14 results on '"Piccoli G"'
Search Results
2. Blood Pressure Behaviour in Hemodialysis Patients Treated for 10 Years
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Degli Esposti, E., Boero, R., Chiarini, C., Negroni, D., Quarello, F., Santoro, A., Sturani, A., Zuccalà, A., Piccoli, G., and Zucchelli, P.
- Abstract
A longitudinal analysis of blood pressure was performed in 30 patients on hemodialysis for at least 10 years, in order to clarify the long-term outcome of hypertension in dialysis patients. Before the start of the dialysis treatment 22 (73.3%) patients were hypertensive, while, after 10 years, only 5 (16.6%) were still hypertensive. Body weight tended to decrease progressively thoughout the period of observation. Hypertension disappeared in the younger patients while it remained/appeared in those who were order showing the characteristics of systolic hypertension. Except for hematocrit no significant differences in metabolic findings were found between normotensive and hypertensive patients. ECG abnormalities were found to be more frequent after 10 years of dialysis than before the start of treatment. High blood pressure tends to disappear progressively in hemodialysis patients and to be no longer a problem in long-term survivors.
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- 1983
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3. Correlations between Bone Histopathology and Serum Biochemistry in Uremic Patients on Chronic Hemodialysis
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Canavese, C., Barolo, S., Gurioli, L., Cadario, A., Portigliatti, M., Isaia, G., Thea, A., Marangella, M., Bongiorno, P., Cavagnino, A., Peona, C., Boero, R., Damicone, M., Cardelli, R., Rossi, P., and Piccoli, G.
- Abstract
To define which noninvasive investigations are of value in predicting bone histology, we analyzed transiliac bone specimens (66 biopsies, 14 autopsies) from 80 uremic patients on chronic dialysis. Results were compared with values of different measurements of parathyroid hormone (PTH), alkaline phosphatase (APH), osteocalcin, calcitonin, baseline and post-deferroxamine (DFO) aluminium (Al), - β2microglobulin, ferritin and bone mineral density Among histomorphometric parameters, woven osteoid, active osteoblastic surface and resorption surface showed the best correlations with dynamic and biochemical marks of active bone metabolism. Among biochemical parameters, intact PTH and APH were better related to histomorphometric and dynamic bone parameters than other PTH measurements as well as osteocalcin, while calcitonin was related to no parameters. Stainable Al alone, and not total bone Al content was related to bone histology. Baseline Al was related to lamellar osteoid, while post-DFO Al was related to stainable Al. β2microglobulin was positively related to active osteoid surface and ferritin was inversely related to the mineral apposition rate, while bone mineral density was related only to total bone volume.We conclude that, though definite diagnosis requires the use of histological methods, few simple biochemical parameters may offer insight to the bone metabolic status, useful to the physician in day to day clinical practice.
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- 1998
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4. The Immunological State in Chronic Renal Insufficiency
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Giacchino, F., Alloatti, S., Quarello, F., Bosticardo, G.M., Giraudo, G., and Piccoli, G.
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To evaluate the immunological state in chronic renal insufficiency, the Authors studied cellular and humoral immunity in 292 patients with chronic renal failure.They were divided into 3 groups: 1) 37 with creatinine clearance between 50 and 20 ml/min; 2) 57 with creatinine clearance between 20 and 8 ml/min; 3) 178 treated by hemodialysis.In vivo and in vitro tests, that is DNCB, PPD skin tests, spontaneous, active and EAC rosettes, surface membrane immunoglobulin test, complement (C3, C4) and serum immunoglobulins were taken as markers of the immune response.Cell-mediated immunity was found to be significantly impaired in patients with terminal renal insufficiency or on hemodialysis and also markedly reduced in patients with non-terminal renal insufficiency.Humoral immunity produced less significant results: the B lymphocyte count and serum immunoglobulins were normal; only C3 levels were found below normal range.Thus it would seem that cell-mediated immunodeficiency appears in an early stage of chronic renal failure and that hemodialysis does not improve this deficiency.
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- 1982
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5. Lymphocyte Subsets Assayed by Numerical Tests in CAPD
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Giacchino, F., Pozzato, M., Formica, M., Quattrocchio, G., Quarello, F., Belardi, P., and Piccoli, G.
