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In the present paper, a double layer advanced model was used to investigate the adsorption process putatively involved in the olfactory perception of sotolone and abhexone molecules on the human olfactory receptor OR8D1. The number of adsorbed molecules or the fraction of adsorbed molecule per site, n, informed that the two odorants molecules are docked on OR8D1 binding sites with mixed parallel and nonparallel anchorages. Furthermore, the estimated molar adsorption energy (-ΔE 1 and -ΔE 2 ) were inferior to 40 kJ/mol for the two adsorption systems, which confirmed the physical nature and the exothermic character of the adsorption process. In addition, stereographic characterizations of the receptor sites surface were carried out through the determination of the receptor site size distribution (RSDs) via Kelvin equation, which spread out from 0.05 to 1.5 nm. The adsorption energy distributions (AEDs) via Polayni equation show an adsorption band spectrum localized between 17 kJ/mol and 22.5 kJ/mol for sotolone and abhexone molecules respectively. A molecular docking calculation was performed. The results indicate that the binding affinities are belonging to the spectrum of the energy band of the molecules sotolone and abhexone, with values 19.66 kJ/mol and 19.24 kJ/mol., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)