1. Myocardium-targeted transplantation of mesenchymal stem cells by diagnostic ultrasound-mediated microbubble destruction improves cardiac function in myocardial infarction of New Zealand rabbits
- Author
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Xu, Ya-Li, Gao, Yun-Hua, Liu, Zheng, Tan, Kai-Bin, Hua, Xing, Fang, Zhen-Qiang, Wang, Ya-Li, Wang, Ya-Jie, Xia, Hong-Mei, and Zhuo, Zhong-Xiong
- Subjects
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HEART transplantation , *STEM cell transplantation , *DIAGNOSTIC ultrasonic imaging , *HEART function tests , *MYOCARDIAL infarction , *LABORATORY rabbits - Abstract
Abstract: Background: Therapeutic ultrasound-mediated microbubble destruction has been applied in the targeted delivery of genes, drugs and stem cells. We intended to study whether diagnostic US irradiating lipid-coated microbubble destruction combined with bone-marrow derived MSC infusion could enable the targeted delivery of MSCs into the myocardium and improve cardiac function of the myocardial infarction of New Zealand rabbits. Methods: Diagnostic ultrasound was applied to the anterior chest for 10 min after intravenous injection of lipid-coated microbubble followed by infusion of BM-MSCs. Echocardiography, histological examination, and western blotting were performed 4 weeks after cell transplantation. Results: The cardiac function (assessed by fractional shortening and ejection fraction) was markedly improved by US+Microbubble+MSC treatment. The number of capillaries stained by HE in US+Microbubble+MSC group (47±23) was much greater than that of the MSCs infusion group (26±7), US+Microbubble group(22±5) and PBS infusion group (19±10), P <0.01. US+Microbubble stimulation induced the expression of adhesion molecule (VCAM-1) in capillaries and enhanced the myocardial permeability of microvessels. US+Microbubble-mediated supply of MSCs increased the level of VEGF in ischemic myocardium. Area of cardiac fibrosis in the US+Microbubble+MSC group was significantly decreased by 25.6%,40.1% and 46.8% when compared with MSC infusion group, US+Microbubble group and PBS infusion group, respectively. Conclusions: This non-invasive cell delivery system may be useful as a novel and efficient approach for angiogenic cell therapy to the infarcted myocardium. [Copyright &y& Elsevier]
- Published
- 2010
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