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Background: This study was conducted with the aim to investigate the effectiveness of a psychological bioenergy economy intervention on the cardiac function and inflammatory factors in patients with myocardial infarction (MI). Methods: This randomized controlled trial (RCT) was performed on 60 post-MI patients who referred to the Cardiovascular Research Institute, Isfahan, Iran, in 2019. The intervention group received an energy-based bioenergetics intervention that consisted of rehabilitation training and nutrition patterns training. In the control group, only rehabilitation training and nutrition pattern training was provided in 8 sessions. Quantitative data were expressed as mean ± standard deviation (SD). Between-group differences of data departing from normal distribution were analyzed using the Mann-Whitney U test. All statistical analyses were performed in SPSS software. Results: The enrolled patients included 60 post-MI patients (27.3% women in the intervention group, and 18.2% in the control group). We lost 16 patients during the study. Fasting blood sugar was higher in the control group before the intervention (106.7 ± 14.1 vs. 96.3 ± 11.0; P < 0.001). Systolic blood pressure was significantly higher in the control group before the intervention (P = 0.04). There was no significant difference in total cholesterol, TG, HDL, and LDL after the intervention compared to before the intervention in either groups. Intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) did not change during the intervention in either groups (P < 0.05). Conclusion: Our results displayed that the psychological intervention based on bioenergy economy has no significant effect on cardiac function and inflammatory factors in patients with MI. However, it is suggested that this study be repeated on a larger population.