1. Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice
- Author
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Xiaoyan Jiang, Jianhua Cai, Hongya Xu, Na Liu, Siying Li, Xiaosong Zhu, Zhongxi Zhao, Jimin Cao, and Shanzhong Li
- Subjects
0301 basic medicine ,Lung Neoplasms ,Cell Survival ,Cell ,Diallyl trisulfide ,cisplatin ,Antineoplastic Agents ,Apoptosis ,Sulfides ,Applied Microbiology and Biotechnology ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,In vivo ,attenuate side effect ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Lung cancer ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Cisplatin ,Caspase 3 ,Cell Biology ,Cell cycle ,Cadherins ,medicine.disease ,G1 Phase Cell Cycle Checkpoints ,Xenograft Model Antitumor Assays ,In vitro ,Allyl Compounds ,Matrix Metalloproteinase 8 ,030104 developmental biology ,medicine.anatomical_structure ,Matrix Metalloproteinase 9 ,chemistry ,enhanced effect ,Cancer research ,Female ,lung carcinoma ,Research Paper ,Developmental Biology ,medicine.drug - Abstract
Diallyl trisulfide (DATS), an organosulfuric component of garlic oil, exhibits potential anticancer and chemopreventive effects. Cisplatin (DDP), a common chemotherapeutic agent, has provided great therapeutic contributions to treating solid tumors, but with serious side effects. Here, we verified the anti-tumor properties of DATS on lung cancer in vitro and in vivo, and evaluated synergistic effects of DATS combined with DDP on the NCI-H460 xenograft model. Significantly decreased cell viabilities, cell cycle G1 arrest, and apoptosis induction were observed in DATS treated NCI-H460 cells (p
- Published
- 2017