, T., Arima, S., Arai, H., Aoyama, T., Aoki, K., Amano, T., Akahane, K., Adachi, T., Adachi, S. (Susumu), Adachi, S. (Sen), Abe, Y., Nagasaka, S., Okuda, F., Mukawa, H., Wada, M., Minagawa, T., Ishiguro, M., Mizuguchi, M., Yoshida, T. (Tomoki), Yoshida, T. (Tetsuro), Neya, K., Soma, A., Shiga, Y. (Yukio), Sugishita, N., Horie, H. (Hajime), Miyagawa, K., Hibino, M., Hoshiai, M., Hosokawa, H., Hiramitsu, S., Seo, T., Ito, K., Nakano, M., Shibuya, M., Tomimoto, S., Kimura, T., Taga, K., Igarashi, M., Techigawara, M., Watanabe, H., Nakata, A., Katsube, Y., Ueda, T., Odakura, H., Inagaki, M., Akiyama, M., Imamaki, M., Kubo, H., Ko, T., Taniguchi, T., Hata, Y., Matsukawa, S., Murakami, H., Bang-Hansen, T., Raymond, I, Ibsen, H., Egstrup, K., Skagen, K., Dominguez, H., Mertz, J., Bruun, M., Loekkegaard, T., Simonsen, P., Solgaard, J., Boerger, J., Markenvard, J., Bremmelgaard, A., Rasmussen, S., Hintze, U., Husted, S., Nielsen, H., Nielsen, J., Zika, J., Zidek, M., Valtova, M., Sveceny, J., Sulc, A., Prochazkova, E., Potuznik, P., Michalik, D., Majernikova, M., Mahdalikova, L., Ludkova, A., Lubanda, H., Lipoldova, J., Lindourkova, A., Labrova, R., Krcova, E., Kratochvilova, R., Kopeckova, I, Janska, L., Hubacova, V, Horejsi, M., Honek, J., Drasnar, T., Kanokphatcharakun, K., Mongkolwongroj, P., Chawanadelert, S., Angchaisuksiri, P., Yun, S. Y., Yoon, E. J., Yoo, K. M., Yim, K. H., Ye, S., Woo, J. J., Wi, H. K., Song, H. J., Son, Y. S., Son, W. S., Sohn, Y. M., Sim, J. H., Shim, J., Seo, S-Y, Park, Y., Park, M., Park, J. H., Park, H. N., Park, B. R., Park, A. R., Noh, I. K., Lee, W. Y., Lee, S., Lee, S. H., Lee, S. E., Lee, R. W., Lee, M-Y, Lee, M. S., Lee, K. R., Lee, K. H., Lee, H-Y, Lee, H. Y., Lee, G. H., Lee, E. H., Lee, C. S., Kim, Y, Kim, S. H. (Sang Hyun), Fukuoka, S., Ikemura, M., Manita, M., Arasaki, O., Agata, J., Yoshizawa, N., Ashida, K., Kakinoki, S., Kusumoto, T., Matsuta, M., Fujito, T., Tanaka, M., Doi, H., Marusaki, S., Taguchi, T., Sakuma, I, Mita, T., Minami, J., Nagao, K., Mito, T., Saito, T., Abe, M. (Mitsunori), Abe, M. (Masatake), Abe, M. (Masahiko), Okawa, M., Fujii, M., Nakamura, Y. (Yuichiro), Iwaki, M., Miyamoto, N., Nagano, S., Takezawa, H., Oshiro, K., Nii, K., Kameko, M., Tabuchi, T., Seto, T., Nagoshi, T., Atsuchi, Y., Fujisawa, K., Sanno, K., Nagatomo, T., Sumi, H., Shiga, Y. (Yuhei), Morii, S., Unoki, T., Mishima, K., Go, Y., Oda, H. (Hiroyuki), Ageta, M., Oyama, R., Nakamura, Y. (Yoichi), Kitami, Y., Hatori, Y., Takeuchi, M., Tsuchida, K., Iwao, T., Yokota, N., Hoshino, F., Takamura, I, Akutsu, M., Shimoyama, M., Ogurusu, C., Murata, K., Nakatsuka, M., Ishizawa, M., Fujiura, Y. (Yoshitake), Ikeda, D., Yoshida, H., Eto, T., Gushiken, M., Higa, S., Kuwahata, T., Oba, I, Tachibana, H., Obunai, K., Fudo, T., Saito, K. (Kazuyuki), Saito, K. (Katsumi), Tsunoda, S., Kihara, H., Abe, S., Maekawa, H., Yamasawa, M., Wakasa, Y., Minamoto, M., Suetsugu, T., Ando, S., Noguchi, H., Misumi, I, Mizuno, Y., Toyota, F., Sadamatsu, K., Katsuda, Y., Kumagai, K., Yamamoto, K., Kanamori, S., Koretsune, Y., Panse, S. G., Vanajakshamma, V., Suresh, S., Singhal, S., Shiva, P., Sharma, M., Shah, D., Sadhu, N., Rao, N. M., Rao, M., Prashanth, K., Naik, D., More, P., Meena, R., Madarkar, N., Lokesh, B., Lawande, A., Krishnappa, S., Kaur, S., Kasala, L., Karthikeyan, R., Jain, V, Giradkar, S., Ganatra, A., Earath, M., Duhan, S., Dhyani, V, Dhakrao, P., Deshpande, B., Davies, D., Dargude, M., Bhattacharjee, P., Begum, H., Barai, A., Adak, D., Abraham, S., Jain, D., Kumar, S., Gupta, J. B., Khan, A., Bisne, V, Bantwal, G., Vijan, V. M., Vijayaraghavan, G., Raghuraman, B., Kothiwale, V. A., Chawla, K., Shah, S., Purayil, M. Padinhare, Pothiwala, R. A., Chandwani, P., Kulkarni, G., Kishore, R., Chopda, M., Nagamalesh, U. M., Roy, D., Srinivas, A., Ono, T., Ono, H., Okuyama, M., Okita, H., Okamoto, K., Okada, M., Ohara, N., Ogawa, T., Nozoe, M., Nomura, S., Nomura, K., Niwa, I, Nishizawa, K., Nishioka, H., Nishino, K., Nishihata, Y., Nishida, Y., Niinuma, H., Niijima, Y., Nariyama, J., Nanke, T., Nakazato, R., Nakayama, T., Nakanishi, N., Nakamura, R., Nakamura, M., Nakahara, S., Nakagomi, A., Nagata, H., Nagata, E., Nagai, S. (Shunichi), Nagai, S. (Sho), Murai, O., Morishita, K., Moriai, O., Mori, T., Mizuno, A., Mizuguchi, I, Miyata, S., Miyashita, A., Miyamoto, H., Miyajima, S., Miyaguchi, S., Miura, N., Mitsuhashi, H., Mineoi, K., Matsuura, Y., Matsushita, K., Matsui, S., Maruyama, Y., Maeda, K., Maeda, I, Kumazaki, T., Kumai, Y., Kozuka, T., Kotani, T., Koshibu, Y., Komatsu, I, Komatsu, H., Kojima, J., Koeda, T., Kobayashi, T., Kito, T., Kitazumi, H., Kitazawa, H., Kira, T., Kim, J., Kawano, S., Kawamoto, T., Kawakami, S., Kawakami, K., Kawai, K., Kawada, Y., Kato, Y., Kato, T., Kasai