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Peripheral and peritoneal lumphocytes were assayed by numerical tests in adults on peritoneal dialysis. T lymphocytes were classified by monoclonal antibodies (OKT3, OKT4, OKT8) and B lymphocytes by the presence of surface immunoglobulins, using the immunofluorescence technique.Peripheral T cells showed no significant change from the normal, except for T suppressor cells which increased in patients with 2 or more peritonitis episodes.Examination of peritoneal lymphocytes showed a significant reduction in S-IgA lymphocytes (B cells bearing IgA receptors) and an increase in T-suppressor cells (OKT8+) in patients who developed peritonitis in the follow-up study. The implications of these results are discussed with particular reference to susceptibility to peritonitis.
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- 1984
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6. Ethics of Transplantation in the Medical School: A Pilot Study
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Piccoli, G.B., Soragna, G., Mezza, E., Putaggio, S., Garelli, G., Bermond, F., Burdese, M., Jeantet, A., Vercellone, F., Segoloni, G.P., and Piccoli, G.
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- 2004
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7. CKD patients and erythropoietin: do we need evidence-based informed consent?
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Mezza E, Consiglio V, Soragna G, Putaggio S, Burdese M, Perrotta L, Jeantet A, Segoloni GP, and Piccoli GB
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- Adult, Aged, Aged, 80 and over, Educational Status, Female, Health Knowledge, Attitudes, Practice, Humans, Italy, Kidney Failure, Chronic drug therapy, Kidney Transplantation, Male, Middle Aged, Nurses, Recombinant Proteins, Renal Dialysis, Students, Medical, Surveys and Questionnaires, Consent Forms standards, Erythropoietin therapeutic use, Evidence-Based Medicine, Informed Consent, Patient Education as Topic
- Abstract
Background: Consent to therapy is increasingly requested in the form of ''informed consent''., Objective: To validate an evidence-based informed consent form for erythropoietin (EPO) therapy and to evaluate patient opinions about the informed consent approach., Methods: An evidence-based informed consent form was developed as part of the Evidence-Based-Medicine course at the Medical School of Turin, Italy. It was validated by anonymous questionnaires (0-10 analogical scales and open answers) administered to patients at different stages of CKD (19 pre-ESRD, 26 hemodialysis, 12 transplant patients) attending an outpatient unit of the University of Turin, to 8 nurses, and to 26 medical students., Results: All individuals filled in the questionnaire. Interest in a detailed explanation of the therapy was high (median 9), as was comprehension (median 9), with no differences between patients with regard to disease stage (pre-ESRD vs. RRT) or educational level. Prior knowledge of the therapy was affected by the educational level (p=0.013 for the advantages and p=0.004 for the side effects) and the professional role (patients vs caregivers: p=0.009 for the advantages and p<0.001 for side affects); patient knowledge of the advantages (median 6) tended to increase as the disease progressed (p=0.015). The most common response by patients was that informed consent was necessary for all drugs (35.1%); 73.1% of the caregivers considered it necessary only for severe side effects. The preferred modality of consent was discussion with the caregiver during the clinical controls (42% of all cases)., Conclusions: Patient interest in and comprehension of an informed consent form with a detailed explanation of the therapy was high; the caregiver's opinion was still the most valued teaching tool.
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- 2005
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8. EPO or not-EPO? An evidence based informed consent.
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Mezza E, Piccoli GB, Pacitti A, Soragna G, Bermond F, Burdese M, Gai M, Motta D, Jeantet A, Merletti F, Vineis P, and Segoloni GP
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- Aged, Education, Medical, Undergraduate, Female, Humans, Italy, Male, Middle Aged, Nephrology education, Recombinant Proteins, Renal Dialysis adverse effects, Renal Dialysis methods, Risk Assessment, Schools, Medical, Erythropoietin administration & dosage, Evidence-Based Medicine, Informed Consent standards
- Abstract
Background: Informed consent is crucial in therapeutic choices; however, the forms presented to patients are often locally developed and information may not be homogeneous., Objective: To prepare an evidence-based model for informed consent, applied in the case of erythropoietin therapy (EPO) as a teaching tool for medical students., Methods: Methodological tools of Evidence-Based Medicine (EBM) were developed within the EBM Course in the Medical School of Torino, Italy, as problem solving and patient information tools (5th year students work in small groups under the supervision of statisticians, epidemiologists and experts of internal medicine--nephrology in this case)., Results: Methodological and ethical problems were identified: in the pre-dialysis field, evidence from randomized clinical trials (RCT) is scant; how to use evidence gathered in dialysis? How to deal with implementation? How with the mass media? Do we need to discuss the drug choice with the patients? How to deal with rare and severe side effects?). The "evidence" was searched for on Medline/Embase, by using key-words and free terms. About 680 papers were retrieved and screened. Forms available on the Internet were retrieved and a general scheme was drawn: it included 5 areas: title, aim and targets (patients and family physicians); search strategies and updating; pros and cons of therapy; alternative options; open questions., Conclusions: EBM may offer valuable tools for systematically approaching patient information; the inclusion of this kind of exercise in the Medical School EBM courses may help enhance the awareness of future physicians of the correct communication with patients.
