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A periodic pulse differential equation model of tumor immunotherapy is established by considering the periodic and transient behavior of infusing immune cells. Using comparison theorem and Floquet multiplier theory of the impulsive differential equation, the boundedness of the model solution, the existence and stability of the free-tumor periodic solution are given. Furthermore, the persistence of the system is analyzed. Numerical simulations are carried to confirm the main theorems.

In this paper, a reaction–diffusion model describing temporal development of tumor tissue, normal tissue and excess H+ ion concentration is considered. Based on a combination of perturbation methods, the Fredholm theory and Banach fixed point theorem, we theoretically justify the existence of the traveling wave solution for this model.