, T., Kano, H., Kaneko, M., Kanda, H., Kanai, H., Kamata, J., Kakuda, H., Iwase, T., Ito, N., Ishioka, N., Ishihara, A., Iseki, F., Inoue, T., Inaba, H., Imaizumi, M., Ikeoka, K., Ikeda, K., Ikeda, H., Iiji, O., Ido, T., Horie, H. (Hideki), Honda, M., Hirota, S., Hirose, M., Hirayama, H., Hirasawa, K., Higuchi, K., Hayashi, Y., Hatsuno, T., Hasegawa, K., Hanazono, N., Hamaoka, M., Goto, T., Furumoto, W., Furukawa, T., Sarma, R., Bhargava, K., Rajput, R. K., Shankar, A. G. Ravi, Durgaprasad, R., Jadhav, P., Sawhney, J. P. S., Kakkar, S., Zhu, X. Y., Zhou, Z. H., Zhou, B., Zheng, W. Y., Zhang, Y., Zhang, R., Zhang, Q., Zhang, G. S., Zhan, Q., Zhai, H., Yu, T., Yu, J. H., Yu, H. Y., Ye, Y., Yang, Q., Yang, L. L., Yang, J. S., Xu, R. Y., Xie, Q., Wu, R. N., Wang, L., Wang, K., Tian, G., Sun, Y. H., Shi, X. J., Sheng, X., Peng, J. Q., Ma, T. Y., Luo, X. L., Lu, Z. C., Liu, Y. Y., Liu, W. L., Liu, T. T., Li, Y. H., Li, L., Li, J., Li, B., Huang, X. F., Hu, X. S., He, X. A., He, R. H., Guo, W. N., Gao, X. J., Fu, Q. H., Feng, S., Chen, X., Chen, J. Y., Chen, J., Bai, C. L., Yang, Z. M., Li, H., Wang, F. Z., Xue, L., Guo, Y., Jiao, Y., Chen, P., Xiong, L. G., Chen, M. S., Zhao, R. P., Yan, X. W., Cheng, X. S., Wu, T. G., Li, X., Fu, G. S., Wang, Y. (Yong), Wang, Y. (Ying), He, S. H., Chen, Y. M., Yang, P., Tao, G. Z., Yin, Y. H., Li, W. H., Yang, Y. J., Wang, D. W., Cao, S. P., Chen, J. Z., Koretsune, Yukihiro, Ambrosio, Giuseppe, Agnelli, Giancarlo, Sawhney, Jitendra Pal Singh, Kakkar, Sanjay, Keltai, Matyas, Darius, Harald, Le Heuzey, Jean-Yves, Raatikainen, Pekka, Ragy, Hany, Nielsen, Jorn Dalsgaard, Jansky, Petr, Hu, Dayi, Corbalan, Ramon, Eikelboom, John, Spyropoulos, Alex, Connolly, Stuart J., Pereira Barretto, Antonio Carlos, Cools, Frank, Brodmann, Marianne, Gibbs, Harry, Lucas Luciardi, Hector, van Eickels, Martin, Misselwitz, Frank, Yilmaz, MEHMET BİRHAN, Lim, Toon Wei, Haas, Sylvia, Angchaisuksiri, Pantep, Goto, Shinya, Oh, Seil, Murakami, K., Kamogawa, Y., Tatematsu, H., Ogawa, J., Numata, H., Yoshimura, A., Fujiura, Y. (Yoshihisa), Zaitsu, R., Nandate, H., Nakamura, T. (Tsugihiro), Nakamura, T. (Tadashi), Kato, H., Miyagi, H., Suefuji, H., Haraguchi, Y., Minoda, K., Goto, K., Sonoda, R., Oba, Y., Matsumura, J., Murayama, T., Kumeda, K., Komaki, S., Azakami, S., Okada, K., Higashi, T., Ando, H., Koyanagi, T., Tsuruta, M., Norita, H., Chiba, K., Adachi, S., Shiraishi, K., Oda, H. (Hiroshi), Walton, S., Zhang, H. Q., Zhao, Y. S., Chen, K. N., Hu, D. Y., Fitzmaurice, David, Al Mahmeed, Wael, Parkhomenko, Alex, Oto, Ali, Steffel, Jan, Rosenqvist, Marten, Vinolas, Xavier, Jacobson, Barry, Panchenko, Elizaveta, Stepinska, Janina, Atar, Dan, Ten Cate, Hugo, Sanchez Diaz, Carlos Jerjes, Buzzetti, C., Kakkar, Ajay K., Kayani, Gloria, Camm, A. John, Accetta, Gabriele, Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. 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M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Mackay, S., Leung, D., Lehman, S., Lehman, M., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. 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Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Page, M., Giles, C., Jones, H., Sharp, H., Jefferies, A., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Dzeletovic, S., Bonkowski, G., Al-Khalili, F., Ahlmark, H., Ahbeck, E., Aaroe, H., Stalby, P., Hot-Bjelac, A., Thulin, J., Engdahl, J., Bernsten, F., Martinsson, B., Malmqvist, L., Andersson, A., Jensen, S. A., Karlsson, J-E, Crisby, M., Romberg, K., Timberg, I, Eriksson, B., Platonov, P., Handel, H., Thorne, K., Svensson, P., Lindvall, H., Ohlsson, A., Ericsson, M., Kadir, K., Hajimirsadeghi, A., Bothin, C., Benson, L., Andersson, L. (Lisbeth), Andersson, L. (Lars), Gustavsson, M., Olsson, L-B, Lindh, A., Liu, B., Svard, G., Borjesson, U., Egilsson, A., Elmersson, M., Henriksson, K., Linden, J., Wirdby, A., Rosenqvist, M., Ubeda Pastor, M., Torres Marques, J., Torres, C., Tobajas, G., Terns Riera, M., Teixido Fontanillas, M., Sorribes Lopez, J., Simon Valero, C., Sierra, N., Serralvo, E., Seoane Blanco, A., Senan Sanz, M. R., Santolaya, C., Sanchez Parra, S., Sanchez Mendez, L., Sanchez Calderon, P., Saez Jimenez, S., Rodriguez Garcia, M., Rodriguez, E., Rodrigo, C., Roca Saumell, C., Roca, M., Robiro Robiro, X., Rivera, R., Riquelme Sola, L., Merritt, D., Merliss, A., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Rios, V, Rincon Diaz, L. M., Renom, R., Quintern, V, Prieto, I, Perez Carasa, M., Pereda Armayor, M., Pena Garcia, E., Pareja Ibar, I., Palomo Merchan, N., Otero Tomera, D., Ortiz Cortes, C., Ortega, V. M., Orellana Figueroa, H. N., Negrete Palma, A., Munoz Munoz, R. B., Moure Gonzalez, M., Montes, D., Montero Alia, P., Molina, M., Millan, G., Mendez