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Purpose: Relapse in mental illness is an issue of concern to both the patients and caregivers. This study primarily focused on determining the rate of relapse and identifying the socio-demographic and clinical factors associated with relapse. Method: A 5 year retrospective study was done involving 219 clients admitted into a mental health care facility in Nigeria. A proforma was designed to collect data on the socio-demographic and clinical variables from the client’s case notes after obtaining ethical clearance. Data was fed into SPSS version 16 and analysed using univariate and bivariate statistic. Findings: Multiple logistic regression was performed to ascertain the effect of age at onset of illness, living arrangement, family background, social class, index employment status, educational status, duration of illness and drug compliance on the likelihood of relapse in mental illness. The model was statistically significant, X2 (24) = 69.52, p