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- 2004
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9. Maintenance of residual renal function 10 years after the start of hemodialysis: the advantage of tailored schedules?
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Piccoli GB, Burdese M, Mezza E, Consiglio V, Mangiarotti G, Thea A, Bermond F, Gai M, Lanfranco G, Jeantet A, and Segoloni GP
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- Humans, Kidney physiopathology, Kidney Failure, Chronic therapy, Male, Middle Aged, Time Factors, Appointments and Schedules, Creatinine metabolism, Kidney metabolism, Renal Dialysis methods
- Abstract
Maintenance of residual renal clearance is a clinical advantage, protecting against the long-term effects of uremia: although demonstrated in peritoneal dialysis, the strategies in hemodialysis are less clear. This case suggests that dialysis schedules individualized on the basis of renal clearances may help preserve residual function. SB is a 58 year-old male who started dialysis in emergency (creatinine 30.7 mg/dL) in 1993. He had a history of gout, small shrunken kidneys and moderate hypertension. The clinical diagnosis was vasculointerstitial nephropathy. Eighteen months after starting hemodialysis on a conventional thrice weekly schedule, the patient was switched to 2 sessions/week (creatinine clearance increased to 6 ml/min). Thereafter, clearances were checked in alternate months and treatment was tailored to an equivalent renal clearance > or =12 ml/min (1-2 sessions, 2-3.30 hours/week). Ten years after beginning dialysis, he is on a twice weekly schedule (3.30 hours), is normotensive, works full-time and does not want to go on a transplant waiting list.
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- 2004
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10. Twenty years of renal replacement therapy in a type 1 diabetic patient: advantages of a multiple choice dialysis system.
- Author
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Piccoli GB, Mesiano P, Mezza E, Pacitti A, Burdese M, Bermond F, Jeantet A, and Segoloni GP
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- Catheters, Indwelling, Creatinine blood, Female, Humans, Middle Aged, Treatment Outcome, Diabetes Mellitus, Type 1 complications, Diabetic Nephropathies therapy, Kidney Transplantation, Renal Dialysis
- Abstract
The prognosis of diabetic patients on renal replacement therapy (RRT) is usually poor. We report on the type 1 diabetic woman with the longest RRT follow-up in our area: over 20 years, half on dialysis, half with a renal graft. CS started RRT at age 27 on peritoneal dialysis (3 years), continued until an underdialysis syndrome developed, was switched to acetate dialysis and, because of poor tolerance, to hemofiltration which with good clinical results, allowing her to become the first Italian patient on home hemofiltration, which continued for 5 years. A cadaver graft lasted for the subsequent decade, despite several complications; afterwards she resumed bicarbonate dialysis, choosing a frequent home hemodialysis schedule. Despite several vascular access problems, her clinical conditions were good enough to candidate her for a second renal transplant, performed 3 years ago. This history of active self-care may draw attention to the advantages of a multiple choice dialysis network.
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- 2003
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11. Internet and the nephrologist: a new era?
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Piccoli GB, Burdese M, Mezza E, Quaglia M, Bermond F, Gai M, Soragna G, Bergamo D, Jeantet A, and Segoloni GP
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- Adult, Aged, Data Collection, Female, Humans, Information Services statistics & numerical data, Male, Middle Aged, Nephrology, PubMed, Surveys and Questionnaires, Databases as Topic statistics & numerical data, Internet statistics & numerical data
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- 2002
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12. Patient knowledge and interest on dialysis efficiency: a survey.