Zurita, F., Mazon, P., Martinez Mena, M., Martin Vila, A., Marcus, S., Mara Guerra, J., Manzanal Rey, A., Lopez, M., Llobet Molina, M., Lezcano Gort, L. E., Lasuncion, I, Lage Bouzamayor, M. B., Juan Salvadores, P., Jimeno Besa, B., Jimenez Fernandez, M. J., Iglesias Garcia, A., Hevia Rodriguez, E., Herrero Maeso, B., Gutierrez del Val, M. del C., Guerrero Molina, A., Grigorian, L., Gonzalez, P., Gonzales Segovia, A., Gomez Perez, Y., Gomez, C., Gines Garcia, C., Gavira Saenz, M., Garcia Millan, V, Garcia Bermudez, M., Fosch, J., Ferrer, A., Fernandez Mas, E., Fernandez Escobar, E., Fernandez, M., Espallargas, A., Elorriaga Madariaga, A., Domenech Borras, A., Diaz Lopez, C. M., Dachs, M., Cotilla Marco, M., Costas, S., Prego de Faria, J. Costa Pinto, Cortada Cabrera, A., Codinachs Alsina, R., Cebollada del Misterio, M., Castro Fernandez, D., Castillo Orive, M., Casanova Gil, M., Cancho Corchado, G., Campo Moreno, M., Calvo Martinez, E., Cabrera Ramos, M., Cabeza Ramirez, J., Branjovich Tijuan, A., Bermudez Jimenez, F. J., Becerra Munoz, V, Bartes, A., Barraquer Feu, E., Barbeira, S., Austria, A., Armitano Ochoa, R., Aracil Villar, J., Andere, N., Szkrobka, W., Szczepanska, A., Szalecki, P., Szafranski, J., Sukiennik-Kujawa, M., Stopyra-Poczatek, M., Starak-Marciniak, J., Staniszewska, E., Staneta, P., Splawski, M., Smichura, M., Skalska, J., Sidor, A., Rzyczkowska, B., Rychta, J., Rozewska-Furmanek, D., Roszczyk, N., Rostoff, P., Romaszkiewicz, R., Romanek, J., Rogowski, W., Raczynska, A., Ptaszynski, P., Piotrowicz, R., Pawlik-Rak, E., Pawelska-Buczen, A., Ozgowicz, M., Opielowska-Nowak, B., Nowak, S., Nowak, A., Niemirycz-Makurat, A., Niedek, J., Neubauer-Geryk, J., Mielcarek, M., Miedlar, E., Metzgier-Gumiela, A., Mazur, M., Markiewicz, A., Mariankowski, R., Majewska, K., Machnikowska, M., Lysek-Jozefowicz, A., Luka, J., Loboz-Rudnicka, M., Lip, K., Lichota, E., Lewicka, E., Leszczynski, J., Lesniewska-Krynska, D., Kustrzycka-Kratochwil, D., Kurdzielewicz, W., Krzyzanowski, M., Krzesiak-Lodyga, A., Kruczyk, D., Kremis, E., Kowalczyk, H. K., Kowal, E., Korczowska, E., Konopka, A., Komlo, A., Kolodzinska, A., Kociolek, D., Kochanska, E., Kobielusz-Gembala, I, Kluczewski, M., Klata, M., Kiliszek, M., Kaliszczak, R., Kalin, K., Kaczmarzyk-Radka, A., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Mooso, B., Minardo, J., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. S., Leese, J., Evans, R., Saunders, P., Goodwin, D., Chauhan, N., Fitzmaurice, D., Varenov, V., Todoriuk, L., Stets, R., Shumakov, O., Sapatyi, A., Romanova, O., Romanenko, O., Rasputina, L., Pyvovar, S., Proshak, O., Plevak, D., Petrovskyy, R., Pavelko, M., Palamarchuk, O., Ovdiienko, T., Nemtsova, V, Mospan, M., Mochonyi, V, Medentseva, O., Matova, O., Kizim, S., Khyzhnyak, O., Kaplan, P., Kamenska, E., Ivanov, A., Daniuk, I, Chabanna, O., Burdeuna, L., Berko, G., Belegai, R., Fushtey, I, Tykhonova, S., Yagensky, A., Kraydashenko, O., Stanislavchuk, M., Sychov, O., Svyshchenko, Y., Kovalskyi, I, Koval, O., Ushakov, O., Mostovoy, Y., Serediuk, N., Kupnovytska, I, Kraiz, I, Zhurba, S., Karpenko, O., Tseluyko, V, Rudyk, I, Parkhomenko, A., Winnik, S., Saga, E., Henriette, I, Guinand, A., Grau, A., Elise, G., Bruegger, J., Amstutz, D., Debrunner, J., Beer, J. H., Steffel, J., Thorsen, C., Stjernberg, M., Skoglund, K., Shayesteh, M., Samuelsson, J., Rosenberg, K., Risbecker, K., Pedersen, A., Osberg, A., Olofsson, A., Ohlin, A-M, Nilsson, C., Millborg, M., Mansson, K., Mannermyr, A., Lindholm, C-J, Lindberg, A., Lettenstrom, A., Kusiak, D., Koch, A., Kangert, R-M, Jansson, J-H, Jansson, B., Jaensson, P., Hahn, S., Grassjo, C., Floren, K., Eriksson, G-B, Ekstrand, A-B, Kabat, J., Jaworska-Drozdowska, M., Jaskulska-Niedziela, E., Jarzebowski, A., Jargiello-Baszak, M., Jaremczuk-Kaczmarczyk, A., Jankielewicz, J., Jaguszewska, G., Jackun-Podlesna, A., Guziewicz, M., Gutknecht, P., Gosciniecka, B., Gasior, E., Gadzinski, W., Frankiewicz, A., Figura-Chmielewska, M., Faron, W., Dziuba, M., Dybala, T., Dudzik-Richter, B., Drelich, L., Dolecka, B., Danilowicz-Szymanowicz, L., Czamara, M., Curyllo, B., Cieszynska, A., Cieslak, K., Cichomski, R., Chojnowski, P., Chmielowski, A., Bzymek, R., Brzustowska, M., Brzozowski, W., Broton, E., Blaszczyk, D., Biernacka, A., Biedrzycki, L., Bernat, L., Bekieszczuk, E., Basiak, M., Bartnik, J., Bartkowiak, R., Barszcz, A., Araminowicz, J., Andrzejewski, D., Ambicka, M., Lesnik, J., Nessler, J., Domanska, E., Raczak, G., Rusicka-Piekarz, T., Baszak, J., Lysek, R., Mazur, S., Myszka, W., Miekus, P., Jurowiecki, J., Cymerman, K., Galbas, K., Wozniak-Skowerska, I, Kukla, P., Okopien, B., Sciborski, R., Jaworska, K., Ruszkowski, P., Glanowska, G., Ogorek, M. (Michal), Bronisz, M., Opolski, G., Trusz-Gluza, M., Chmielnicka-Pruszczynska, M., Karczmarczyk, A., Zinka, E., Lewczuk, J., Ostrowska-Pomian, B., Lajkowski, Z., Krzciuk, M., Kania, G., Olszewski, M., Minc, P., Gruchala, M., Kucharski, L., Swiatkowska-Byczynska, L., Hiczkiewicz, J., Radics, Z., Marianna, S., Levang, S. Kovacsne, Kovacs, M., Gyorke, E. 