1. Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study
- Author
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Deepak N. Kapoor, Bhupinder Kapoor, Niraj Kumar Jha, Veera Venkata Satyanarayana Reddy Karri, Prapti Pattanayak, Dinesh Kumar Chellappan, Gaurav Gupta, Monica Gulati, Narendra Kumar Pandey, Sachin Kumar Singh, Kamal Dua, Rubiya Khursheed, A. Sharni, Sheetu Wadhwa, and Sumana Mondal
- Subjects
Ganoderma ,Polymers ,Drug Compounding ,02 engineering and technology ,Health benefits ,Polysaccharide ,Lipophilic drug ,0601 Biochemistry and Cell Biology ,Biochemistry ,03 medical and health sciences ,Sem micrographs ,chemistry.chemical_compound ,Drug Stability ,Structural Biology ,Molecular Biology ,Dissolution ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Drug Carriers ,Chromatography ,biology ,Chemistry ,Probiotics ,Fungal Polysaccharides ,General Medicine ,021001 nanoscience & nanotechnology ,biology.organism_classification ,Solvent ,Solubility ,Quercetin ,Powders ,0210 nano-technology - Abstract
Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to function as functional excipients i.e. as adsorbent that may provide therapeutic benefits. Quercetin (QUR) has been used as model lipophilic drug in this study. QUR loaded liquisolid compacts (LSCs) were formulated using Tween 80 as solvent. These were further solidified using a combination of PB and GLEP as carriers. Aerosil-200 (A-200) was used as coating agent. The formulation exhibited very good flow characteristics. Dissolution rate of raw QUR was found to be less than 10% in 60 min while in case of QUR loaded LSCs, more than 90% drug release was observed within 5 min. Absence of crystalline peaks of QUR in the DSC and PXRD reports of LSCs and their porous appearance in SEM micrographs indicate that QUR was successfully incorporated in the LSCs. The developed formulation was found to be stable on storage under accelerated stability conditions.
- Published
- 2021