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Piccoli GB, Mezza E, Pacitti A, Iacuzzo C, Bechis F, Quaglia M, Anania P, Garofletti Y, Martino B, Peirano G, Aglì I, Jeantet A, and Segoloni GP
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- Adult, Aged, Books, Cartoons as Topic, Data Collection, Female, Humans, Male, Middle Aged, Self Care, Surveys and Questionnaires, Health Knowledge, Attitudes, Practice, Kidney Failure, Chronic therapy, Patient Education as Topic methods, Renal Dialysis
- Abstract
Background: Therapeutic compliance is fundamental on dialysis; however following a therapy requires a prior understanding of it. Aim of the study was to assess the need and interest for information on dialysis efficiency and to prepare a dedicated teaching tool., Methods: 72 patients, on hemodialysis in two limited-care satellite units, were given a questionnaire testing knowledge and interest on dialysis efficiency. In a subsequent second phase, following patients' suggestions, a cartoon book was prepared and opinions recorded., Results: 63 patients' returned the questionnaire. 79.4% had basic knowledge on routine blood tests, 30.1% were aware of their specific meaning. All patients asked for further information, preferring books to other media. The book "Kt/V as cartoon" was distributed; 71.2% read it, 93% scored it as good-very good. In the Unit employing flexible dialysis schedules, 22/42 patients increased dialysis time., Conclusions: Despite insufficient knowledge on dialysis efficiency, patient interest is high. An educational program is feasible and may also give practical results, such as self-increase in dialysis time.
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- 2002
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13. Daily dialysis Kt/V and flexible schedules: is it possible to control efficiency, when and how?
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Piccoli GB, Calderini M, Bechis F, Pacitti A, Vischi M, Iacuzzo C, Mezza E, Gai M, Anania P, Iadarola AM, Buniva C, Jeantet A, and Segoloni G
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- Adult, Analysis of Variance, Female, Hemodialysis, Home standards, Humans, Kidney Failure, Chronic therapy, Male, Middle Aged, Patient Compliance, Renal Dialysis standards, Urea metabolism
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Background: Daily hemodialysis is a promising treatment schedule but uniform criteria for defining efficiency are lacking., Methods: On our daily dialysis (DD) schedule, duration is flexible (2-3 hours, patients are free to add up to 30 min/session), Qb 250-350 mL/min; dialyser 1.6-1.8 m2. Study was performed on 12 pts on DD for > or = 2 months, with > or = 4 Kt/V on subsequent days, tested in the same laboratory., Goal: To evaluate variability and identify a simple method for weekly calculation, Kt/V was assessed for 133 sessions., Results: On flexible DD, variability of Kt/V-session is high (relative error 4.9%-22%). On flexible schedules, within the time range chosen (2-3 hours) variability of average hourly Kt/V is lower (standard deviation: min (0.014; max (0.052 hour, relative error 4.9%-10%) allowing calculation of weekly Kt/V (averaging 3 sessions: relative error < 6%) suitable for clinical practice., Conclusions: Flexible schedules, allowing patients to increase treatment time, are an interesting clinical option, but a challenge for Kt/V assessment.
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- 2001
14. Plasma exchange in progressive primary IgA nephropathy.
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Coppo R, Basolo B, Roccatello D, Giachino O, Lajolo D, Martina G, Rollino C, Amore A, Costa M, and Piccoli G
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- Adolescent, Adult, Child, Female, Humans, Immunoglobulin A analysis, Kidney Diseases immunology, Male, Middle Aged, Autoimmune Diseases therapy, Kidney Diseases therapy, Plasma Exchange
- Abstract
Five patients with progressive primary IgA nephropathy (PIgAGN) were treated by plasma-exchange (PE) combined with immunosuppressive drugs. Circulating IgA-containing immune complexes (IgAIC), detected by a specific conglutinin solid phase assay, were monitored. Two patients with acute nephritic syndrome and rapidly progressing course, crescent formations and high levels of IgAIC had substantial lasting clinical improvement after several PE, with a fall in IgAIC levels. Another rapidly progressive case with marked sclerotic changes and a longer history of nephritic syndrome, but with normal levels of IgAIC, did not show any clinical improvement after PE. Two patients with a PIgAGN diagnosed several years before and presenting slowly evolutive course had no substantial clinical benefit from PE treatment. IgAIC levels, very high before PE temporarily decreased, but returned to the previous values after the end of the treatment. We conclude that PE combined with immunosuppressive treatment may be of clinical benefit for cases with acute nephritic syndrome of recent onset who still have high levels of IgAIC, even when important crescent formations are present.
- Published
- 1985
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