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A., Barreda Gonzalez, M., Montero Alia, J. J., Escriva Montserrat, E., Del Val Plana, N., Almeida Fernandez, C. A., Epelde Gonzalo, F., Vida Gutierrez, M., Corros Vicente, C., Llibre, J. Bayo, Rodriguez Morato, M., Brotons Cuixart, C., Palacin Piquero, H., Monte Collado, I, Baron Esquivias, G., Gonzalez Juanatey, J. R., Merce Klein, J., Grande Ruiz, A., Iglesias Alonso, L. F., Moro Serrano, C., Gomez Pajuelo, C., Garcia Pavia, P., Motero Carrasco, J., Isart Rafecas, J., Marquez Contreras, E., Toran Monserrat, P., Tranche Iparraguirre, S., Tercedor, L., Lopez Fernandez, M. 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H. (Sang Hee), Kim, M. S., Kim, K. T., Kim, J. A., Kim, J. S. (Jung Sook), Kim, J. S. (Ji Seon), Kim, H. J. (Hyun Ju), Kim, H. J. (Hyeon Jeong), Jung, I-A, Jeong, H. K., Jeon, Y. R., Jeon, S. R., Jeon, H-G, Jang, S., Jang, H-S, Jang, E. M., Hwang, S. W., Her, K. O., Heo, E. S., Han, S., Choi, H. S., Choi, H. K., Choi, E. H., Choi, E. A., Chi, W. J., Baek, A. L., Bae, H., An, H. J., Ahn, J. J., Kim, D. B., Kim, C-J, Hwang, G-S, Jung, B. C., Kim, K-S, Kim, N-H, Yoon, J. H., Park, S. H., Hong, T. J., Cha, T-J, Kwak, J. J., Lim, H. E., On, Y. K., Nam, G-B, Cho, J-G, Sung, J. H., Han, S-J, Park, H. K., Park, J. S., Shin, D-G, Jeon, H-K, Kim, S-H, Cho, M-C, Oh, Y. S., Choi, D. J., Kim, D-K, Park, S. W., Ryu, D. R., Kim, D. H., Jang, S-W, Kim, J. H., Kim, J-B, Pak, H. N., Oh, S., Yeo, C., Yap, S. Y., Thng, S., Lim, W. T., Lim, G., Lee, Y. M., Jaufeerally, F. R., Dastychova, L., Chlumsky, J., Bultas, J., Bockova, L., Antonova, P., Durdil, V, Lastuvka, J., Novak, M., Vitovec, J., Spinar, J., Podrazil, P., Honkova, M., Dedek, V, Petrova, I, Pisova, J., Jerabek, O., Burianova, H., Monhart, Z., Kotik, I, Hubac, J., Ferkl, R., Racz, B., Plocova, K., Kotik, L., Olsr, J., Ludka, O., Zidkova, E., Machova, V, Spacek, R., Reichert, P., Jansky, P., Weyn, T., Vydt, T., Verloove, H., Vergauwen, L., Vantomme, C., Vanhauwaert, B., Vanhalst, E., Vandorpe, A., Vandenbroeck, D., Vandekerckhove, Y., Vandekerckhove, H., Van Lier, D., Van Durme, F., Tincani, G., Thyssen, V, Tahon, S., Stockman, I, Smolders, W., Smessaert, C., Simons, N., Semeraro, O., Scheurwegs, C., Salembier, J., Rombouts, H., Richa, J., Raymenants, E., Raepers, M., Postolache, A., Pollet, P., Piamonte, V, Nimmegeers, J., Mestdagh, I, Lips, S., Jacobs, C., Helvasto, L., Hellemans, S., Gits, F., Ghekiere, M., Feys, E., Eykerman, T., Everaert, M., Drieghe, S., Dormal, F., Deweerd, E., Derycker, K., Denie, D., Delvigne, M., Delforge, M., de Weerdt, N., de Vos, M., De Coninck, M., De Cleen, D., Conde Y Bolado, A., Casier, T., Capiau, H., Brike, C., Bouvy, C., Blockmans, M., Billiaux, A. C., Barbuto, A-M, Banaeian, F., Ascoop, A-K, Alzand, B., Hermans, K., Thoeng, J., Striekwold, H., Xhaet, O., Verstraete, S., Marechal, P., Beutels, M., Balthazar, Y., Faes, D., Blankoff, I, Purnode, P., Vercammen, J., Ann, W., Hollanders, G., Heyse, A., Voet, J., De Wolf, A., Godart, P., Boussy, T., Mairesse, G., Desfontaines, P., Wollaert, B., Vervoort, G., Capiau, L., Parque, J-L, Vandergoten, P., Paparella, G., Potito, R. N., Pontoriero, J., Perez Prados, G., Novas, V, Navarro, A., Munguia, R., Meirino, A., Mautner, B., Matkovich, J., Martinelli, C., Martinelli, A., Maffei, L., Maehara, G., Lopez, A., Ingratta, M., Chen, D. D., Chow, J. H., Foo, C. G., Ching, C. K., Lim, T. W., Yoshida, K., Yokoyama, Y., Yasui, K., Yamazoe, M., Yamaura, M., Yamamoto, T., Yamamoto, K. (Kunihiko), Yamamoto, K. (Kentaro), Yamamoto, K. (Kenichi), Yamaguchi, H., Yamagishi, T., Yamada, T., Watanabe, M., Washizuka, T., Wakiyama, T., Wakaki, N., Ueyama, Y., Ueda, O., Uchiyama, H., Tsuzaki, K., Tsuji, T., Tsuchiya, Y., Toru, S., Tohyo, S., Teragawa, H., Taya, K., Tanabe, G., Tana, T., Takenaka, K., Takei, K., Takeda, H., Take, S., Takanaka, C., Takai, H., Takahashi, S., Takahashi, K., Takagi, Y., Takagi, T., Taguchi, A., Tada, M., Suzuki, Y., Suzuki, S. (Susumu), Suzuki, S. (Shunji), Suzuki, S. (Shu), Suzuki, K. (Keita), Suzuki, K. (Kazuo), Sugimoto, C., Suga, T., Shozawa, Y., Shiraiwa, T., Shirai, T., Shinozuka, T., Shinohe, R., Shinohara, H., Shindo, T., Shimoyama, Y., Shimono, H., Shiina, Y., Shibata, N., Sezaki, K., Seta, Y., Sekine, Y., Seki, S., Sawano, M., Sato, K. (Kiyoharu), Sato, K. (Kazuki), Sasaki, T., Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., and Sakamoto, N.
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Male ,Pediatrics ,medicine.medical_specialty ,Asia ,Internationality ,Vitamin K ,medicine.drug_class ,Newly diagnosed ,030204 cardiovascular system & hematology ,Global Health ,03 medical and health sciences ,Antithrombotic treatment ,0302 clinical medicine ,Age groups ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,International Normalized Ratio ,Prospective Studies ,Registries ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,ta3121 ,Vitamin K antagonist ,medicine.disease ,Data Interpretation, Statistical ,Female ,Cardiology and Cardiovascular Medicine ,business ,Real world data - Abstract
Objective To compare the distribution of international normalized ratios (INRs) in patients receiving vitamin K antagonist (VKA) for newly diagnosed atrial fibrillation in Eastern and Southeastern Asia and in other regions of the world (ORW) represented in the ongoing, global observational study GARFIELD-AF. Methods and results 3621 and 13,541 patients were recruited prospectively in 2010–2013 from Asia and ORW, respectively. At baseline, excluding patients with unknown antithrombotic treatment, 1356 (37.8%) in Asia and 7081 (53.3%) in ORW received VKA (±antiplatelets). INR readings during 1-year follow-up were analyzed for VKA-treated patients with ≥3 measurements (878 [64.7%] patients in Asia, 4452 [62.9%] in ORW). VKA-treated patients in Asia were younger than those in ORW (mean 67.1 vs 71.3years), with a lower CHA 2 DS 2 -VASc score (3.0 vs 3.5), but a similar HAS-BLED score (1.3 vs 1.4). Mean INR was lower in Asia than in ORW (2.0 vs 2.4). The proportion of time in the therapeutic range, defined using the multinational target of 2.0–3.0, was substantially lower in Asia (31.1% vs 54.1%). In Asia and ORW, 59.3% and 28.2% of INRs were 3, respectively. The same trend was found in different age groups ( Conclusion GARFIELD-AF data demonstrate a difference in the distribution of INRs in patients from Asia versus other regions under current real-world practice. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2016
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24. The presence of remodeled and mixed atherosclerotic plaques at coronary ct angiography predicts major cardiac adverse events — The CAFÉ-PIE Study
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Marco Guglielmo, Luca Macarini, Matteo Di Biase, Saima Mushtaq, Filippo Cademartiri, Andrea Igoren Guaricci, Gianluca Pontone, Deodata Montrone, Laura Fusini, Fiorella De Rosa, Antonio L. Bartorelli, Mauro Pepi, Natale Daniele Brunetti, Daniele Andreini, Erica Maffei, and Radiology & Nuclear Medicine
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Male ,medicine.medical_specialty ,Computed Tomography Angiography ,030204 cardiovascular system & hematology ,Coronary Angiography ,Risk Assessment ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,In patient ,Prospective Studies ,cardiovascular diseases ,030212 general & internal medicine ,Acute Coronary Syndrome ,Adverse effect ,Aged ,business.industry ,Coronary computed tomography angiography ,Coronary ct angiography ,Middle Aged ,Prognosis ,medicine.disease ,Plaque, Atherosclerotic ,SSS ,ROC Curve ,Cardiology ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,Intermediate risk ,business ,Mace - Abstract
It is still unclear how to exploit information made available by coronary computed tomography angiography (CCTA) on coronary artery disease (CAD) features in order to better predicting major adverse cardiac events (MACEs). Aim of this study was to validate the prognostic role of a comprehensive and simplified CT-derived score in patients evaluated for suspected CAD.A prospective registry included 477 consecutive symptomatic patients without known CAD who underwent clinically-indicated CCTA. All patients were followed-up for MACE occurrence for a period of 49±15-month.The mean CT Score was 10.5±10.8, with a MACE rate of 11.3%. There was a stepwise relationship between MACE rate during follow-up and CT Score values. MACEs were 1.9% in patients with CT Score10 (reference group), 16.6% in those with CT Score 10-20 (OR 9.9, 95% C.I. 3.5-27.8 vs. reference group, p0.001), 24.5% in those with CT Score 21-30 (OR 16.6, 95% C.I. 6.1-45.0 vs. reference group, p0.001), and 47.4% in those with CT Score30 (OR 46.1, 95% C.I. 13.0-162.9 vs. reference group, p0.001) (p for trend0.001). At ROC curve analysis, CT Score was the best predictor of MACE (AUC: 0.81, CI 95%: 0.78-0.84) as compared to Diamond and Forrester score (p0.001), segment stenosis score (p0.05) and segment involved score (p.0.01).The use of an integrated score obtained with CCTA and based on the presence of remodeled and mixed atherosclerotic coronary plaques may improve MACE prediction in symptomatic patients at intermediate risk outweighing that provided by standard clinical and CCTA scores.
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- 2016
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25. Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography
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Massimo Midiri, Erica Maffei, Joanne D. Schuijf, Matteo Di Biase, Luigi Di Biase, Riccardo Ieva, Carlo Tedeschi, Luca Macarini, Natale Daniele Brunetti, Andrea Igoren Guaricci, Filippo Cademartiri, Deodata Montrone, Guaricci, A, Schuijf, J, Cademartiri, F, Brunetti, N, Montrone, D, Maffei, E, Tedeschi, C, Ieva, R, Di Biase, L, Midiri, M, Macarini, L, Di Biase, M, and Radiology & Nuclear Medicine
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Male ,Coronary angiography ,medicine.medical_specialty ,Administration, Oral ,Computed tomography ,Coronary Artery Disease ,Coronary Angiography ,Computed tomography coronary angiography ,Heart Rate ,Internal medicine ,Heart rate ,Bradycardia ,medicine ,Humans ,Ivabradine ,In patient ,Prospective Studies ,Heart rate reduction ,Aged ,medicine.diagnostic_test ,business.industry ,Benzazepines ,Middle Aged ,Atenolol ,Coronary heart disease ,Blood pressure ,Anesthesia ,Cardiology ,Female ,Premedication ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background: Heart rate (HR) reduction is essential to achieve optimal image quality and diagnostic accuracy with computed tomography coronary angiography (CTCA). Administration of ivabradine could be an attractive alternative to beta-blockade to reduce HR. Methods: One-hundred-twenty-three patients referred for CTCA were prospectively enrolled. Patients were divided in two groups depending on the absence or presence of chronic beta-blockade treatment. Within the two groups patients were randomized to either no additional premedication or oral ivabradine for 5 days prior to CTCA. In presence of chronic beta-blockade therapy it was shifted to atenolol 50 mg twice a day for 5 days prior to CTCA. HR and blood pressure were assessed at admission (T0), immediately before CTCA (T1) and during CTCA (T2). The target HR was
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- 2012
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26. Cardioembolism and takotsubo syndrome: A case report
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Alessandro Capucci, Alessandro Maolo, Federico Guerra, Daniele Contadini, and Simone Maffei
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Acute coronary syndrome ,Takotsubo syndrome ,medicine.medical_specialty ,business.industry ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,medicine ,Cardiology ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Stroke - Published
- 2016
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27. Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography
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Teresa Arcadi, Andrea Igoren Guaricci, Fiorella De Rosa, Massimo Midiri, Erica Maffei, Maria De Luca, Luca Macarini, Gianluca Pontone, Chiara Martini, Deodata Montrone, Filippo Cademartiri, Matteo Di Biase, Domenico Cocco, Natale Daniele Brunetti, Guaricci, A, Arcadi, T, Brunetti, N, Maffei, E, Montrone, D, Martini, C, De Luca, M, De Rosa, F, Cocco, D, Midiri, M, Cademartiri, F, Macarini, L, Di Biase, M, Pontone, G, and Radiology & Nuclear Medicine
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Male ,medicine.medical_specialty ,Coronary atherosclerosi ,Coronary Artery Disease ,Coronary Angiography ,Carotid Intima-Media Thickness ,Severity of Illness Index ,Coronary artery disease ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Coronary computed tomography angiography ,Humans ,cardiovascular diseases ,Coronary atherosclerosis ,Aged ,Carotid intima media thickne ,business.industry ,Ultrasound ,Middle Aged ,medicine.disease ,Coronary arteries ,medicine.anatomical_structure ,Intima-media thickness ,ROC Curve ,cardiovascular system ,Cardiology ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Intermediate risk ,Tomography, X-Ray Computed ,Artery - Abstract
Background: There is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA). Methods: We enrolled 204 consecutive symptomatic patients (mean age: 61 +/- 10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values. Results: CIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05-1.42, p 0.01; HR 1.2, CI 1.01-1.41, p 0.03; HR 9.0, CI 1.37-59.7, p 0.02; HR 21.0, CI 2.40-184, p < 0.01; HR 1.2, CI 1.08-1.42, p < 0.01; HR 1.2, CI 1.08-1.42, p < 0.01, respectively). A cut-off value >1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques. Conclusions: CIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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- 2014
28. Atrial chamber remodelling in healthy pre-adolescent athletes engaged in endurance sports: A study with a longitudinal design. The CHILD study
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Silvia Maffei, Marco Bonifazi, Michael Y. Henein, Marco Solari, Sergio Mondillo, Francesca Anselmi, Marta Focardi, and Flavio D'Ascenzi
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Male ,medicine.medical_specialty ,Adolescent ,Athlete's heart ,Pre adolescents ,Echocardiography, Three-Dimensional ,3-dimensional echocardiography ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Atrial strain ,medicine ,athlete's heart ,Training ,Humans ,Heart Atria ,Child ,Swimming ,3 dimensional echocardiography ,Exercise Tolerance ,biology ,Athletes ,business.industry ,Medicine (all) ,Speckle-tracking echocardiography ,030229 sport sciences ,Atrial Remodeling ,biology.organism_classification ,Adaptation, Physiological ,medicine.anatomical_structure ,Echocardiography ,Physical therapy ,Cardiology and Cardiovascular Medicine ,Ventricular Function, Right ,Right atrium ,sense organs ,business ,Heart atrium - Abstract
Previous studies investigated the exercise-induced adaptation of left (LA) and right atrium (RA) in adults, but little is known about respective changes in the growing heart of children. We aimed to longitudinally investigate the effects of endurance training on biatrial remodelling in preadolescent athletes.Ninety-four children (57 endurance athletes, 37 sedentary controls; mean age 10.8±0.2 and 10.2±0.2years, respectively) were evaluated at baseline and after 5months by ECG and by two-dimensional, three-dimensional (3D) and speckle-tracking echocardiography. Athletes were trained at least 10h/week. The resting heart rate was lower in athletes (p=0.046) and decreased further after training (p0.0001). Neither athletes nor controls had ECG evidence for LA or RA enlargement. At baseline, indexed LA volumes did not differ between groups (p=0.14) but indexed RA dimensions were larger in athletes (p=0.007). After 5months, indexed LA volumes increased in athletes but not in controls (p0.0001, p=0.29; respectively) while indexed RA volumes increased in both groups (p0.0001, p=0.018; respectively). At the same time, slight differences in biatrial reservoir and contractile function were found either in athletes, as demonstrated by speckle-tracking echocardiography, but 3D-derived LA and RA ejection fraction remained stable in both groups.Endurance training influences the growing heart of preadolescent athletes with an additive increase in biatrial size, suggesting that morphological adaptations can occur also in the early phases of the sports career. Training-induced remodelling was associated with a preserved biatrial function, supporting the hypothesis of a physiological remodelling.
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- 2016
29. The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study
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Matthew J. Budoff, Axel Schmermund, Filippo Cademartiri, Michael Y. Henein, Erica Maffei, Urban Wiklund, Axel Cosmus Pyndt Diederichsen, Kristian A. Øvrehus, Pascal Gueret, Ying Zhao, Rachel Nicoll, Hans Mickley, P. Zamorano, and Radiology & Nuclear Medicine
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Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Computed Tomography Angiography ,Coronary stenosis ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,cardiovascular diseases ,Computed tomography angiography ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Coronary Stenosis ,nutritional and metabolic diseases ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Predictive value ,Coronary Vessels ,humanities ,Coronary Calcium Score ,body regions ,Stenosis ,Cross-Sectional Studies ,Coronary artery calcification ,Cardiology ,Regression Analysis ,Calcium ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
AIMS: In this retrospective study we assessed the predictive value of the coronary calcium score for significant (>50%) stenosis relative to conventional risk factors.METHODS AND RESULTS: We investigated 5515 symptomatic patients from Denmark, France, Germany, Italy, Spain and the USA. All had risk factor assessment, computed tomographic coronary angiogram (CTCA) or conventional angiography and a CT scan for coronary artery calcium (CAC) scoring. 1539 (27.9%) patients had significant stenosis, 5.5% of whom had zero CAC. In 5074 patients, multiple binary regression showed the most important predictor of significant stenosis to be male gender (B=1.07) followed by diabetes mellitus (B=0.70) smoking, hypercholesterolaemia, hypertension, family history of CAD and age but not obesity. When the log transformed CAC score was included, it became the most powerful predictor (B=1.25), followed by male gender (B=0.48), diabetes, smoking, family history and age but hypercholesterolaemia and hypertension lost significance. The CAC score is a more accurate predictor of >50% stenosis than risk factors regardless of the means of assessment of stenosis. The sensitivity of risk factors, CAC score and the combination for prediction of >50% stenosis when measured by conventional angiogram was considerably higher than when assessed by CTCA but the specificity was considerably higher when assessed by CTCA. The accuracy of CTCA for predicting >50% stenosis using the CAC score alone was higher (AUC=0.85) than using a combination of the CAC score and risk factors with conventional angiography (AUC=0.81).CONCLUSION: In symptomatic patients, the CAC score is a more accurate predictor of significant coronary stenosis than conventional risk factors.
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- 2015
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30. Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women
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Silvia Maffei, Cristina Vassalle, Antonella Mercuri, and Gian Carlo Zucchelli
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medicine.medical_specialty ,Epinephrine ,medicine.drug_class ,Administration, Oral ,Biological Availability ,Blood Pressure ,Prostacyclin ,6-Ketoprostaglandin F1 alpha ,Administration, Cutaneous ,Nitric Oxide ,Norepinephrine (medication) ,Norepinephrine ,Reference Values ,Internal medicine ,Humans ,Medicine ,Nitrites ,Cross-Over Studies ,Nitrates ,Endothelin-1 ,Estradiol ,medicine.diagnostic_test ,business.industry ,Estrogen Replacement Therapy ,Middle Aged ,medicine.disease ,Lipoproteins, LDL ,Postmenopause ,Vasodilation ,Menopause ,Treatment Outcome ,Endocrinology ,Blood pressure ,Vasoconstriction ,Estrogen ,Catecholamine ,Female ,Follicle Stimulating Hormone ,Cardiology and Cardiovascular Medicine ,business ,Lipid profile ,Biomarkers ,medicine.drug - Abstract
To evaluate whether the route of estrogen therapy (ET) may affect the levels of different vasoactive factors in healthy recent post-menopausal women.We conducted a cross-over study in 20 healthy nonsmoking women in recent postmenopause (1.8+/-0.1 years). Women received either 1-month oral-ET (O-ET, 2 mg oral micronized 17beta estradiol daily) or transdermal-ET regimen (T-ET, 17beta estradiol 1.5 mg gel daily) with a 1-month wash-out interval. Blood pressure, plasma levels of endothelin-1 (ET), 6-ketoPGF1a (6-ketoPG, prostacyclin metabolite), nitrite/nitrate (NOx), epinephrine (E) and norepinephrine (NE) and lipid profile were measured at baseline and after each treatment.Both regimens significantly reduced E (p0.01) and NE levels (p0.05). O-ET reduced low-density lipoproteins (LDL) levels (p0.05) and increased NOx values (p0.01). Neither regimen caused significant changes of ET or 6-ketoPG.Our results, obtained in healthy women in recent menopause, indicate that the ratio between vasodilator (NOx and prostacyclin) and vasoconstrictor (ET) bioavailability shifted towards the previous ones after O-ET, while it remained unchanged after T-ET; moreover, catecholamines levels were reduced by both treatments already from 1 month of therapy. These changes might represent very early beneficial effects evoked by ET on the cardiovascular system.
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- 2006
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31. Age at menopause: A fundamental data of interest to acquire in female patients' anamnesis
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Susanna Sciomer, Carlotta De Carlo, Silvia Maffei, and Federica Moscucci
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Gerontology ,medicine.medical_specialty ,Alternative medicine ,menopause ,Disease ,anamnesis ,gender medicine ,030204 cardiovascular system & hematology ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Gonadal Steroid Hormones ,Anamnesis ,Gynecology ,Physician-Patient Relations ,Pregnancy ,030219 obstetrics & reproductive medicine ,business.industry ,medicine.disease ,Postmenopause ,Menopause ,Cardiovascular Diseases ,Quality of Life ,Etiology ,Menarche ,Female ,Cardiology and Cardiovascular Medicine ,business ,Hormone - Abstract
Although menopause is a universal phenomenon among women, the timing of the onset and the duration of the menopausal transition and the timing of the final menstrual period are not so codified. Compelling evidence supports the idea that the different impact of cardiovascular disease and the differences in vascular biology in men and women may be, at least in part, related to the cardiovascular and metabolic effects of sex steroid hormones. Indeed, androgens and estrogens influence a multitude of vascular biological processes and their cardiovascular effects are multifaceted. Gender pharmacology has proven that men and women have tiny but not paltry different effects to the same drug. Estrogens exert potential beneficial effects on the cardiovascular system in both sexes. It is evident that there is a need for the physician who approaches the female patient, to stress the main anamnestic data concerning her hormonal life starting from menarche, through pregnancy, until menopause. Thus it will be not only a formality becoming a cornerstone of the first doctor-patient relationship, both for in- and outpatient, we will have a clear and complete representation of the etiology and evolution of cardiovascular diseases that increasingly afflict the female gender.
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- 2016
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32. Rapidly reversible ECG abnormalities in chronic secondary adrenal insufficiency
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C Martini, P Maffei, C Abrahamsohn, and S Cajola
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medicine.medical_specialty ,Chronic disease ,medicine.diagnostic_test ,business.industry ,Secondary adrenal insufficiency ,Internal medicine ,Adrenal insufficiency ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Electrocardiography - Published
- 2002
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33. Assessment of left ventricular diastolic events interrelations: an integrated approach
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Maurizio Galderisi, Marta Focardi, Elisa Giacomin, Sergio Mondillo, Piercarlo Ballo, Silvia Maffei, Michael Y. Henein, Mondillo, S, Ballo, P, Galderisi, Maurizio, Focardi, M, Giacomin, E, Maffei, S, and Henein, M.
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Male ,medicine.medical_specialty ,Left ventricular diastolic function ,M-mode ,Diastole ,Left ventricular diastolic function, M-mode, Tissue Doppler ,Sensitivity and Specificity ,Severity of Illness Index ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,Ventricule gauche ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Diastolic function ,Aged ,Echocardiography, Doppler, Pulsed ,Long axis ,Surgical approach ,business.industry ,Reproducibility of Results ,Integrated approach ,Middle Aged ,Doppler echocardiography ,Cardiology ,Female ,Tissue Doppler ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity - Abstract
Left ventricular (LV) diastolic function represents a complex performance that involves long axis displacement, myocardial lengthening velocities as well as cavity filling. The aim of this study was to assess the various diastolic event interrelations in a group of patients with different degrees of diastolic dysfunction.128 consecutive subjects with various degrees of diastolic impairment were studied by Doppler echocardiography. The amplitude of early diastolic (El) and late diastolic (Al) long axis lengthening was measured by M-mode and corresponding myocardial velocities (Ea and Aa) by Tissue Doppler. LV filling velocities were also acquired by spectral pulsed wave Doppler.Early diastolic long axis amplitudes and velocities correlated (r=0.73, P0.0001) as did late diastolic ones (r=0.67, P0.0001). El of ≤5.6 mm was 80.6% sensitive and 70.5% specific in predicting Ea of8.0 cm/s, a feature of LV impaired relaxation. El/Al correlated with Ea/Aa (r=0.78, P0.0001), as did E/El with E/Ea ratios (r=0.74, P0.0001). An E/El ratio17.3 cm/s/mm had 94.1% sensitivity and 87.4% specificity for predicting an E/Ea ratio15, a marker for raised LV filling pressures. El≤6.8 mm, total amplitude of diastolic motion (El+Al)≤11.5 mm, and E/El14.2 cm/s/mm were the best criteria to discriminate between normal diastolic function and pseudonormal/restrictive LV filling.Diastolic LV components of motion, amplitude and velocities are not independent, neither from each other nor from filling pressures. An integrated approach towards using them all in assessing diastolic function, particularly in patients with raised filling pressure should be of great clinical value.
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- 2009
34. Age at menopause: A fundamental data of interest to acquire in female patients' anamnesis
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Sciomer, Susanna, primary, De Carlo, Carlotta, additional, Moscucci, Federica, additional, and Maffei, Silvia, additional
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- 2016
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35. Cardioembolism and takotsubo syndrome: A case report
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Guerra, Federico, primary, Maffei, Simone, additional, Maolo, Alessandro, additional, Contadini, Daniele, additional, and Capucci, Alessandro, additional
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- 2016
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36. Myocardial vitamin E is consumed during cardiopulmonary bypass: indirect evidence of free radical generation in human ischemic heart
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Francesco Verunelli, Fulvio Ursini, Monica Baroni, Gualtiero Pelosi, Andrea Biagnini, Leonardo Salvatore, Renata Barsacchi, and Stefano Maffei
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Adult ,Male ,Resuscitation ,medicine.medical_specialty ,Time Factors ,Free Radicals ,Cardiopulmonary bypass time ,Biopsy ,medicine.medical_treatment ,Myocardial Ischemia ,Ischemia ,law.invention ,Indirect evidence ,law ,Internal medicine ,Cardiopulmonary bypass ,medicine ,Humans ,Vitamin E ,Heart Atria ,Intraoperative Complications ,Chromatography, High Pressure Liquid ,Aged ,Cardiopulmonary Bypass ,business.industry ,Middle Aged ,medicine.disease ,Moderate hypothermia ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Ischemic heart - Abstract
Although a role for free radicals in myocardial damage during cardiopulmonary bypass for open heart surgery has been postulated, direct evidence of free radical production as well as consumption of tissue antioxidants such as vitamin E is still lacking. Twenty patients (age 26-66 yr, mean 48) undergoing elective open heart surgery with moderate hypothermia, and cold crystalloid cardioplegia, were studied. Cardiopulmonary bypass time was 61.4 +/- 31.2 min. The specimens of atrial tissue collection before and after cardiopulmonary bypass, were immediately frozen in liquid nitrogen. Mean vitamin E atrial content, measured by reverse phase HPLC, was 355 +/- 249 pmol/mg of dry weight basally, 135 +/- 85 pmol/mg (p0.05) at the end of the ischemic period and 405 +/- 288 pmol/mg after the reperfusion period (p0.01). Microscopic examination of right atrial biopsies ruled out differences in fibrosis or cellular damage as the cause of vitamin E changes. Although a great basal variability in atrial vitamin E content was observed, which was independent of age, sex and clinical status, a reproducible and substantial decrease in atrial vitamin E content after cardiopulmonary bypass occurred (mean reduction 45 +/- 17% and 55 +/- 22%, respectively, after ischemia and after reperfusion). This was directly related to the aorta cross-clamping duration and partially to the minimum temperature achieved. In conclusion, apart from the great variability observed in basal vitamin E tissue content, vitamin E was always reduced during cardiopulmonary bypass, suggesting an oxidative stress on the myocardium during open heart surgery.
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- 1992
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37. Late potentials and ventricular arrhythmias in acromegaly
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Massimo Scanarini, Nicola Sicolo, Roberto Mioni, Chiara Martini, Carla Menegazzo, Pietro Maffei, Roberto Vettor, Giovanni Federspil, Alberto Corfini, Anna Milanesi, and Eugenio De Carlo
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Tachycardia ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Heart disease ,Adolescent ,Action Potentials ,Left ventricular hypertrophy ,Sudden death ,Syncope ,QRS complex ,Internal medicine ,Acromegaly ,medicine ,Humans ,cardiovascular diseases ,Insulin-Like Growth Factor I ,Aged ,medicine.diagnostic_test ,business.industry ,Human Growth Hormone ,Signal Processing, Computer-Assisted ,Middle Aged ,medicine.disease ,Ventricular Premature Complexes ,Signal-averaged electrocardiogram ,Surgery ,Death, Sudden, Cardiac ,Echocardiography ,Case-Control Studies ,Cardiology ,Electrocardiography, Ambulatory ,Tachycardia, Ventricular ,Female ,Hypertrophy, Left Ventricular ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
Background Sudden death and increased prevalence of ventricular arrhythmias have already been described in acromegaly. Although late potentials (LPs) have been proved to be a new technique in detecting patients at risk for ventricular tachyarrhythmias its use in acromegaly is still unknown. Methods We studied 70 acromegalic patients [32 males, 38 females; age 49±12 years (mean±S.D.)] and 70 control subjects age- and sex-matched [(35 males and 35 females; 46±12 years (mean±S.D.)]. Besides hormonal tests, we performed the following cardiovascular investigations: ECG, 24-h ECG Holter monitoring, echocardiography, and signal-averaged ECG (SAECG) time-domain analysis. Results LPs occurrence was significantly higher in acromegalic patients as compared to the control group (22.9% vs. 2.9%; p =0.001). A greater duration of disease in patients with positive LPs compared to negative ones was pointed out (18 vs. 12 years; p =0.024). In the group of acromegalic patients with positive LPs we observed a significant association with premature ventricular complexes (PVCs) detected by means of 24-h Holter ECG recording (13 out of 15 patients: 86.7%; p =0.024). The positivity or negativity of LPs proved to be significantly associated with Lown scale PVC trends recorded by 24-h Holter ECG ( p =0.014). In the group of patients with left ventricular hypertrophy a significant and pathological worsening of SAECG signals (QRS, LAS, RMS) was documented. Conclusions We observed a higher prevalence of LPs in acromegaly which significantly correlated with Lown scale of PVCs.
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- 2004
38. Levosimendan improves pro/anti-inflammatory cytokines imbalance in male patients with advanced heart failure. A randomized, double-blind, placebo-controlled study
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Anna Laura Pasqui, Michela Di Renzo, G. Pompella, Alberto Auteri, Silvia Maffei, and Luca Puccetti
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Male ,Inotrope ,medicine.medical_specialty ,Heart disease ,Vasodilator Agents ,Diastole ,Hemodynamics ,Placebo ,Proinflammatory cytokine ,Placebos ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Simendan ,Heart Failure ,business.industry ,Hydrazones ,Levosimendan ,medicine.disease ,Pyridazines ,Treatment Outcome ,Endocrinology ,Heart failure ,Cardiology ,Cytokines ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Levosimendan is an inotropic and vasodilator drug with hemodynamic effects in patients with decompensated chronic heart failure. Levosimendan exerts its inotropic effects by increasing the sensitivity of the contractile apparatus to intracellular calcium and preserving the left ventricular (LV) diastolic relaxation at the same time [1]. Levosimendan also seems to have anti-inflammatory and antiapoptotic properties in decompensated heart failure [2,3]. Proinflammatory cytokines can modulate cardiac functions by a variety of mechanisms which promote the transition from asymptomatic to symptomatic heart failure since they depress myocardial contractility, promote cardiomyocyte apoptosis and contribute to cardiac remodeling [4–7]. The activity of inflammatory cytokines is also influenced by anti-inflammatory cytokines such as interleukin (IL)10 which can downregulate the production of several inflammatory cytokines from macrophages and other immune cells [8]. The specific aim of the present study was to investigate the effects of levosimendan or placebo on the balance between pro-inflammatory (TNFα and IL6) and anti-inflammatory (IL10) cytokines in patients affected by congestive heart failure treated with on-top medical therapy and the relation with hemodynamic parameters. The study population consisted of fifty-eight male patients with decompensated heart failure defined as functional class III–IV or IV according to NYHA criteria. The aetiology was ischemic cardiopathy in themajority of cases (50 out of 58, 86%). The diagnosis of CHFwas based on clinical and echocardiographic criteria. Each patient gave informed consent before entering the study. Patients were randomized to receive double-blind treatmentwith either intravenous levosimendan (Simdax, Abbott Laboratories) [n=29, ten min intravenous bolus (6 μg/kg) followed by a 0.1 μg/kg/min continuous intravenous infusion over twenty-four hours] or placebo (n=29). Blood samples were collected by venipuncture at baseline and at forty-eight hours, seven days, one month after the end of infusion to detect serum IL6, TNFα and IL10 as
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- 2011
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39. Heart rate control with oral ivabradine in computed tomography coronary angiography: A randomized comparison of 7.5mg vs 5mg regimen
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Guaricci, Andrea Igoren, primary, Maffei, Erica, additional, Brunetti, Natale D., additional, Montrone, Deodata, additional, Di Biase, Luigi, additional, Tedeschi, Carlo, additional, Gentile, Giovanni, additional, Macarini, Luca, additional, Midiri, Massimo, additional, Cademartiri, Filippo, additional, and Di Biase, Matteo, additional
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- 2013
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40. Levosimendan improves pro/anti-inflammatory cytokines imbalance in male patients with advanced heart failure. A randomized, double-blind, placebo-controlled study
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Pasqui, Anna Laura, primary, Maffei, Silvia, additional, Di Renzo, Michela, additional, Pompella, Gerarda, additional, Auteri, Alberto, additional, and Puccetti, Luca, additional
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- 2011
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41. Emergency pacemaker implantation in acromegaly
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Maffei, Pietro, primary, Martini, Chiara, additional, Mioni, Roberto, additional, DeCarlo, Eugenio, additional, Vettor, Roberto, additional, and Sicolo, Nicola, additional
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- 2004
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42. Rapidly reversible ECG abnormalities in chronic secondary adrenal insufficiency
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Maffei, P, primary, Cajola, S, additional, Abrahamsohn, C, additional, and Martini, C, additional
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- 2002
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43. Myocardial vitamin E is consumed during cardiopulmonary bypass: indirect evidence of free radical generation in human ischemic heart
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Barsacchi, Renata, primary, Pelosi, Gualtiero, additional, Maffei, Stefano, additional, Baroni, Monica, additional, Salvatore, Leonardo, additional, Ursini, Fulvio, additional, Verunelli, Francesco, additional, and Biagnini, Andrea, additional
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- 1992
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